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The map label for this gene is hflC [H]

Identifier: 238892659

GI number: 238892659

Start: 449143

End: 450147

Strand: Direct

Name: hflC [H]

Synonym: KP1_0444

Alternate gene names: 238892659

Gene position: 449143-450147 (Clockwise)

Preceding gene: 238892658

Following gene: 238892661

Centisome position: 8.56

GC content: 55.42

Gene sequence:

>1005_bases
ATGCGTAAATCTGTTATCGCGATCATTGTCATCGTGCTGGTAGTGCTCTACATGTCTGTCTTTGTCGTAAAGGAAGGCGA
GCGCGGTATCACGCTGCGTTTCGGTAAAGTTCTGCGCGACGACGAAAACAAGCCGCTGGTGTATGCGCCAGGCCTGCACT
TCAAGATCCCGTTTATCGAATCGGTGAAGATGCTGGATGCGCGTATTCAGACCATGGACAACCAGGCTGACCGTTTCGTT
ACTAAAGAGAAGAAAGACCTGATCGTCGACTCCTATATCAAGTGGCGCATCAGCGACTTCAGCCGTTACTACCTGGCAAC
CGGCGGCGGCGACGTCTCCCAGGCCGAGGTACTGCTGAAGCGTAAATTCTCTGACCGTCTGCGTTCTGAAATTGGTCGTC
TGGATGTGAAAGATATCGTCACCGACTCCCGTGGTCGCCTGACCCTGGAAGTGCGCGATGCGCTGAACTCGGGTTCGGCC
GGTACGGAAGATGAGGTTAGCACCCCGGCGGCTGACGACGCGATTGCTAAAGCGGCAGAGCGTGTGGAAGCCGAAACCAA
CGGTAAAGTGCAGGTGATCAACCCGAACAGTATGGCGGCGCTGGGTATCGAAGTTGTCGACGTACGTATCAAACAGATCA
ACCTGCCGGCAGAAGTGTCGGAAGCGATTTATAACCGTATGCGCGCGGAGCGTGAAGCGGTTGCTCGTCGCCATCGTTCA
CAGGGTCAGGAAGAGGCGGAAAAACTGCGCGCGACTGCGGACTATGAAGTCACCAAGACGCTGGCGGAAGCCGAGCGCCA
GGGCCGTATCCTGCGTGGTGAAGGTGATGCGGAATCAGCGAAACTGTTTGCCGACGCGTTCAGCCAGGATCCAGGCTTCT
ACTCCTTTATCCGTAGCCTGCGTGCCTATGAGAAGAGCTTCCAGAGCAATCAGGATGTGATGGTCCTGAGTCCGGACAGC
GATTTCTTCCGCTATATGCGTTCACCGGATTCGGCGCGTAAATAA

Upstream 100 bases:

>100_bases
CCAGCACCTCATCAACCTCGAGCTCAACCGGGGGTAGCATTATGGACCAACGCCGCGCTAACGCGCAGCGTAACGACTAC
CAGCGTCAGGGGGAATAACG

Downstream 100 bases:

>100_bases
GCCGGAGAAGGTGTAAACCTGAAGTAATAATGCGAAAAGGCGCCTGAAACAGGCGCCTTTTTTCATGCTGCGAGGGCGGG
AATTAGTTGCCGAGTAGCTT

Product: FtsH protease regulator HflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRKSVIAIIVIVLVVLYMSVFVVKEGERGITLRFGKVLRDDENKPLVYAPGLHFKIPFIESVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVSTPAADDAIAKAAERVEAETNGKVQVINPNSMAALGIEVVDVRIKQINLPAEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTKTLAEAERQGRILRGEGDAESAKLFADAFSQDPGFYSFIRSLRAYEKSFQSNQDVMVLSPDS
DFFRYMRSPDSARK

Sequences:

>Translated_334_residues
MRKSVIAIIVIVLVVLYMSVFVVKEGERGITLRFGKVLRDDENKPLVYAPGLHFKIPFIESVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVSTPAADDAIAKAAERVEAETNGKVQVINPNSMAALGIEVVDVRIKQINLPAEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTKTLAEAERQGRILRGEGDAESAKLFADAFSQDPGFYSFIRSLRAYEKSFQSNQDVMVLSPDS
DFFRYMRSPDSARK
>Mature_334_residues
MRKSVIAIIVIVLVVLYMSVFVVKEGERGITLRFGKVLRDDENKPLVYAPGLHFKIPFIESVKMLDARIQTMDNQADRFV
TKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSA
GTEDEVSTPAADDAIAKAAERVEAETNGKVQVINPNSMAALGIEVVDVRIKQINLPAEVSEAIYNRMRAEREAVARRHRS
QGQEEAEKLRATADYEVTKTLAEAERQGRILRGEGDAESAKLFADAFSQDPGFYSFIRSLRAYEKSFQSNQDVMVLSPDS
DFFRYMRSPDSARK

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=332, Percent_Identity=92.4698795180723, Blast_Score=586, Evalue=1e-169,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 37615; Mature: 37615

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSVIAIIVIVLVVLYMSVFVVKEGERGITLRFGKVLRDDENKPLVYAPGLHFKIPFIE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHCCCCCCCEEECCCCEEECCHHH
SVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVSTPAADDAIAKAAE
HHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RVEAETNGKVQVINPNSMAALGIEVVDVRIKQINLPAEVSEAIYNRMRAEREAVARRHRS
HHHHCCCCEEEEECCCCCHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTKTLAEAERQGRILRGEGDAESAKLFADAFSQDPGFYSFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
RAYEKSFQSNQDVMVLSPDSDFFRYMRSPDSARK
HHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRKSVIAIIVIVLVVLYMSVFVVKEGERGITLRFGKVLRDDENKPLVYAPGLHFKIPFIE
CCHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECHHHCCCCCCCEEECCCCEEECCHHH
SVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHH
RKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVSTPAADDAIAKAAE
HHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
RVEAETNGKVQVINPNSMAALGIEVVDVRIKQINLPAEVSEAIYNRMRAEREAVARRHRS
HHHHCCCCEEEEECCCCCHHHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
QGQEEAEKLRATADYEVTKTLAEAERQGRILRGEGDAESAKLFADAFSQDPGFYSFIRSL
CCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCHHHHHHHH
RAYEKSFQSNQDVMVLSPDSDFFRYMRSPDSARK
HHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]