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The map label for this gene is pepE [H]

Identifier: 238892492

GI number: 238892492

Start: 276090

End: 276779

Strand: Reverse

Name: pepE [H]

Synonym: KP1_0259

Alternate gene names: 238892492

Gene position: 276779-276090 (Counterclockwise)

Preceding gene: 238892494

Following gene: 238892489

Centisome position: 5.27

GC content: 60.58

Gene sequence:

>690_bases
ATGGAACTACTGTTACTCAGTAACTCCACGCTGCCGGGGAAAGCCTGGCTGGAACACGCCCTGCCGCTGATCGCCGGTCA
GGTCAAAGGCCGCCGTAAGGCGGTATTCATCCCCTTCGCTGGCGTGACGCAATCCTGGGATGATTATACGGCCAAAGTGG
CTGCGGTTATGGCGCCCATGGCGGTCAGCGTAACCGGTATCCACAGCGTCGACGACCCTATCGCCGCCATTGAAAGCACC
GAGATGGTGATCGTCGGCGGCGGGAACACCTTCCAGCTGTTGAAAGAGTGCCGCAGCCGCGGTCTGTTGGCGCCGATTGT
CGATGTCGTCAAACGCGGGGCGCTGTATATCGGCTGGAGCGCAGGTTCAAACCTTGCCTGCCCGACCATTCGCACCACCA
ACGATATGCCGATTGTCGATCCGCAGGGATTTGATGCGCTGGGGCTGTTCCCGCTACAGATTAACCCGCACTTCACCAAC
GCGTTGCCGACCGGGCATCAGGGCGAAACCCGCGAACAGCGTATCCGCGAACTACTGGTCGTGGCGCCGGAATTAACGGT
GATTGGTTTGCCGGAAGGAAACTGGATCCAGGTCACCGATGGTCACGCGACGCTCGGTGGCCCGAACCCGACGCTGTTGT
TCAAAGCGGGGGAAGAAGCGATAACCCTGCCTGCGGGCCACCGCTTCTGA

Upstream 100 bases:

>100_bases
AGCATTCCGCTTACCCACATCATGCGCCATATCAGCGCGTCGGTATGGGGGCGATGCTAGAATTTCTGCTTCAATAATAT
TTTTAAAACAGGAAGAAAAG

Downstream 100 bases:

>100_bases
GCCTGGTTGGCTAACGTTTCCCGGATAGCGGCGCATTGCGCCTTATCCGGGCTGCCTCAATGGAACGTCCAAACGCAAAA
TCCCGGTTAGCACAGCGCCG

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MELLLLSNSTLPGKAWLEHALPLIAGQVKGRRKAVFIPFAGVTQSWDDYTAKVAAVMAPMAVSVTGIHSVDDPIAAIEST
EMVIVGGGNTFQLLKECRSRGLLAPIVDVVKRGALYIGWSAGSNLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTN
ALPTGHQGETREQRIRELLVVAPELTVIGLPEGNWIQVTDGHATLGGPNPTLLFKAGEEAITLPAGHRF

Sequences:

>Translated_229_residues
MELLLLSNSTLPGKAWLEHALPLIAGQVKGRRKAVFIPFAGVTQSWDDYTAKVAAVMAPMAVSVTGIHSVDDPIAAIEST
EMVIVGGGNTFQLLKECRSRGLLAPIVDVVKRGALYIGWSAGSNLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTN
ALPTGHQGETREQRIRELLVVAPELTVIGLPEGNWIQVTDGHATLGGPNPTLLFKAGEEAITLPAGHRF
>Mature_229_residues
MELLLLSNSTLPGKAWLEHALPLIAGQVKGRRKAVFIPFAGVTQSWDDYTAKVAAVMAPMAVSVTGIHSVDDPIAAIEST
EMVIVGGGNTFQLLKECRSRGLLAPIVDVVKRGALYIGWSAGSNLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTN
ALPTGHQGETREQRIRELLVVAPELTVIGLPEGNWIQVTDGHATLGGPNPTLLFKAGEEAITLPAGHRF

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=229, Percent_Identity=86.4628820960699, Blast_Score=413, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24641669, Length=208, Percent_Identity=39.4230769230769, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 24459; Mature: 24459

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLLLSNSTLPGKAWLEHALPLIAGQVKGRRKAVFIPFAGVTQSWDDYTAKVAAVMAPM
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC
AVSVTGIHSVDDPIAAIESTEMVIVGGGNTFQLLKECRSRGLLAPIVDVVKRGALYIGWS
EEEEEECCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEC
AGSNLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTNALPTGHQGETREQRIRELLV
CCCCCCCCEEECCCCCCEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHE
VAPELTVIGLPEGNWIQVTDGHATLGGPNPTLLFKAGEEAITLPAGHRF
ECCCEEEEECCCCCEEEEECCCEECCCCCCEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MELLLLSNSTLPGKAWLEHALPLIAGQVKGRRKAVFIPFAGVTQSWDDYTAKVAAVMAPM
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC
AVSVTGIHSVDDPIAAIESTEMVIVGGGNTFQLLKECRSRGLLAPIVDVVKRGALYIGWS
EEEEEECCCCCCCHHHCCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEC
AGSNLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTNALPTGHQGETREQRIRELLV
CCCCCCCCEEECCCCCCEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHE
VAPELTVIGLPEGNWIQVTDGHATLGGPNPTLLFKAGEEAITLPAGHRF
ECCCEEEEECCCCCEEEEECCCEECCCCCCEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA