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The map label for this gene is iclR [H]

Identifier: 238892489

GI number: 238892489

Start: 269508

End: 270434

Strand: Reverse

Name: iclR [H]

Synonym: KP1_0256

Alternate gene names: 238892489

Gene position: 270434-269508 (Counterclockwise)

Preceding gene: 238892492

Following gene: 238892485

Centisome position: 5.15

GC content: 59.76

Gene sequence:

>927_bases
ATGTTCAGCTTCACTCCTCCGATGAGTCCGGTTGTGATTGCATTATTGCCAAATAAAACGAAAATTATTTCCACGATACA
GAAAAAGGAGTTCGCGATGGCCACTACCCCCATTCCCGCGAAACGCGGCAGAAAACCCGCGGCTGCCACTGCCCAGCAGG
CTGGCGGTCAGGTTCAGTCGCTGACCCGCGGCCTGAAATTACTCGAATGGATTGCCGAGTCCCACAGCAGCGTCGCGCTG
ACCGAACTGGCGCAGCAGGCGGGTCTGCCCAACTCCACGACTCACCGTCTGCTGACCACCATGCAACAGCTGGGCTTCGT
CCGCCAGGTTGGCGAGCTGGGTCACTGGGCCGTCGGGGCGCATGCTTTCGTGGTCGGCAGCAGCTTTCTACAAAGCCGCA
ATCTGCTGGCCATTGTCCACCCGATCCTGCGCCAGCTGATGGAAGATTCCGGTGAAACGGTGAATCTGGCGGTGCTCGAC
CAGAGCGACCACCAGGCGATCATTATCGATCAGGTGCAGTGCACCCAGCTGATGCGGATGTCGGCGCCAATCGGCGGTAA
ACTGCCGATGCACGCTTCCGGCGCCGGGAAGGCGTTTCTCGCGCAACTGAGCGAAGAGCAGGTCACCAGTCTGCTGCATC
GTAAAGGGCTGCATGCCTATACGCATGCCACGCTGGTCTCCCCGCTGCATCTGAAGGAAGATTTAGCCCAGACCCGCAAG
CGGGGCTACTCTTTCGATGATGAGGAGCACGCGCTCGGCCTGCGCTGCGTCGCCGCCTGCATTTACGATGAACATCGCGA
ACCGTTCGCGGCAATCTCCATCTCAGGCCCCATCTCGCGTATGACCGATGATCGGGTGACTGAGCTGGGCGCGCTGGTGA
TCAAGGCGGCGAAGGAAGTGACGCTGGCGTATGGCGGGGTTAAATAA

Upstream 100 bases:

>100_bases
ACACTTGCTCCCGACAACGCTCGACTCAGGCCAAATAGCCAACAAACCATACTGGCATAAACCACCGGAGCGGAAAAGAC
AACAACGGGCAATATGAGAC

Downstream 100 bases:

>100_bases
AAAAATGCCCCAGAGGGGCATTTTAAGTAGGCCTGATAAGCGTAGCGCCATCAGGCAGATCGGCGCACCTTGCCGGATGG
CGGCGTAAACGCCTTATCCG

Product: transcriptional repressor IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MFSFTPPMSPVVIALLPNKTKIISTIQKKEFAMATTPIPAKRGRKPAAATAQQAGGQVQSLTRGLKLLEWIAESHSSVAL
TELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWAVGAHAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLD
QSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKEDLAQTRK
RGYSFDDEEHALGLRCVAACIYDEHREPFAAISISGPISRMTDDRVTELGALVIKAAKEVTLAYGGVK

Sequences:

>Translated_308_residues
MFSFTPPMSPVVIALLPNKTKIISTIQKKEFAMATTPIPAKRGRKPAAATAQQAGGQVQSLTRGLKLLEWIAESHSSVAL
TELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWAVGAHAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLD
QSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKEDLAQTRK
RGYSFDDEEHALGLRCVAACIYDEHREPFAAISISGPISRMTDDRVTELGALVIKAAKEVTLAYGGVK
>Mature_308_residues
MFSFTPPMSPVVIALLPNKTKIISTIQKKEFAMATTPIPAKRGRKPAAATAQQAGGQVQSLTRGLKLLEWIAESHSSVAL
TELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWAVGAHAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLD
QSDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKEDLAQTRK
RGYSFDDEEHALGLRCVAACIYDEHREPFAAISISGPISRMTDDRVTELGALVIKAAKEVTLAYGGVK

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=272, Percent_Identity=91.5441176470588, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI1786715, Length=265, Percent_Identity=42.2641509433962, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788131, Length=259, Percent_Identity=29.3436293436293, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786468, Length=231, Percent_Identity=32.4675324675325, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789999, Length=227, Percent_Identity=33.4801762114537, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790752, Length=249, Percent_Identity=25.7028112449799, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788581, Length=249, Percent_Identity=26.1044176706827, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 33335; Mature: 33335

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSFTPPMSPVVIALLPNKTKIISTIQKKEFAMATTPIPAKRGRKPAAATAQQAGGQVQS
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHCCHHHH
LTRGLKLLEWIAESHSSVALTELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWAVGA
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLDQSDHQAIIIDQVQCTQLMRM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECHHHHHHHHHH
SAPIGGKLPMHASGAGKAFLAQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKEDLAQTRK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHH
RGYSFDDEEHALGLRCVAACIYDEHREPFAAISISGPISRMTDDRVTELGALVIKAAKEV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TLAYGGVK
HHHCCCCC
>Mature Secondary Structure
MFSFTPPMSPVVIALLPNKTKIISTIQKKEFAMATTPIPAKRGRKPAAATAQQAGGQVQS
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHCCCCCCHHHHHHHCCHHHH
LTRGLKLLEWIAESHSSVALTELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWAVGA
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLDQSDHQAIIIDQVQCTQLMRM
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECHHHHHHHHHH
SAPIGGKLPMHASGAGKAFLAQLSEEQVTSLLHRKGLHAYTHATLVSPLHLKEDLAQTRK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHH
RGYSFDDEEHALGLRCVAACIYDEHREPFAAISISGPISRMTDDRVTELGALVIKAAKEV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
TLAYGGVK
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]