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The map label for this gene is norM [H]

Identifier: 238027048

GI number: 238027048

Start: 1570319

End: 1571674

Strand: Reverse

Name: norM [H]

Synonym: bglu_1g14270

Alternate gene names: 238027048

Gene position: 1571674-1570319 (Counterclockwise)

Preceding gene: 238027049

Following gene: 238027047

Centisome position: 40.23

GC content: 70.43

Gene sequence:

>1356_bases
ATGCTCGCCGACGTCCGCCGCATCGCCGGCCTCGCCTGGCCGGTGCTGGTCGGCCAGCTCGCCATCATCGCGTTCGGCGT
GATCGACACCGCGATGGTGGGACGCTACTCGGCGCTCGATCTGGCCGCGCTCGGGCTCGGCTCGTCGATCTACGTGTCGG
TGTTCATCGGGCTGACCGGCATCCTCTCGGCGCTGCAGCCCATCGCGGGCCAGCTCTACGGCGCACGCCGCTTCCAGGAA
ATCGGCGAGGAAGTGCGCCAGGCGATGTGGTTGGCCCTGATGCTCGCCGTGCCGGGCTTCCTGCTGCTGCACTTCCCGGA
GCTGATACTGCGCGCCGCGCACGCGCCGCCGCAACTGCACGACCGCACCGTCGACTACCTGCGCATCCTCGCGTTCGGGC
TGCCCGCGAGCCTGATGTTCCGCATCTACAACGCGCTGACCAACGCCGCCGGCAAGCCGCGGCTCGCGATGATCCTGCAG
CTCGGCGCGCTCGCGCTGAAGATCCCGCTCAACGTCTGGTTCATCTTCGGCGGGCTCGGCGTGCCGGCGCTCGGCGGCCC
CGGCTGCGGGCTGGCCAGCACGCTGATCAACTGGGCACTCGCGCTGATCGGCTTCACGCTGGTTGCGCGGCTCGACGTGT
TCGCCCCGCTGGGCATCTTCGCGCGCTTTTGCACGCCAACCTGGGAACGCCAGAAGGCGCTGCTCAAGCTCGGGCTGCCG
ATGGGCCTGTCGTACCTGATCGAGGTCACGTCGTACACGTTCATGGCGCTGTTCATCTCGCACTTCGGCACCACCGTGCT
GGCCGGCCATCAGATCGCCGGCAACGTCGGCGCGGTGCTGTACATGACGCCGCTGTCGATCGGCATCGCGGCCTCGACGC
TGGTTGCGCGCGCGCTCGGCGCCGGCCGCCCCGACGAGGCGCGGCTGCTGGCGCGGCATGGCGTGAGCTTCGCGGCGCTC
ACCGCGCTCGGCTATGCCTGCGTGGTGCTTGCGCTGCGCCACTGGATCATCGGCGCCTACACGCCGAACCCGGCCGTGGT
CGCGGCCGCGCTGCCGCTCGTGACGATCGTCGCCTTCTACCACTGCGTGGATGCCGTCCAGGTCACCACCGCGTTCGTGC
TGCGCGCCTACAAGGTCGCGGTCGTGCCGACCGTGATCTACGCCGTCGCGCTGTGGGGCGTCGGCGTGGGCGGCGGCTAT
CTGCTCGGCTTCGACATCGGCGGCTGGGCGCCGGCCGCGTTCACCGGCGCACGCGGCTTCTGGTTCGCGAACTTCGCGAG
CCTGCTGATCGCGGGCGCGGCGCTCGTCGTCTATCTGAACCACATCAGCCGGCGCTGGCTGCACCGCGCGCCCTAG

Upstream 100 bases:

>100_bases
GCCGCGCGGCCGACCGCGACGAGCGCTTCCGCCTCTACGAGCGGATCGAGCGGCCCCGCTCGCCGCTACGACGCCATCCA
CGCGGCGCGCGCGGCTGACC

Downstream 100 bases:

>100_bases
GCCGAGCGCCCGCGCCCCGGCGCCTCAGCCGTCGAGGAACGCGTCGATCAGCCGGTTGACGTCGCCGGCCGCCGCGCCGG
GGGCGTCTCGCCGAGCGGGT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLADVRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRYSALDLAALGLGSSIYVSVFIGLTGILSALQPIAGQLYGARRFQE
IGEEVRQAMWLALMLAVPGFLLLHFPELILRAAHAPPQLHDRTVDYLRILAFGLPASLMFRIYNALTNAAGKPRLAMILQ
LGALALKIPLNVWFIFGGLGVPALGGPGCGLASTLINWALALIGFTLVARLDVFAPLGIFARFCTPTWERQKALLKLGLP
MGLSYLIEVTSYTFMALFISHFGTTVLAGHQIAGNVGAVLYMTPLSIGIAASTLVARALGAGRPDEARLLARHGVSFAAL
TALGYACVVLALRHWIIGAYTPNPAVVAAALPLVTIVAFYHCVDAVQVTTAFVLRAYKVAVVPTVIYAVALWGVGVGGGY
LLGFDIGGWAPAAFTGARGFWFANFASLLIAGAALVVYLNHISRRWLHRAP

Sequences:

>Translated_451_residues
MLADVRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRYSALDLAALGLGSSIYVSVFIGLTGILSALQPIAGQLYGARRFQE
IGEEVRQAMWLALMLAVPGFLLLHFPELILRAAHAPPQLHDRTVDYLRILAFGLPASLMFRIYNALTNAAGKPRLAMILQ
LGALALKIPLNVWFIFGGLGVPALGGPGCGLASTLINWALALIGFTLVARLDVFAPLGIFARFCTPTWERQKALLKLGLP
MGLSYLIEVTSYTFMALFISHFGTTVLAGHQIAGNVGAVLYMTPLSIGIAASTLVARALGAGRPDEARLLARHGVSFAAL
TALGYACVVLALRHWIIGAYTPNPAVVAAALPLVTIVAFYHCVDAVQVTTAFVLRAYKVAVVPTVIYAVALWGVGVGGGY
LLGFDIGGWAPAAFTGARGFWFANFASLLIAGAALVVYLNHISRRWLHRAP
>Mature_451_residues
MLADVRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRYSALDLAALGLGSSIYVSVFIGLTGILSALQPIAGQLYGARRFQE
IGEEVRQAMWLALMLAVPGFLLLHFPELILRAAHAPPQLHDRTVDYLRILAFGLPASLMFRIYNALTNAAGKPRLAMILQ
LGALALKIPLNVWFIFGGLGVPALGGPGCGLASTLINWALALIGFTLVARLDVFAPLGIFARFCTPTWERQKALLKLGLP
MGLSYLIEVTSYTFMALFISHFGTTVLAGHQIAGNVGAVLYMTPLSIGIAASTLVARALGAGRPDEARLLARHGVSFAAL
TALGYACVVLALRHWIIGAYTPNPAVVAAALPLVTIVAFYHCVDAVQVTTAFVLRAYKVAVVPTVIYAVALWGVGVGGGY
LLGFDIGGWAPAAFTGARGFWFANFASLLIAGAALVVYLNHISRRWLHRAP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=426, Percent_Identity=23.7089201877934, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994890, Length=451, Percent_Identity=33.2594235033259, Blast_Score=211, Evalue=9e-56,
Organism=Escherichia coli, GI226510954, Length=460, Percent_Identity=23.4782608695652, Blast_Score=89, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320545, Length=379, Percent_Identity=27.4406332453826, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321821, Length=345, Percent_Identity=22.6086956521739, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47896; Mature: 47896

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADVRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRYSALDLAALGLGSSIYVSVFIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
ILSALQPIAGQLYGARRFQEIGEEVRQAMWLALMLAVPGFLLLHFPELILRAAHAPPQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DRTVDYLRILAFGLPASLMFRIYNALTNAAGKPRLAMILQLGALALKIPLNVWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASTLINWALALIGFTLVARLDVFAPLGIFARFCTPTWERQKALLKLGLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
MGLSYLIEVTSYTFMALFISHFGTTVLAGHQIAGNVGAVLYMTPLSIGIAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRPDEARLLARHGVSFAALTALGYACVVLALRHWIIGAYTPNPAVVAAALPLVTIVAFY
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HCVDAVQVTTAFVLRAYKVAVVPTVIYAVALWGVGVGGGYLLGFDIGGWAPAAFTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCH
WFANFASLLIAGAALVVYLNHISRRWLHRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLADVRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRYSALDLAALGLGSSIYVSVFIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
ILSALQPIAGQLYGARRFQEIGEEVRQAMWLALMLAVPGFLLLHFPELILRAAHAPPQLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DRTVDYLRILAFGLPASLMFRIYNALTNAAGKPRLAMILQLGALALKIPLNVWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCC
VPALGGPGCGLASTLINWALALIGFTLVARLDVFAPLGIFARFCTPTWERQKALLKLGLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
MGLSYLIEVTSYTFMALFISHFGTTVLAGHQIAGNVGAVLYMTPLSIGIAASTLVARALG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEEEECHHHHHHHHHHHHHHHHC
AGRPDEARLLARHGVSFAALTALGYACVVLALRHWIIGAYTPNPAVVAAALPLVTIVAFY
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HCVDAVQVTTAFVLRAYKVAVVPTVIYAVALWGVGVGGGYLLGFDIGGWAPAAFTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCH
WFANFASLLIAGAALVVYLNHISRRWLHRAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA