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The map label for this gene is glxR [H]

Identifier: 238027012

GI number: 238027012

Start: 1531760

End: 1532659

Strand: Reverse

Name: glxR [H]

Synonym: bglu_1g13900

Alternate gene names: 238027012

Gene position: 1532659-1531760 (Counterclockwise)

Preceding gene: 238027013

Following gene: 238027010

Centisome position: 39.23

GC content: 69.78

Gene sequence:

>900_bases
ATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGCTCGCACATGGCGCGCAACCTGCTCAAGGGCGGCCACTCGCT
GGTCGTCAACGGCGCCTTCCCGGTGCCCGACGACCTGCGCGGGCAGGCCCGCGTGGTCGCGAACTCGACGGCGGTGGCCG
ACGGCGCCGAGATCCTCATCTCGATGGTGCCGGACACGCCCGACGTACACCGCGTGCTGTTCGCCGACGACGGGCTCGCG
AAGGGCCTGACGGCCGGCAAGCTGGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCAGGCATTCGCCAAGCGGAT
CAACGCGCTCGGCTGCGACTACCTCGACGCGCCGGTGTCGGGCGGCGAGGTCGGCGCGCGCGACGCGACGCTGACGATTA
TGGTGGGGGGCCCCGAGCGCGCGTTCGAGCGCGCCCGCCCGCTGTTCGAGCTGATGGGCAAGAACATCTCGCTGGTCGGC
GACAACGGCGCCGGCCAGACCACCAAGGTGGCCAACCAGATCATCGTCGCGCTGAACCTGGAAGCGGTGGCCGAGGCGCT
GCTGTTCGCGGCCCGCTCGGGCGCCGATCCGGAGCGCGTGCGGCGCGCGCTGATGGGCGGCTTCGCGTCGTCGCGCATCC
TCGAGCTGCACGGCGAACGGATGACCAAGCGCACCTTCGAGCCGGGCTTTCGCATCGAGCTGCACCAGAAGGACCTGAAC
CTCGCGCTCGACGGCGCACGCCGCCTCGGCCTCGCGCTACCGCATACCGCCAGCGCGCAGCAGCTGTTCAGCGTGTGCGC
CGCGCACGGCGGCAAGACCTGGGATCACTCGGGTATCGTCCGCGCACTCGAAATCATGTCCAACCTCGAGATCGCCGAGC
CCACGGCAACCGCGAAGTAG

Upstream 100 bases:

>100_bases
CACCACCACCCGCGACGGGCTCGGCTGGCTGCGCGAGGCGAGGCAGTGCAGCGCCGCACACGCCTGACGCCCCTTTCTTA
CCCTCGCTACGGAGCACAAC

Downstream 100 bases:

>100_bases
ACATCGGCCCGGCACGCCGCCCCGGCTGGCGGCGCGCCGCACGGTGGGGCGTCCGTCGGATCTTCGGCTCCGGCGGGCGG
TTGAAGGCCGCTCTGGGCTG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MATIGFIGLGIMGSHMARNLLKGGHSLVVNGAFPVPDDLRGQARVVANSTAVADGAEILISMVPDTPDVHRVLFADDGLA
KGLTAGKLVIDMSSISPLDTQAFAKRINALGCDYLDAPVSGGEVGARDATLTIMVGGPERAFERARPLFELMGKNISLVG
DNGAGQTTKVANQIIVALNLEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFEPGFRIELHQKDLN
LALDGARRLGLALPHTASAQQLFSVCAAHGGKTWDHSGIVRALEIMSNLEIAEPTATAK

Sequences:

>Translated_299_residues
MATIGFIGLGIMGSHMARNLLKGGHSLVVNGAFPVPDDLRGQARVVANSTAVADGAEILISMVPDTPDVHRVLFADDGLA
KGLTAGKLVIDMSSISPLDTQAFAKRINALGCDYLDAPVSGGEVGARDATLTIMVGGPERAFERARPLFELMGKNISLVG
DNGAGQTTKVANQIIVALNLEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFEPGFRIELHQKDLN
LALDGARRLGLALPHTASAQQLFSVCAAHGGKTWDHSGIVRALEIMSNLEIAEPTATAK
>Mature_298_residues
ATIGFIGLGIMGSHMARNLLKGGHSLVVNGAFPVPDDLRGQARVVANSTAVADGAEILISMVPDTPDVHRVLFADDGLAK
GLTAGKLVIDMSSISPLDTQAFAKRINALGCDYLDAPVSGGEVGARDATLTIMVGGPERAFERARPLFELMGKNISLVGD
NGAGQTTKVANQIIVALNLEAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFEPGFRIELHQKDLNL
ALDGARRLGLALPHTASAQQLFSVCAAHGGKTWDHSGIVRALEIMSNLEIAEPTATAK

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=31.9587628865979, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=27.6595744680851, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1786719, Length=290, Percent_Identity=62.7586206896552, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=41.3793103448276, Blast_Score=230, Evalue=9e-62,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=34.4827586206897, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=28.5211267605634, Blast_Score=100, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=32.9861111111111, Blast_Score=127, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24655230, Length=274, Percent_Identity=33.9416058394161, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19922568, Length=274, Percent_Identity=33.9416058394161, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574115, Length=284, Percent_Identity=26.7605633802817, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31508; Mature: 31377

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGSHMARNLLKGGHSLVVNGAFPVPDDLRGQARVVANSTAVADGAEILI
CCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHEEE
SMVPDTPDVHRVLFADDGLAKGLTAGKLVIDMSSISPLDTQAFAKRINALGCDYLDAPVS
EECCCCCCCEEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPERAFERARPLFELMGKNISLVGDNGAGQTTKVANQIIVALNL
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEEEEECH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFEPGFRIELHQKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
LALDGARRLGLALPHTASAQQLFSVCAAHGGKTWDHSGIVRALEIMSNLEIAEPTATAK
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATIGFIGLGIMGSHMARNLLKGGHSLVVNGAFPVPDDLRGQARVVANSTAVADGAEILI
CEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHEEE
SMVPDTPDVHRVLFADDGLAKGLTAGKLVIDMSSISPLDTQAFAKRINALGCDYLDAPVS
EECCCCCCCEEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDATLTIMVGGPERAFERARPLFELMGKNISLVGDNGAGQTTKVANQIIVALNL
CCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHEEEEECH
EAVAEALLFAARSGADPERVRRALMGGFASSRILELHGERMTKRTFEPGFRIELHQKDLN
HHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
LALDGARRLGLALPHTASAQQLFSVCAAHGGKTWDHSGIVRALEIMSNLEIAEPTATAK
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]