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The map label for this gene is hyi [H]

Identifier: 238027013

GI number: 238027013

Start: 1532693

End: 1533490

Strand: Reverse

Name: hyi [H]

Synonym: bglu_1g13910

Alternate gene names: 238027013

Gene position: 1533490-1532693 (Counterclockwise)

Preceding gene: 238027014

Following gene: 238027012

Centisome position: 39.25

GC content: 69.67

Gene sequence:

>798_bases
ATGCCGAAATTCGCCGCCAACCTGACGATGCTGTTCAACGAAGTGCCGTTCCTCGAGCGGTTCGAGGCCGCCGCCGAGGC
GGGCTTCGACGCCGTCGAGTTCCTGTTTCCGTACTCCTATGCGAAGGAGCAACTGGCCGAGCGGCTCGCCGCCCACCGCC
TGAAGCTGGTGCTGCACAACCTGCCCGCCGGCAACTGGGACCAGGGCGAGCGCGGCATCGCCTGCCTGCCGGACCGGCGC
GGCGAGTTTCAGGACGGCGTGGGCCGCGCGATCGACTATGCGAAGGCGCTCGGCGTGCCGCAGCTGAACTGCCTGGTCGG
CATCGCGTCGGCCAGCGTGCCGCGCGACACCACCCACCTGACGATCGTCGAGAACCTGCGCTTCGCCGCCGACGCCCTCG
AGCGCGAGGGCATCCGGCTGCTGGTGGAGCCGTGCAACCACTTCGACCTTCCCGGCTTCGCGCTGAACCGCTCGACCGAG
GCGCTCGACGTGATCCGCGCGGTCGGCTCCGACAACCTGTTCCTGCAATACGACATCTATCACATGCAGCGCATGGAGGG
CGAGCTCGCGGCGACGCTGCGCGCGAACCTGCCGGCGATCGGCCATGTCCAGCTGGCCGACAACCCGGGCCGCCACGAGC
CCGGCACCGGCGAGATCCGCTACGCCTACCTGTTCGGCCTGCTCGACGAGCTCGGCTACCACGGCCATGTCGGCTGCGAG
TACAAGCCACGCACCACCACCCGCGACGGGCTCGGCTGGCTGCGCGAGGCGAGGCAGTGCAGCGCCGCACACGCCTGA

Upstream 100 bases:

>100_bases
AACGAGTTCGAGCCGCTCGCCGAGCGCCCCGAACACGCGCCGACCGCGATCTCGCTGCTCGACTGAGCCTGCTGCTTGCC
GACCGACCGGAGACCCCGCC

Downstream 100 bases:

>100_bases
CGCCCCTTTCTTACCCTCGCTACGGAGCACAACATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGCTCGCACAT
GGCGCGCAACCTGCTCAAGG

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPKFAANLTMLFNEVPFLERFEAAAEAGFDAVEFLFPYSYAKEQLAERLAAHRLKLVLHNLPAGNWDQGERGIACLPDRR
GEFQDGVGRAIDYAKALGVPQLNCLVGIASASVPRDTTHLTIVENLRFAADALEREGIRLLVEPCNHFDLPGFALNRSTE
ALDVIRAVGSDNLFLQYDIYHMQRMEGELAATLRANLPAIGHVQLADNPGRHEPGTGEIRYAYLFGLLDELGYHGHVGCE
YKPRTTTRDGLGWLREARQCSAAHA

Sequences:

>Translated_265_residues
MPKFAANLTMLFNEVPFLERFEAAAEAGFDAVEFLFPYSYAKEQLAERLAAHRLKLVLHNLPAGNWDQGERGIACLPDRR
GEFQDGVGRAIDYAKALGVPQLNCLVGIASASVPRDTTHLTIVENLRFAADALEREGIRLLVEPCNHFDLPGFALNRSTE
ALDVIRAVGSDNLFLQYDIYHMQRMEGELAATLRANLPAIGHVQLADNPGRHEPGTGEIRYAYLFGLLDELGYHGHVGCE
YKPRTTTRDGLGWLREARQCSAAHA
>Mature_264_residues
PKFAANLTMLFNEVPFLERFEAAAEAGFDAVEFLFPYSYAKEQLAERLAAHRLKLVLHNLPAGNWDQGERGIACLPDRRG
EFQDGVGRAIDYAKALGVPQLNCLVGIASASVPRDTTHLTIVENLRFAADALEREGIRLLVEPCNHFDLPGFALNRSTEA
LDVIRAVGSDNLFLQYDIYHMQRMEGELAATLRANLPAIGHVQLADNPGRHEPGTGEIRYAYLFGLLDELGYHGHVGCEY
KPRTTTRDGLGWLREARQCSAAHA

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=264, Percent_Identity=41.6666666666667, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI300068964, Length=247, Percent_Identity=40.080971659919, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=56.9767441860465, Blast_Score=301, Evalue=3e-83,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=43.0232558139535, Blast_Score=225, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=39.5833333333333, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17530883, Length=258, Percent_Identity=34.4961240310078, Blast_Score=154, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 29388; Mature: 29256

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLFNEVPFLERFEAAAEAGFDAVEFLFPYSYAKEQLAERLAAHRLKLVLHN
CCCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LPAGNWDQGERGIACLPDRRGEFQDGVGRAIDYAKALGVPQLNCLVGIASASVPRDTTHL
CCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCEEE
TIVENLRFAADALEREGIRLLVEPCNHFDLPGFALNRSTEALDVIRAVGSDNLFLQYDIY
EHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATLRANLPAIGHVQLADNPGRHEPGTGEIRYAYLFGLLDELGYHGHVGCE
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
YKPRTTTRDGLGWLREARQCSAAHA
ECCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKFAANLTMLFNEVPFLERFEAAAEAGFDAVEFLFPYSYAKEQLAERLAAHRLKLVLHN
CCHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LPAGNWDQGERGIACLPDRRGEFQDGVGRAIDYAKALGVPQLNCLVGIASASVPRDTTHL
CCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHEEECCCCCCCCCEEE
TIVENLRFAADALEREGIRLLVEPCNHFDLPGFALNRSTEALDVIRAVGSDNLFLQYDIY
EHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEHHH
HMQRMEGELAATLRANLPAIGHVQLADNPGRHEPGTGEIRYAYLFGLLDELGYHGHVGCE
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
YKPRTTTRDGLGWLREARQCSAAHA
ECCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]