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The map label for this gene is aes [H]

Identifier: 238026997

GI number: 238026997

Start: 1517088

End: 1518047

Strand: Direct

Name: aes [H]

Synonym: bglu_1g13750

Alternate gene names: 238026997

Gene position: 1517088-1518047 (Clockwise)

Preceding gene: 238026996

Following gene: 238027000

Centisome position: 38.83

GC content: 73.12

Gene sequence:

>960_bases
ATGCCGCTCAATCCCGTCATTGCGCAGGTCCTCGAGATGATCGGGCGGGCCCGGCGCCCGTCCTTCGCGTCGCAGACGCC
GCAGGCCGCGCGCGCCGCCTACGAGCGCAGCGCGACGATCCTCGAGATCGCGCCCGCGCCGATGGCCGAGGTCGAAGACC
TGCGCGTGCCGATGCGCGACGGCACAACGATCGGCGCGCGGCTCTATCTGCCGGTCGCACCGAGCCTCGCCGAGCCGCTG
CCGACGCTGGTCTACTATCACGGCGGCGGCTTCATGATCGGCAGCCTCGACACGCACGACGCGCTGTGCCGGATGTTCGC
GCGCGACGCGCATTGCGCGGTGCTGGCGGTGGATTACCGGCTCGCGCCGGAGGCGACGTTCCCGACCGCCCACGACGACG
CGCAGGACGCGCTGCTCTGGCTGCATGCCCATGCGAGCGGGTTCGGCCTCGACGCGGCGCGCTTCGCGGTGGGCGGCGAC
AGCGCGGGCGGCACGCTCGCCGCGGCCGTGGCCGTGCTCGCGCGCGATCACGGCATCGCCCTCGCGCTGCAAATGCTGAT
CTACCCCGGCGTGAGCGCGCACCAGCAGACCGCCTCGCACGCGCGGCTCGGCGACGGCTACCTGCTGACGGCCGAGACGA
TTCAGTGGTTCTTCTCGCACTATGTGCGCGATCCGGCCGACCGCGAGGACTGGCGGTTCGCGCCGCTCGACGGCCGGCGC
GGCGCGCCGTCGTTCGCGGGCGTCGCGCCGGCCTGGATCGCCGTGGCCGAATACGATCCGCTCTCGGACGAGGGCGTCGC
CTACGCGGACAAGCTGCGCGCGGCCGGCAACGCCGTCACGCTGGTGCGCTACGCCGGCATGATCCACGAGTTCTTCAAGA
TGGGCGGCTACGTCCCCGAGGTCCGGCAGGCGCACGCCGACGCGGCCGGCGCGTTGCGCGAGGCGTTCGACGCGGTCTGA

Upstream 100 bases:

>100_bases
GCCGCCCCGGCCGCGGCTGCTATTTCGTGATGCCCGATCTGCACGGTGTCGCGCGAGCGATGGCATCATGGCCCGCTGTC
GCCACTCTTCCTGCCCATCC

Downstream 100 bases:

>100_bases
ACGGCGCGCCGCGCGCCGGCGCCGCCCGGCTAGCGCGCGCCGCCCAGCGCGACGTCGAAGTGCATCGCGCGCTCGAACGC
GCCGGGCCGCACGATCCGGT

Product: Esterase

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPLNPVIAQVLEMIGRARRPSFASQTPQAARAAYERSATILEIAPAPMAEVEDLRVPMRDGTTIGARLYLPVAPSLAEPL
PTLVYYHGGGFMIGSLDTHDALCRMFARDAHCAVLAVDYRLAPEATFPTAHDDAQDALLWLHAHASGFGLDAARFAVGGD
SAGGTLAAAVAVLARDHGIALALQMLIYPGVSAHQQTASHARLGDGYLLTAETIQWFFSHYVRDPADREDWRFAPLDGRR
GAPSFAGVAPAWIAVAEYDPLSDEGVAYADKLRAAGNAVTLVRYAGMIHEFFKMGGYVPEVRQAHADAAGALREAFDAV

Sequences:

>Translated_319_residues
MPLNPVIAQVLEMIGRARRPSFASQTPQAARAAYERSATILEIAPAPMAEVEDLRVPMRDGTTIGARLYLPVAPSLAEPL
PTLVYYHGGGFMIGSLDTHDALCRMFARDAHCAVLAVDYRLAPEATFPTAHDDAQDALLWLHAHASGFGLDAARFAVGGD
SAGGTLAAAVAVLARDHGIALALQMLIYPGVSAHQQTASHARLGDGYLLTAETIQWFFSHYVRDPADREDWRFAPLDGRR
GAPSFAGVAPAWIAVAEYDPLSDEGVAYADKLRAAGNAVTLVRYAGMIHEFFKMGGYVPEVRQAHADAAGALREAFDAV
>Mature_318_residues
PLNPVIAQVLEMIGRARRPSFASQTPQAARAAYERSATILEIAPAPMAEVEDLRVPMRDGTTIGARLYLPVAPSLAEPLP
TLVYYHGGGFMIGSLDTHDALCRMFARDAHCAVLAVDYRLAPEATFPTAHDDAQDALLWLHAHASGFGLDAARFAVGGDS
AGGTLAAAVAVLARDHGIALALQMLIYPGVSAHQQTASHARLGDGYLLTAETIQWFFSHYVRDPADREDWRFAPLDGRRG
APSFAGVAPAWIAVAEYDPLSDEGVAYADKLRAAGNAVTLVRYAGMIHEFFKMGGYVPEVRQAHADAAGALREAFDAV

Specific function: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI61966717, Length=257, Percent_Identity=27.2373540856031, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI68299767, Length=296, Percent_Identity=27.7027027027027, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI157041239, Length=159, Percent_Identity=36.4779874213836, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI206597554, Length=174, Percent_Identity=33.9080459770115, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI68051721, Length=281, Percent_Identity=27.4021352313167, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI21328446, Length=97, Percent_Identity=35.0515463917526, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786682, Length=318, Percent_Identity=29.874213836478, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71996133, Length=209, Percent_Identity=30.1435406698565, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540028, Length=147, Percent_Identity=34.0136054421769, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001146, Length=110, Percent_Identity=38.1818181818182, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24656084, Length=102, Percent_Identity=38.2352941176471, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656076, Length=102, Percent_Identity=38.2352941176471, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130169, Length=102, Percent_Identity=38.2352941176471, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 34150; Mature: 34019

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNPVIAQVLEMIGRARRPSFASQTPQAARAAYERSATILEIAPAPMAEVEDLRVPMRD
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCC
GTTIGARLYLPVAPSLAEPLPTLVYYHGGGFMIGSLDTHDALCRMFARDAHCAVLAVDYR
CCEECEEEEEECCCHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHCCCCEEEEEEEEE
LAPEATFPTAHDDAQDALLWLHAHASGFGLDAARFAVGGDSAGGTLAAAVAVLARDHGIA
ECCCCCCCCCCCCHHHHEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCCHH
LALQMLIYPGVSAHQQTASHARLGDGYLLTAETIQWFFSHYVRDPADREDWRFAPLDGRR
HHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
GAPSFAGVAPAWIAVAEYDPLSDEGVAYADKLRAAGNAVTLVRYAGMIHEFFKMGGYVPE
CCCCCCCCCHHHEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
VRQAHADAAGALREAFDAV
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLNPVIAQVLEMIGRARRPSFASQTPQAARAAYERSATILEIAPAPMAEVEDLRVPMRD
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCC
GTTIGARLYLPVAPSLAEPLPTLVYYHGGGFMIGSLDTHDALCRMFARDAHCAVLAVDYR
CCEECEEEEEECCCHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHCCCCEEEEEEEEE
LAPEATFPTAHDDAQDALLWLHAHASGFGLDAARFAVGGDSAGGTLAAAVAVLARDHGIA
ECCCCCCCCCCCCHHHHEEEEEECCCCCCCCHHHEEECCCCCCHHHHHHHHHHHCCCCHH
LALQMLIYPGVSAHQQTASHARLGDGYLLTAETIQWFFSHYVRDPADREDWRFAPLDGRR
HHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCEECCCCCCC
GAPSFAGVAPAWIAVAEYDPLSDEGVAYADKLRAAGNAVTLVRYAGMIHEFFKMGGYVPE
CCCCCCCCCHHHEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
VRQAHADAAGALREAFDAV
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA