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The map label for this gene is uppS [H]

Identifier: 238026906

GI number: 238026906

Start: 1398960

End: 1399742

Strand: Direct

Name: uppS [H]

Synonym: bglu_1g12760

Alternate gene names: 238026906

Gene position: 1398960-1399742 (Clockwise)

Preceding gene: 238026905

Following gene: 238026907

Centisome position: 35.81

GC content: 67.69

Gene sequence:

>783_bases
ATGACTCATACCAGCTCTACCGTTCGCGTGCCCGACGTTGCCGCCGTGCCACGTCACATCGCGATCATCATGGACGGCAA
CGGCAGGTGGGCGACCGAGCGTCGCCTGCCGCGCGTTGCGGGGCACACGCGCGGCGTCGATGCGGTCCGGTCGGTCGTGG
AAGGGTGCGCGCGCGCGGGCGTCGAATACCTGACGCTGTTCGCGTTCAGTTCCGAGAACTGGCGGCGGCCTACCGACGAG
GTCTCGTTCCTGATGCGGCTGTTCATCACCGCGCTCGAGCGCGAGGTCGGCAAGCTGCACGCGAACGGCATCCGGCTGCG
CGTGGTGGGCGATCTCGACCGCTTCGAGCCGCGCATCCGCGAGCTGATCCGGCGCGCGGAAACCAAGACCGCGCGCAACA
CGCGGCTCACGTTGACGATCGCCGCGAACTACGGCGGCCGCTGGGACATCCTGCAGGCCACCAGAAAGCTGATCGCCGAG
GCGGTGCGCGAGGGGCGCGAGATCCCGGTCGACGAAGCCGCGTTCGAGCCGCATCTCGCGATGGCCTATGCGCCCGAGCC
GGACCTGTTCATCCGCACCGGCGGCGAGCAGCGCGTGAGCAACTTCCTGCTCTGGCAACTCGCCTACACCGAGTTCTATT
TCACGGGCAAGTTCTGGCCCGATTTCGATGCGACCGCGCTCGCCGATGCGATGGCGTCCTACACCGACCGCGAGCGCCGC
TTCGGGCGGACCAGCGCGCAGCTCGAACCTCAATCGCAGGACGTCGATTCCCTTTCATGCTGA

Upstream 100 bases:

>100_bases
GACAAGCTGGTGCAGGCGAAGGACGCCGAGATCATGACGGTCTGACGCAGCTTTGCGCGCGTCCGTTGCACTTTTTCCCG
CAGTTACAGTCTCAGCGGCC

Downstream 100 bases:

>100_bases
AGACCCGCGTCATCACGGCGGTCGTGCTGCTGGCAGTGCTGCTGCCGGTCACGCTGTTCGCGCCGCTCGCGGCGTTCGGC
GCACTGATCGCGCTGGTGCT

Product: Di-trans-poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTHTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPTDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATRKLIAE
AVREGREIPVDEAAFEPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYTEFYFTGKFWPDFDATALADAMASYTDRERR
FGRTSAQLEPQSQDVDSLSC

Sequences:

>Translated_260_residues
MTHTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPTDE
VSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATRKLIAE
AVREGREIPVDEAAFEPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYTEFYFTGKFWPDFDATALADAMASYTDRERR
FGRTSAQLEPQSQDVDSLSC
>Mature_259_residues
THTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAGVEYLTLFAFSSENWRRPTDEV
SFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIRELIRRAETKTARNTRLTLTIAANYGGRWDILQATRKLIAEA
VREGREIPVDEAAFEPHLAMAYAPEPDLFIRTGGEQRVSNFLLWQLAYTEFYFTGKFWPDFDATALADAMASYTDRERRF
GRTSAQLEPQSQDVDSLSC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=34.375, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=34.375, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=54.585152838428, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=33.4801762114537, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=239, Percent_Identity=35.9832635983264, Blast_Score=128, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=33.7777777777778, Blast_Score=122, Evalue=8e-29,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=34.9282296650718, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29475; Mature: 29344

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAG
CCCCCCEEECCCHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPTDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIR
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATRKLIAEAVREGREIPVDEAAFEPHLA
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEE
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYTEFYFTGKFWPDFDATALADAMASYTDRERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQDVDSLSC
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THTSSTVRVPDVAAVPRHIAIIMDGNGRWATERRLPRVAGHTRGVDAVRSVVEGCARAG
CCCCCEEECCCHHHCCCEEEEEECCCCCCCHHHCCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPTDEVSFLMRLFITALEREVGKLHANGIRLRVVGDLDRFEPRIR
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCHHHH
ELIRRAETKTARNTRLTLTIAANYGGRWDILQATRKLIAEAVREGREIPVDEAAFEPHLA
HHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEE
MAYAPEPDLFIRTGGEQRVSNFLLWQLAYTEFYFTGKFWPDFDATALADAMASYTDRERR
EEECCCCCEEEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
FGRTSAQLEPQSQDVDSLSC
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]