Click here to switch to the map view.

The map label for this gene is ilvR [H]

Identifier: 238026741

GI number: 238026741

Start: 1207688

End: 1208593

Strand: Direct

Name: ilvR [H]

Synonym: bglu_1g10990

Alternate gene names: 238026741

Gene position: 1207688-1208593 (Clockwise)

Preceding gene: 238026739

Following gene: 238026742

Centisome position: 30.91

GC content: 74.5

Gene sequence:

>906_bases
ATGATCCGTGAACTGAAAACCTTTCTGTCGGTGGTGCGCCACGGCACCTTCGCGCGCGCCGGCGCGCAGGTCGGCCTCAC
GCAGTCGGCCGTCAGCGCGCAGATCCAGCGGCTCGAGGACGAACTCGGCTTCGCGCTGTTCGATCGCACCGGCCGCTCGG
CCAGGCTGAACGCGGCGGGACGGCGCACCGTCGAGCGTGCCGAGGAACTGCTGACCGCCTACGCGCGGCTCGCCGACCAG
GGCCCGGCCGCGGAGGACCGCGGCCTGCTGCGGATCGGCGCGATCGCCTCGGCGCAGACCGCGCTGCTGGTGCGCGCCAT
CGTGCCGTTTCGCGAGCGCGCGCCGGGCTGGCGCGTGCGCGTGATCCCGGGCGTGTCGCTGAACCTGCTCGCGCAGGTCG
ATTCGGGCGAGGTGGACGGCGCGGTGTTGATCCGCCCGCCGTTCGCGCTGCCGGCCGAGCTGACCTGGCGCGCGCTCGTG
CACGAGCCGTTCGTGCTGCTGGTGCCGCGCGCGCTGCGCCACGAGCAGGCCCGCGTGCTGCTCAGGCGCGAACCGTTCGT
GCGCTACGACCGCAACTCGTTCGGCGGGCGCATCGTCGATCGCTGGCTGCGCAAGGTCCGACTGAGCGTGCACGACGTGA
TCGAGCTCGACGAACTGCAGGCGATCGTCGAACTGGTGGGATGCGGCGTCGGGGTGGCGCTGGTGCCGCTCGCGAGCGCG
CTGCGCCTGCCGCGCACGGTGGCGGCCCTGCCGCTCGGCGACGAGCCGCCGATGCGCGAGATCGGCTATGTCGAGCGCGC
CGGCGCACGCCCCGATGCGGCCGCGGCGTTCGCCGAATGCCTGGCGGCGGCGGTGCGCGAGCCGGCCGCGGCGCCGCCAC
GCCGCGGTCGATCGGCGGCCTCGTAG

Upstream 100 bases:

>100_bases
CGAGGCAAGCGCGGCGACGCCGCCGGCTACCCATCAAGGAATGCGTTGAGAGGCGCGTAAGATTGGCCGCTTTCCAGCAG
AAATTTCGATCGATCGGCCC

Downstream 100 bases:

>100_bases
TGAATCGGTCCGGCCGCTCGTCGTTCGGCTGCCGGATCGCTCCGGCTCACCGCCGGGTGGCGGCACCGGCGGCGGGGTGG
GCGGCCGTGTCGACGCGGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIRELKTFLSVVRHGTFARAGAQVGLTQSAVSAQIQRLEDELGFALFDRTGRSARLNAAGRRTVERAEELLTAYARLADQ
GPAAEDRGLLRIGAIASAQTALLVRAIVPFRERAPGWRVRVIPGVSLNLLAQVDSGEVDGAVLIRPPFALPAELTWRALV
HEPFVLLVPRALRHEQARVLLRREPFVRYDRNSFGGRIVDRWLRKVRLSVHDVIELDELQAIVELVGCGVGVALVPLASA
LRLPRTVAALPLGDEPPMREIGYVERAGARPDAAAAFAECLAAAVREPAAAPPRRGRSAAS

Sequences:

>Translated_301_residues
MIRELKTFLSVVRHGTFARAGAQVGLTQSAVSAQIQRLEDELGFALFDRTGRSARLNAAGRRTVERAEELLTAYARLADQ
GPAAEDRGLLRIGAIASAQTALLVRAIVPFRERAPGWRVRVIPGVSLNLLAQVDSGEVDGAVLIRPPFALPAELTWRALV
HEPFVLLVPRALRHEQARVLLRREPFVRYDRNSFGGRIVDRWLRKVRLSVHDVIELDELQAIVELVGCGVGVALVPLASA
LRLPRTVAALPLGDEPPMREIGYVERAGARPDAAAAFAECLAAAVREPAAAPPRRGRSAAS
>Mature_301_residues
MIRELKTFLSVVRHGTFARAGAQVGLTQSAVSAQIQRLEDELGFALFDRTGRSARLNAAGRRTVERAEELLTAYARLADQ
GPAAEDRGLLRIGAIASAQTALLVRAIVPFRERAPGWRVRVIPGVSLNLLAQVDSGEVDGAVLIRPPFALPAELTWRALV
HEPFVLLVPRALRHEQARVLLRREPFVRYDRNSFGGRIVDRWLRKVRLSVHDVIELDELQAIVELVGCGVGVALVPLASA
LRLPRTVAALPLGDEPPMREIGYVERAGARPDAAAAFAECLAAAVREPAAAPPRRGRSAAS

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=26.1168384879725, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788887, Length=243, Percent_Identity=27.9835390946502, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788748, Length=250, Percent_Identity=27.6, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=29.4372294372294, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790208, Length=245, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786401, Length=169, Percent_Identity=33.1360946745562, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790399, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082132, Length=300, Percent_Identity=27, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789440, Length=94, Percent_Identity=36.1702127659575, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788481, Length=242, Percent_Identity=28.099173553719, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=172, Percent_Identity=27.3255813953488, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI48994962, Length=99, Percent_Identity=39.3939393939394, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787806, Length=282, Percent_Identity=21.9858156028369, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32704; Mature: 32704

Theoretical pI: Translated: 11.18; Mature: 11.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRELKTFLSVVRHGTFARAGAQVGLTQSAVSAQIQRLEDELGFALFDRTGRSARLNAAG
CHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHH
RRTVERAEELLTAYARLADQGPAAEDRGLLRIGAIASAQTALLVRAIVPFRERAPGWRVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEE
VIPGVSLNLLAQVDSGEVDGAVLIRPPFALPAELTWRALVHEPFVLLVPRALRHEQARVL
EECCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHEECCHHHHHHHHHHH
LRREPFVRYDRNSFGGRIVDRWLRKVRLSVHDVIELDELQAIVELVGCGVGVALVPLASA
HHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LRLPRTVAALPLGDEPPMREIGYVERAGARPDAAAAFAECLAAAVREPAAAPPRRGRSAA
HHCCHHHEECCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
S
C
>Mature Secondary Structure
MIRELKTFLSVVRHGTFARAGAQVGLTQSAVSAQIQRLEDELGFALFDRTGRSARLNAAG
CHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHH
RRTVERAEELLTAYARLADQGPAAEDRGLLRIGAIASAQTALLVRAIVPFRERAPGWRVR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCEEE
VIPGVSLNLLAQVDSGEVDGAVLIRPPFALPAELTWRALVHEPFVLLVPRALRHEQARVL
EECCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHEECCHHHHHHHHHHH
LRREPFVRYDRNSFGGRIVDRWLRKVRLSVHDVIELDELQAIVELVGCGVGVALVPLASA
HHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LRLPRTVAALPLGDEPPMREIGYVERAGARPDAAAAFAECLAAAVREPAAAPPRRGRSAA
HHCCHHHEECCCCCCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]