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The map label for this gene is nhaK [H]

Identifier: 238025046

GI number: 238025046

Start: 2136052

End: 2137635

Strand: Reverse

Name: nhaK [H]

Synonym: bglu_2g17030

Alternate gene names: 238025046

Gene position: 2137635-2136052 (Counterclockwise)

Preceding gene: 238025047

Following gene: 238025045

Centisome position: 75.61

GC content: 71.4

Gene sequence:

>1584_bases
GTGTCCGCCGTGTCCGTCTTCAAACTGGTCCTGCTGTCGTTTGCCGCGATCGTCGTGCTCGAGCTCGTCGCCAAGAAGCT
GCGGCTGCCGCCGGCCGCCGCGCTGCTGGTGGGCGGCGCGGGCATCGCGTTCGTGCCGGGCCTGCCGCCCGTCAATCTCG
ATCCCGATCTGGTGCTGATCGTGTTCCTGCCGCCGCTGCTGGTGGACGGCGCGTATTTCTCGGTCTGGGAGGAGTTCAAG
CGCAACCTGGGCGGCATCATGCTGCTGGCGATCGGCGCGGTGGTGTTCACCACGCTCGCGGTGGGCGTGGCCGTGCATTG
GGCCGTGCCGGCGCTGCCGTGGGCGGCCTGCTTCACGCTCGGCGCGATCGTCTCGCCGCCCGATGCGGTGGCCGCCAAGG
CCGTGCTCGAACGGGTCGCGCTGCCGCGCCGGCTGATGGTGCTGCTCGAAGGCGAGAGCCTGCTCAACGACGCGGCCGGC
CTGGTGCTGTTCCGCTTCGCGGTGGCCGCCGCGCTGACCGGCGCGTTCAGCTTCGAGGGCGCGGTGGTGCGCTTCGCGGA
GCTCGCGCTGGGCGGCGTGGCGGTGGGCTTCATCATCGGCTGGCTGCTGATCCGGTTCATTCGGTTGTTGTCCGACGAAT
ACCTGATCGTCACGACCGCCGTGCTCGGCGGCTGGGTCAGCTACATCGCCGGCGAGACGCTGGAGGTGTCGGGCTTGATC
TCGGCCGTCACGATGGGCATGATGCTCGGCTGGCATCAGCACGAGGTCTTCAGCGCCACGGTGCGGGTCCGCTCCACGGC
GTTCTGGCAGATCATGGTGTTCCTGCTGGAGGCGCTGGTGTTCGTGCTGATCGGGCTGTCGCTGCGCGGCGTGATGCTGC
GCCTGGGCGGCTTCGGCGCGGTGTTCGCCACCATGACGCCGGCCCTGCTCGCGGTGCTGGCCGCCGTGATCGGCTCGCGC
TTCGTCTGGGTGTTCGCGGTCGAGGCGCTGAAGCTGCCGCGCCGCTGGCTCGGCCACGCGCAGCCGCGCGCCGACTGGCG
CGCGGCCACCGTGATGAGCTGGGCCGGCATGCGTGGGGTGGTGACGCTGGCCATCGCGCTGTCGCTGCCCGAGGCGATGC
CGGGCCGCGACATGATCCTGGTGGCCGCGTTCGCGGTGATCCTGGTCACGGTGCTGCTGCAGGGGACCACCATCGGCCCG
CTGATCCGGCTGGTCGCGCCGCGCGATGCCCATGGGCCGGACGCGCGCCACCTGAGCGGGCCGCAGGCCTGGGCCCGGCT
CGCGCGCGCGCAGCTCGCGGCGATCGAGCCGCTGGTGCGCGACGCCGCCGGCAAGGTCGTGCATCCGCGCCTGCTCGAGC
AGTACACCTACCGCGCGGCGATGGCCGAGCGCTTCGAGCACGCCGCCGCGTTCCCGGCGCAGGACGTCCACGCGCACTAC
GACGTGGTGCTCGCGGCGGTCTCGGCCGGGCGTGCCGAGATGCTGAAGATGCACCGCGGCGGGCTGATCCACGACGAGAT
CCTGCATGAGCTGGAACACGACCTCGACCTGCAGGAAGTCACGGCGCGCCACGCCATGGAATGA

Upstream 100 bases:

>100_bases
GGGTGCGCCCCGCCCCGCCGGCGCTTATCACCGTGGCGCGACGCGTTGTGGTGTAATCGCGCGGCCGCAAGCCGCCATTC
ATCCGCGTGAGGGAGTGCCC

Downstream 100 bases:

>100_bases
GCGGCGCGGCGGCGCCGGTTGCGCCGCCTGCAGCGCGCGCCCCGATCTCCTACAATCGAACCCATCGCCCGCCGCGCCGC
GCGCCTCTGGCCTCGCTTCC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSAVSVFKLVLLSFAAIVVLELVAKKLRLPPAAALLVGGAGIAFVPGLPPVNLDPDLVLIVFLPPLLVDGAYFSVWEEFK
RNLGGIMLLAIGAVVFTTLAVGVAVHWAVPALPWAACFTLGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFSFEGAVVRFAELALGGVAVGFIIGWLLIRFIRLLSDEYLIVTTAVLGGWVSYIAGETLEVSGLI
SAVTMGMMLGWHQHEVFSATVRVRSTAFWQIMVFLLEALVFVLIGLSLRGVMLRLGGFGAVFATMTPALLAVLAAVIGSR
FVWVFAVEALKLPRRWLGHAQPRADWRAATVMSWAGMRGVVTLAIALSLPEAMPGRDMILVAAFAVILVTVLLQGTTIGP
LIRLVAPRDAHGPDARHLSGPQAWARLARAQLAAIEPLVRDAAGKVVHPRLLEQYTYRAAMAERFEHAAAFPAQDVHAHY
DVVLAAVSAGRAEMLKMHRGGLIHDEILHELEHDLDLQEVTARHAME

Sequences:

>Translated_527_residues
MSAVSVFKLVLLSFAAIVVLELVAKKLRLPPAAALLVGGAGIAFVPGLPPVNLDPDLVLIVFLPPLLVDGAYFSVWEEFK
RNLGGIMLLAIGAVVFTTLAVGVAVHWAVPALPWAACFTLGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFSFEGAVVRFAELALGGVAVGFIIGWLLIRFIRLLSDEYLIVTTAVLGGWVSYIAGETLEVSGLI
SAVTMGMMLGWHQHEVFSATVRVRSTAFWQIMVFLLEALVFVLIGLSLRGVMLRLGGFGAVFATMTPALLAVLAAVIGSR
FVWVFAVEALKLPRRWLGHAQPRADWRAATVMSWAGMRGVVTLAIALSLPEAMPGRDMILVAAFAVILVTVLLQGTTIGP
LIRLVAPRDAHGPDARHLSGPQAWARLARAQLAAIEPLVRDAAGKVVHPRLLEQYTYRAAMAERFEHAAAFPAQDVHAHY
DVVLAAVSAGRAEMLKMHRGGLIHDEILHELEHDLDLQEVTARHAME
>Mature_526_residues
SAVSVFKLVLLSFAAIVVLELVAKKLRLPPAAALLVGGAGIAFVPGLPPVNLDPDLVLIVFLPPLLVDGAYFSVWEEFKR
NLGGIMLLAIGAVVFTTLAVGVAVHWAVPALPWAACFTLGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAGL
VLFRFAVAAALTGAFSFEGAVVRFAELALGGVAVGFIIGWLLIRFIRLLSDEYLIVTTAVLGGWVSYIAGETLEVSGLIS
AVTMGMMLGWHQHEVFSATVRVRSTAFWQIMVFLLEALVFVLIGLSLRGVMLRLGGFGAVFATMTPALLAVLAAVIGSRF
VWVFAVEALKLPRRWLGHAQPRADWRAATVMSWAGMRGVVTLAIALSLPEAMPGRDMILVAAFAVILVTVLLQGTTIGPL
IRLVAPRDAHGPDARHLSGPQAWARLARAQLAAIEPLVRDAAGKVVHPRLLEQYTYRAAMAERFEHAAAFPAQDVHAHYD
VVLAAVSAGRAEMLKMHRGGLIHDEILHELEHDLDLQEVTARHAME

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=469, Percent_Identity=25.3731343283582, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI15529998, Length=394, Percent_Identity=24.1116751269036, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI27734935, Length=414, Percent_Identity=23.1884057971014, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41872703, Length=430, Percent_Identity=23.953488372093, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI294997330, Length=408, Percent_Identity=23.2843137254902, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI110227626, Length=408, Percent_Identity=23.2843137254902, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI5454070, Length=405, Percent_Identity=23.2098765432099, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194239733, Length=428, Percent_Identity=23.8317757009346, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI14211919, Length=375, Percent_Identity=23.2, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI27777632, Length=411, Percent_Identity=25.0608272506083, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI4759144, Length=380, Percent_Identity=25.7894736842105, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790501, Length=510, Percent_Identity=30.1960784313725, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71980847, Length=405, Percent_Identity=22.7160493827161, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71990932, Length=429, Percent_Identity=22.6107226107226, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71990924, Length=429, Percent_Identity=22.6107226107226, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71999817, Length=457, Percent_Identity=22.5382932166302, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71999819, Length=457, Percent_Identity=22.5382932166302, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71999821, Length=457, Percent_Identity=22.5382932166302, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25147678, Length=503, Percent_Identity=22.4652087475149, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71987535, Length=485, Percent_Identity=19.3814432989691, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992101, Length=379, Percent_Identity=24.0105540897098, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992107, Length=379, Percent_Identity=24.0105540897098, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987537, Length=485, Percent_Identity=19.3814432989691, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=402, Percent_Identity=22.8855721393035, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71987559, Length=438, Percent_Identity=20.5479452054795, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=429, Percent_Identity=24.7086247086247, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71987545, Length=438, Percent_Identity=20.5479452054795, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=429, Percent_Identity=24.7086247086247, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320663, Length=346, Percent_Identity=24.2774566473988, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221510734, Length=421, Percent_Identity=24.9406175771971, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221510738, Length=381, Percent_Identity=25.9842519685039, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221510736, Length=381, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221510732, Length=381, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585580, Length=381, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585578, Length=381, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221510740, Length=381, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221473212, Length=363, Percent_Identity=25.068870523416, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281364513, Length=363, Percent_Identity=25.068870523416, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221473222, Length=363, Percent_Identity=25.068870523416, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221473215, Length=363, Percent_Identity=25.068870523416, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360447, Length=369, Percent_Identity=22.2222222222222, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56479; Mature: 56348

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVSVFKLVLLSFAAIVVLELVAKKLRLPPAAALLVGGAGIAFVPGLPPVNLDPDLVLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEECCCCCCCCCCCCEEEH
VFLPPLLVDGAYFSVWEEFKRNLGGIMLLAIGAVVFTTLAVGVAVHWAVPALPWAACFTL
EEHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAGLVLFRFAVAAALTGAFSFEG
HCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AVVRFAELALGGVAVGFIIGWLLIRFIRLLSDEYLIVTTAVLGGWVSYIAGETLEVSGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHH
SAVTMGMMLGWHQHEVFSATVRVRSTAFWQIMVFLLEALVFVLIGLSLRGVMLRLGGFGA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VFATMTPALLAVLAAVIGSRFVWVFAVEALKLPRRWLGHAQPRADWRAATVMSWAGMRGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCHHHH
VTLAIALSLPEAMPGRDMILVAAFAVILVTVLLQGTTIGPLIRLVAPRDAHGPDARHLSG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCC
PQAWARLARAQLAAIEPLVRDAAGKVVHPRLLEQYTYRAAMAERFEHAAAFPAQDVHAHY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DVVLAAVSAGRAEMLKMHRGGLIHDEILHELEHDLDLQEVTARHAME
HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
SAVSVFKLVLLSFAAIVVLELVAKKLRLPPAAALLVGGAGIAFVPGLPPVNLDPDLVLI
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEECCCCCCCCCCCCEEEH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HHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA