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The map label for this gene is kynU [H]

Identifier: 238024570

GI number: 238024570

Start: 1498554

End: 1499699

Strand: Reverse

Name: kynU [H]

Synonym: bglu_2g11770

Alternate gene names: 238024570

Gene position: 1499699-1498554 (Counterclockwise)

Preceding gene: 238024571

Following gene: 238024569

Centisome position: 53.04

GC content: 71.47

Gene sequence:

>1146_bases
ATGGCCGACTCTTCTCTCTCGAACGGCGACGATGTCAGCGGCTGGCTGATGTATCACTCGGTCGGCGTCTATCCGGGCCA
GCGGGCAGCCGTGGCCGAGGCGCTCGCGCGCTTCACCGCCGACTGGTACGCGCCCGACGATCGCCGCTGGCGCATCGGGC
TCGCCGCGCGCGACGCGCTGCTGTCGAACTGGGCGACGCTGATCGGCGCGGACCCCGCGCAGGTGTTCGGCGCGCAGAAC
GTGACCGACGTGTTCGCGCGCTTCCTCGACGGCCTGGACGTCGCCGCGCTCGCCGGACGCACCGTGCTGGTCGCCGCGGA
CTGCTTTCCGAGCCTGCATTTCCTGCTACGCGGCGTGGCCGCGCGCTACGGCTTCGCGCTGAAGACCGTGCCCGTGCGGG
CGGGCGACGCCTACGTGCGCGACGAAGACTTCATCGCCGCCTGGAGTCCCGACGTCGGCCTCGCACTGATCACCTGGGTG
TCGTCGCTGACTTCGAAGCGTGCGGACCTTGCCGCGCTGACGGCCCATGCGCGCAGCCGCGACAGCCTGGTGGCCGTCGA
CATCACGCAAGGCGCCGGCATCCTGCCGTTCGATCTGGGGCAGACGCCGGTCGACTTCGTCTGCGGCTCCACCCTCAAGT
GGCTGTGCGGCGCACCCGGCACCGGGCTCGGCTATCTCGCGCCGCACCGGCTCGCCGCCGGGATGCAGCCGCCGGTGCGC
GGTTGGTTCAGCCAGCCCGATCCGTTCAACTGGGACCTCGATGCCTTCGCCTATGCGCCGGACGCGCGTCGCTTCGACAC
CGGCACGCCGTCGTTGCTGCCGTTCGTCGCCTCGAAACCCGGTTTCGACTGGCTGCTCGCACAGCCGCCCGGCACGCTGC
GCGCGCACAATCTCGCGCTGGGCCGCCAGTTGATCGAGATCCCCGAGGGGCGCGGTTACCGGCTGCTGTCGCCGCGCGAC
GACGCTGCGCGCGGCGGCAGCATCATGGTGCAGACGCCCGCGCATCTCGATCCGCAACAGGTGGTCGGCATACTGGCCGC
CCAGCGCGTCCTGATCGATTCGCGCGGCCGCACGCTGCGCCTGTCTCCGGGCGCCGGCACCACCATCGCCGGTATCGAGC
GCGTCGCCGCGCATCTGCCGCGATGA

Upstream 100 bases:

>100_bases
GGCTGCGCCGCGCTCAGCCTCGCATGCATTGGCGTCTACCAGCGCTGCGTCGACAAGCATCTGTGAGGTCCGAACCTCAC
GCTCCCACGGGACCACGGTC

Downstream 100 bases:

>100_bases
GGGCGCGCGGCGCCAGGCGTTCGCGCCTTGCCGGCAAGGCATGCCGTGTGGGGCGAGCGGGCCGCCTCGGGCCGCCTGGT
GAACCCCACGCCTCCTGCCT

Product: class V aminotransferase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MADSSLSNGDDVSGWLMYHSVGVYPGQRAAVAEALARFTADWYAPDDRRWRIGLAARDALLSNWATLIGADPAQVFGAQN
VTDVFARFLDGLDVAALAGRTVLVAADCFPSLHFLLRGVAARYGFALKTVPVRAGDAYVRDEDFIAAWSPDVGLALITWV
SSLTSKRADLAALTAHARSRDSLVAVDITQGAGILPFDLGQTPVDFVCGSTLKWLCGAPGTGLGYLAPHRLAAGMQPPVR
GWFSQPDPFNWDLDAFAYAPDARRFDTGTPSLLPFVASKPGFDWLLAQPPGTLRAHNLALGRQLIEIPEGRGYRLLSPRD
DAARGGSIMVQTPAHLDPQQVVGILAAQRVLIDSRGRTLRLSPGAGTTIAGIERVAAHLPR

Sequences:

>Translated_381_residues
MADSSLSNGDDVSGWLMYHSVGVYPGQRAAVAEALARFTADWYAPDDRRWRIGLAARDALLSNWATLIGADPAQVFGAQN
VTDVFARFLDGLDVAALAGRTVLVAADCFPSLHFLLRGVAARYGFALKTVPVRAGDAYVRDEDFIAAWSPDVGLALITWV
SSLTSKRADLAALTAHARSRDSLVAVDITQGAGILPFDLGQTPVDFVCGSTLKWLCGAPGTGLGYLAPHRLAAGMQPPVR
GWFSQPDPFNWDLDAFAYAPDARRFDTGTPSLLPFVASKPGFDWLLAQPPGTLRAHNLALGRQLIEIPEGRGYRLLSPRD
DAARGGSIMVQTPAHLDPQQVVGILAAQRVLIDSRGRTLRLSPGAGTTIAGIERVAAHLPR
>Mature_380_residues
ADSSLSNGDDVSGWLMYHSVGVYPGQRAAVAEALARFTADWYAPDDRRWRIGLAARDALLSNWATLIGADPAQVFGAQNV
TDVFARFLDGLDVAALAGRTVLVAADCFPSLHFLLRGVAARYGFALKTVPVRAGDAYVRDEDFIAAWSPDVGLALITWVS
SLTSKRADLAALTAHARSRDSLVAVDITQGAGILPFDLGQTPVDFVCGSTLKWLCGAPGTGLGYLAPHRLAAGMQPPVRG
WFSQPDPFNWDLDAFAYAPDARRFDTGTPSLLPFVASKPGFDWLLAQPPGTLRAHNLALGRQLIEIPEGRGYRLLSPRDD
AARGGSIMVQTPAHLDPQQVVGILAAQRVLIDSRGRTLRLSPGAGTTIAGIERVAAHLPR

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 40759; Mature: 40628

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSSLSNGDDVSGWLMYHSVGVYPGQRAAVAEALARFTADWYAPDDRRWRIGLAARDAL
CCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
LSNWATLIGADPAQVFGAQNVTDVFARFLDGLDVAALAGRTVLVAADCFPSLHFLLRGVA
HHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHH
ARYGFALKTVPVRAGDAYVRDEDFIAAWSPDVGLALITWVSSLTSKRADLAALTAHARSR
HHHCEEEEEEEEECCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSLVAVDITQGAGILPFDLGQTPVDFVCGSTLKWLCGAPGTGLGYLAPHRLAAGMQPPVR
CCEEEEEECCCCCCCEECCCCCCHHHHHCCHHHHHHCCCCCCCCCCCHHHHHCCCCCCHH
GWFSQPDPFNWDLDAFAYAPDARRFDTGTPSLLPFVASKPGFDWLLAQPPGTLRAHNLAL
CCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHH
GRQLIEIPEGRGYRLLSPRDDAARGGSIMVQTPAHLDPQQVVGILAAQRVLIDSRGRTLR
HHHHHCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEECCCCEEE
LSPGAGTTIAGIERVAAHLPR
ECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSSLSNGDDVSGWLMYHSVGVYPGQRAAVAEALARFTADWYAPDDRRWRIGLAARDAL
CCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
LSNWATLIGADPAQVFGAQNVTDVFARFLDGLDVAALAGRTVLVAADCFPSLHFLLRGVA
HHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCCHHHHCCCEEEEEEHHHHHHHHHHHHHH
ARYGFALKTVPVRAGDAYVRDEDFIAAWSPDVGLALITWVSSLTSKRADLAALTAHARSR
HHHCEEEEEEEEECCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DSLVAVDITQGAGILPFDLGQTPVDFVCGSTLKWLCGAPGTGLGYLAPHRLAAGMQPPVR
CCEEEEEECCCCCCCEECCCCCCHHHHHCCHHHHHHCCCCCCCCCCCHHHHHCCCCCCHH
GWFSQPDPFNWDLDAFAYAPDARRFDTGTPSLLPFVASKPGFDWLLAQPPGTLRAHNLAL
CCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHH
GRQLIEIPEGRGYRLLSPRDDAARGGSIMVQTPAHLDPQQVVGILAAQRVLIDSRGRTLR
HHHHHCCCCCCCEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHEECCCCEEE
LSPGAGTTIAGIERVAAHLPR
ECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]