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The map label for this gene is lon [H]

Identifier: 23501984

GI number: 23501984

Start: 1081108

End: 1083546

Strand: Reverse

Name: lon [H]

Synonym: BR1106

Alternate gene names: 23501984

Gene position: 1083546-1081108 (Counterclockwise)

Preceding gene: 23501986

Following gene: 23501983

Centisome position: 51.41

GC content: 56.83

Gene sequence:

>2439_bases
ATGACGGGTATTGAACAGAAAACACCGGTTGGTGGTTCTGAAACGGGTGGTGCGGACGGGCTCTATGCTGTCTTGCCGCT
GCGTGACATCGTCGTCTTTCCCCATATGATCGTCCCGCTTTTTGTGGGCCGCGAAAAATCCATTCGCGCGCTTGAAGAAG
TGATGGGCGTTGACAAGCAGATATTGCTTGCCACCCAGAAGAACGCTGCCGATGACGATCCGGCGCCGGACGCGATCTAT
GAGATTGGTACGATCGCCAATGTGTTGCAGCTTCTGAAACTGCCGGACGGCACCGTCAAGGTGCTGGTCGAAGGCACGGC
ACGCGCCAAAATTTCCAAGTTTACCGATCGTGAAGATTATCACGAGGCTTATGCTGCGGCTCTGCAGGAGCCGGAGGAAG
ATGCTGTCGAGATCGAGGCACTGGCCCGCTCGGTGGTTTCCGACTTTGAAAATTACGTCAAGCTGAACAAGAAGATTTCG
CCGGAAGTGGTTGGCGCGGCCAGCCAGATCGACGATTATTCCAAGCTTGCCGATACGGTTGCCTCGCACCTTGCGATCAA
AATCCCTGAAAAGCAGGAAATGCTGTCGGTTCTTTCGGTGCGCGAGCGCCTTGAGAAAGCCCTTTCCTTCATGGAAGCCG
AAATTTCTGTTCTACAGGTTGAGAAGCGTATTCGCAGCCGCGTCAAGCGCCAGATGGAGAAGACGCAGCGCGAATATTAT
CTCAATGAGCAGATGAAGGCGATCCAGAAGGAGCTTGGCGACAGTGAGGACGGCCGTGATGAAGTGGCCGAAATCGAAGA
GCGCATCACCAAGACCAAGCTCAGCAAGGAAGCGCGCGAAAAAGCTCTGGCCGAGCTGAAGAAACTGCGCAGCATGAGCC
CGATGTCCGCTGAAGCGACGGTGGTTCGCAATTATCTCGACTGGTTGCTCTCCATTCCATGGGGCAAGAAGTCGAAGGTG
AAGCAGGATCTGAACTTTGCGCAGGAAGTGCTGGATGCGGAGCATTTCGGCCTTGGCAAGGTCAAGGAACGCATCGTCGG
ATATCTGGCGGTGCAGGCCCGTTCGACCAAGATCAAGGGTCCGATCCTCTGCCTCGTTGGCCCTCCCGGCGTCGGCAAGA
CCTCGCTTGCGCGCTCGATTGCCAAGGCAACGGGCCGCGAATATGTCCGCATGTCGCTTGGCGGCGTACGCGACGAGGCT
GAAATCCGCGGTCATCGCCGCACCTATATCGGCTCGATGCCCGGCAAGGTCATCCAGTCGATGAAGAAGGCGAAGAAGTC
CAATCCGCTTTTCCTGCTCGATGAAATCGACAAGATGGGCCAGGATTTCCGCGGCGATCCGTCTTCGGCCATGCTGGAGG
TGCTGGACCCGGAACAGAACGCGACCTTCATGGATCACTACCTTGAAGTTGAGTATGATCTATCGAACGTCATGTTCGTG
ACGACCGCCAATACGATGAATATTCCCGGTCCACTTCTGGATCGTATGGAGATCATCCGTATCGCCGGTTACACGGAAGA
CGAAAAGCTGGAGATCGCCAAGCGGCACCTGTTGCCGAAGGCCATCAAGGACCATGCCCTGCAACCGAAGGAGTTTTCGG
TTACGGAAGATGCGCTGCGCAACGTTATCCGCCATTATACGCGGGAAGCGGGCGTGCGTAGCCTTGAACGCGAGGTGATG
ACCCTTGCGCGCAAGGCCGTGACGGAAATCCTGAAGACGAAGAAGAAGTCGGTAAAGATTACCGACAAGAACCTCTCCGA
TTACCTTGGTGTGGAGAAGTTCCGCTTCGGTCAGATCGACGGTGAAGATCAGGTGGGTGTCGTGACTGGCCTTGCCTGGA
CCGAAGTCGGCGGTGAGCTTTTGACCATCGAAGGCGTCATGATGCCGGGTAAGGGCCGCATGACGGTTACGGGTAATCTC
CGTGACGTGATGAAGGAATCGATTTCGGCCGCGGCATCCTATGTCCGCTCGCGCGCGATCGATTTCGGCATCGAGCCTCC
GCTGTTCGACAAGCGCGATATCCACGTGCACGTGCCGGAAGGCGCGACGCCGAAGGATGGTCCTTCTGCCGGTATCGCCA
TGGTTACGGCCATCGTCTCCGTGCTGACGGGTATTCCCGTTCGCAAGGACATCGCCATGACGGGTGAAGTCACGTTGCGC
GGTCGGGTTCTGCCAATCGGCGGGTTGAAGGAAAAGCTGCTTGCGGCCTTGCGCGGCGGTATCAAGAAGGTTCTGATCCC
GGAAGAGAACGCCAAGGATCTGGCGGAAATCCCGGACAATGTGAAGAACAATCTTGAGATCGTTCCGGTATCCCGCGTCG
GTGAAGTGCTGAAGCACACGCTCGTGCGCCAGCCTGAACCGATTGAATGGACCGAGCAGGAGAATCCCACTGCCGTGCCT
CCGGTGGAGGATGAAGCAGGGGCTTCGCTGGCCCATTAA

Upstream 100 bases:

>100_bases
CTCCAAGTATGGACCGAAGCACGCTTTGTGACCTGCCTCACGACAAAAGGGGGCATAGGCGTGGCAGTCGGGTCGGAAGG
CCCGAGAAAGGACTAGTGTT

Downstream 100 bases:

>100_bases
GGGCACTTGATGTGCCCTGATAATCGAAATGCCGGGCTTCAAGCCCGGCATTTCTGTGTTTAACCCCGGTTTTCCGGGGT
TTTTTAGTGTTGACAGGCTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 812; Mature: 811

Protein sequence:

>812_residues
MTGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQILLATQKNAADDDPAPDAIY
EIGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDYHEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKIS
PEVVGAASQIDDYSKLADTVASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYY
LNEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEATVVRNYLDWLLSIPWGKKSKV
KQDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKGPILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEA
EIRGHRRTYIGSMPGKVIQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFV
TTANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALRNVIRHYTREAGVRSLEREVM
TLARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQIDGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNL
RDVMKESISAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLR
GRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHTLVRQPEPIEWTEQENPTAVP
PVEDEAGASLAH

Sequences:

>Translated_812_residues
MTGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQILLATQKNAADDDPAPDAIY
EIGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDYHEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKIS
PEVVGAASQIDDYSKLADTVASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYY
LNEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEATVVRNYLDWLLSIPWGKKSKV
KQDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKGPILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEA
EIRGHRRTYIGSMPGKVIQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFV
TTANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALRNVIRHYTREAGVRSLEREVM
TLARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQIDGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNL
RDVMKESISAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLR
GRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHTLVRQPEPIEWTEQENPTAVP
PVEDEAGASLAH
>Mature_811_residues
TGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQILLATQKNAADDDPAPDAIYE
IGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDYHEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKISP
EVVGAASQIDDYSKLADTVASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYYL
NEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEATVVRNYLDWLLSIPWGKKSKVK
QDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKGPILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEAE
IRGHRRTYIGSMPGKVIQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFVT
TANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALRNVIRHYTREAGVRSLEREVMT
LARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQIDGEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLR
DVMKESISAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLRG
RVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHTLVRQPEPIEWTEQENPTAVPP
VEDEAGASLAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=656, Percent_Identity=42.8353658536585, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI31377667, Length=771, Percent_Identity=37.8728923476005, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=64.9673202614379, Blast_Score=1004, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=700, Percent_Identity=41, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=737, Percent_Identity=33.921302578019, Blast_Score=422, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319449, Length=714, Percent_Identity=39.6358543417367, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI221513036, Length=650, Percent_Identity=43.5384615384615, Blast_Score=534, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=650, Percent_Identity=43.5384615384615, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89796; Mature: 89665

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQ
CCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
ILLATQKNAADDDPAPDAIYEIGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDY
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHH
HEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKISPEVVGAASQIDDYSKLADTV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHH
ASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYY
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEAT
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VVRNYLDWLLSIPWGKKSKVKQDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCC
PILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEAEIRGHRRTYIGSMPGKVIQS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHH
MKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFV
HHHHHCCCCEEEEHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHEEEEECCCCEEEE
TTANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALR
EECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHH
NVIRHYTREAGVRSLEREVMTLARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCHHHCCCCCC
GEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAI
CCCCCEEEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLR
CCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEE
GRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHT
EEEEECCCHHHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHH
LVRQPEPIEWTEQENPTAVPPVEDEAGASLAH
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGIEQKTPVGGSETGGADGLYAVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGVDKQ
CCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCE
ILLATQKNAADDDPAPDAIYEIGTIANVLQLLKLPDGTVKVLVEGTARAKISKFTDREDY
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCHHHH
HEAYAAALQEPEEDAVEIEALARSVVSDFENYVKLNKKISPEVVGAASQIDDYSKLADTV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHH
ASHLAIKIPEKQEMLSVLSVRERLEKALSFMEAEISVLQVEKRIRSRVKRQMEKTQREYY
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNEQMKAIQKELGDSEDGRDEVAEIEERITKTKLSKEAREKALAELKKLRSMSPMSAEAT
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VVRNYLDWLLSIPWGKKSKVKQDLNFAQEVLDAEHFGLGKVKERIVGYLAVQARSTKIKG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEECCCCCCC
PILCLVGPPGVGKTSLARSIAKATGREYVRMSLGGVRDEAEIRGHRRTYIGSMPGKVIQS
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHH
MKKAKKSNPLFLLDEIDKMGQDFRGDPSSAMLEVLDPEQNATFMDHYLEVEYDLSNVMFV
HHHHHCCCCEEEEHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHEEEEECCCCEEEE
TTANTMNIPGPLLDRMEIIRIAGYTEDEKLEIAKRHLLPKAIKDHALQPKEFSVTEDALR
EECCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHH
NVIRHYTREAGVRSLEREVMTLARKAVTEILKTKKKSVKITDKNLSDYLGVEKFRFGQID
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCHHHCCCCCC
GEDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAI
CCCCCEEEECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DFGIEPPLFDKRDIHVHVPEGATPKDGPSAGIAMVTAIVSVLTGIPVRKDIAMTGEVTLR
CCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCEEEE
GRVLPIGGLKEKLLAALRGGIKKVLIPEENAKDLAEIPDNVKNNLEIVPVSRVGEVLKHT
EEEEECCCHHHHHHHHHHCCCEEEECCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHH
LVRQPEPIEWTEQENPTAVPPVEDEAGASLAH
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA