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The map label for this gene is citC [H]

Identifier: 23099622

GI number: 23099622

Start: 2201051

End: 2202319

Strand: Reverse

Name: citC [H]

Synonym: OB2167

Alternate gene names: 23099622

Gene position: 2202319-2201051 (Counterclockwise)

Preceding gene: 23099623

Following gene: 23099621

Centisome position: 60.66

GC content: 37.35

Gene sequence:

>1269_bases
ATGACACAAGCTGAAAAAATCGTAGTAGAAAACGGAAAAATGAACGTACCTGATACGCCAATCATTCCATTTATTGAAGG
AGACGGAACTGGTCCAGATATTTGGGCTTCTGCTCAAAAAGTTATAGAAGCAGCGGTTGATAAAGCGTATGATGGTAAGA
AAAGTATTGAGTGGATGGAAGTATATGCTGGTCAAAAGGCATATGACAAAACTGGCGAATGGTTGCCAAAAGATACACTT
GATAAAATTAATGAATATAAAATTGCTATCAAAGGTCCCTTAACTACACCGATCGGTGGAGGTATTCGTTCCCTTAATGT
AGCATTACGTCAAGAGTTAGATTTATTTACATGTTTACGACCAGTGCGTTACTTTGAAGGAGTACCTTCGCCAGTTAAAC
GTCCAGAAGAAGTAGATATGGTTATTTTCCGTGAAAATACAGAGGATATTTATGCTGGAATAGAATGGCAAAAAGGTTCT
GACGAAGTGAAAAAAGTAATTAACTTCCTAAAAGAAGAAATGGGAGTAAAAAATATTCGCTTCCCAGAAACGTCAGGAAT
TGGTGTAAAACCAGTATCTGAAGAAGGTACAAAACGATTAGTGCGTTCAGCTATTGACTATGCACTTAATGAAGGTCGTA
AAAATGTTACTTTAGTACATAAAGGTAACATCATGAAATTTACAGAAGGTGCTTTTAAAAACTGGGGTTATGAAGTAGCT
GAGCAAGAATACGGTGATAAAGTATTTACTTGGGCAGAGTACGATCGTATTGTAGAAGCAGAAGGTAAGGATGCAGCTAA
TAAAGCACAAGACGAAGCACTTGCTTCTGGTAAAATTCTTGTGAAAGATGCAATTGCTGACATTTTCTTACAACAAGTTC
TTACTCGTCCGAAAGAGTTTGATGTTGTAGCTACGATGAATTTAAATGGTGACTACATTTCTGATGCACTTGCAGCACAA
GTAGGTGGAATTGGAATTGCACCTGGAGCGAACATCAATTATGATACTGGACATGCGATTTTTGAAGCGACACATGGTAC
TGCACCTAAGTATGCGGGATTAGATAAAGTAAATCCATCTTCTGTTATTCTATCCGCTGTACTTATGTTAGAACACTTAG
GTTGGAGAGAAGCTGCAGACTTAATTACGAAATCAATGGACAAGACGATTGGTTCAAAAGTAGTTACGTATGACTTTGCA
CGCCTAATGGATGGAGCAAAAGAGGTTAAATGCTCTGAATTTGGACAAGAACTAATTAAAAATATGTAA

Upstream 100 bases:

>100_bases
CAGGTCCAGAATTACGTGACTATGTTTCTATTGAACAAAGAGGTTAATATAGATAAACTAGAGAAGATACATTGCGAATA
ACATTTGGGAGGTATTATAA

Downstream 100 bases:

>100_bases
AGCATCAAATGGAATGTGCTGTAGGGATAAGAACTAGCTATTCACTTAGAATACTTTCTTCATTCCTACGCCTCCATTTG
AAATTAGATTTTACGATAAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTQAEKIVVENGKMNVPDTPIIPFIEGDGTGPDIWASAQKVIEAAVDKAYDGKKSIEWMEVYAGQKAYDKTGEWLPKDTL
DKINEYKIAIKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRYFEGVPSPVKRPEEVDMVIFRENTEDIYAGIEWQKGS
DEVKKVINFLKEEMGVKNIRFPETSGIGVKPVSEEGTKRLVRSAIDYALNEGRKNVTLVHKGNIMKFTEGAFKNWGYEVA
EQEYGDKVFTWAEYDRIVEAEGKDAANKAQDEALASGKILVKDAIADIFLQQVLTRPKEFDVVATMNLNGDYISDALAAQ
VGGIGIAPGANINYDTGHAIFEATHGTAPKYAGLDKVNPSSVILSAVLMLEHLGWREAADLITKSMDKTIGSKVVTYDFA
RLMDGAKEVKCSEFGQELIKNM

Sequences:

>Translated_422_residues
MTQAEKIVVENGKMNVPDTPIIPFIEGDGTGPDIWASAQKVIEAAVDKAYDGKKSIEWMEVYAGQKAYDKTGEWLPKDTL
DKINEYKIAIKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRYFEGVPSPVKRPEEVDMVIFRENTEDIYAGIEWQKGS
DEVKKVINFLKEEMGVKNIRFPETSGIGVKPVSEEGTKRLVRSAIDYALNEGRKNVTLVHKGNIMKFTEGAFKNWGYEVA
EQEYGDKVFTWAEYDRIVEAEGKDAANKAQDEALASGKILVKDAIADIFLQQVLTRPKEFDVVATMNLNGDYISDALAAQ
VGGIGIAPGANINYDTGHAIFEATHGTAPKYAGLDKVNPSSVILSAVLMLEHLGWREAADLITKSMDKTIGSKVVTYDFA
RLMDGAKEVKCSEFGQELIKNM
>Mature_421_residues
TQAEKIVVENGKMNVPDTPIIPFIEGDGTGPDIWASAQKVIEAAVDKAYDGKKSIEWMEVYAGQKAYDKTGEWLPKDTLD
KINEYKIAIKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRYFEGVPSPVKRPEEVDMVIFRENTEDIYAGIEWQKGSD
EVKKVINFLKEEMGVKNIRFPETSGIGVKPVSEEGTKRLVRSAIDYALNEGRKNVTLVHKGNIMKFTEGAFKNWGYEVAE
QEYGDKVFTWAEYDRIVEAEGKDAANKAQDEALASGKILVKDAIADIFLQQVLTRPKEFDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYDTGHAIFEATHGTAPKYAGLDKVNPSSVILSAVLMLEHLGWREAADLITKSMDKTIGSKVVTYDFAR
LMDGAKEVKCSEFGQELIKNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=405, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI28178821, Length=405, Percent_Identity=27.6543209876543, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI28178816, Length=365, Percent_Identity=28.7671232876712, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4758582, Length=368, Percent_Identity=27.9891304347826, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI28178838, Length=379, Percent_Identity=27.4406332453826, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787381, Length=423, Percent_Identity=64.0661938534279, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1788101, Length=387, Percent_Identity=27.390180878553, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081683, Length=408, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71986051, Length=387, Percent_Identity=33.0749354005168, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI25144293, Length=394, Percent_Identity=28.6802030456853, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17550882, Length=395, Percent_Identity=27.5949367088608, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=368, Percent_Identity=27.1739130434783, Blast_Score=108, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324709, Length=406, Percent_Identity=31.7733990147783, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6322097, Length=376, Percent_Identity=31.1170212765957, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=375, Percent_Identity=30.1333333333333, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24643270, Length=404, Percent_Identity=33.6633663366337, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24643268, Length=404, Percent_Identity=33.6633663366337, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24661184, Length=402, Percent_Identity=31.592039800995, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078635, Length=288, Percent_Identity=29.5138888888889, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI161078633, Length=288, Percent_Identity=29.5138888888889, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24650122, Length=288, Percent_Identity=29.5138888888889, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI161078637, Length=288, Percent_Identity=29.5138888888889, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI161078639, Length=288, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281362242, Length=396, Percent_Identity=27.020202020202, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24648872, Length=396, Percent_Identity=27.020202020202, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI20130355, Length=396, Percent_Identity=24.4949494949495, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46584; Mature: 46452

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAEKIVVENGKMNVPDTPIIPFIEGDGTGPDIWASAQKVIEAAVDKAYDGKKSIEWME
CCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VYAGQKAYDKTGEWLPKDTLDKINEYKIAIKGPLTTPIGGGIRSLNVALRQELDLFTCLR
HHCCCHHHHCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PVRYFEGVPSPVKRPEEVDMVIFRENTEDIYAGIEWQKGSDEVKKVINFLKEEMGVKNIR
HHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
FPETSGIGVKPVSEEGTKRLVRSAIDYALNEGRKNVTLVHKGNIMKFTEGAFKNWGYEVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHCCHHHH
EQEYGDKVFTWAEYDRIVEAEGKDAANKAQDEALASGKILVKDAIADIFLQQVLTRPKEF
HHHCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DVVATMNLNGDYISDALAAQVGGIGIAPGANINYDTGHAIFEATHGTAPKYAGLDKVNPS
CEEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHH
SVILSAVLMLEHLGWREAADLITKSMDKTIGSKVVTYDFARLMDGAKEVKCSEFGQELIK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NM
CC
>Mature Secondary Structure 
TQAEKIVVENGKMNVPDTPIIPFIEGDGTGPDIWASAQKVIEAAVDKAYDGKKSIEWME
CCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VYAGQKAYDKTGEWLPKDTLDKINEYKIAIKGPLTTPIGGGIRSLNVALRQELDLFTCLR
HHCCCHHHHCCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PVRYFEGVPSPVKRPEEVDMVIFRENTEDIYAGIEWQKGSDEVKKVINFLKEEMGVKNIR
HHHHHCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
FPETSGIGVKPVSEEGTKRLVRSAIDYALNEGRKNVTLVHKGNIMKFTEGAFKNWGYEVA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHCCHHHH
EQEYGDKVFTWAEYDRIVEAEGKDAANKAQDEALASGKILVKDAIADIFLQQVLTRPKEF
HHHCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCC
DVVATMNLNGDYISDALAAQVGGIGIAPGANINYDTGHAIFEATHGTAPKYAGLDKVNPS
CEEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHH
SVILSAVLMLEHLGWREAADLITKSMDKTIGSKVVTYDFARLMDGAKEVKCSEFGQELIK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NM
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]