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The map label for this gene is sdhB [H]

Identifier: 23099567

GI number: 23099567

Start: 2145089

End: 2145853

Strand: Reverse

Name: sdhB [H]

Synonym: OB2112

Alternate gene names: 23099567

Gene position: 2145853-2145089 (Counterclockwise)

Preceding gene: 23099568

Following gene: 23099566

Centisome position: 59.11

GC content: 38.95

Gene sequence:

>765_bases
ATGGCTGAACAGAGTAAAGTTACTTTTATTATAACTAGACAAGACGGCCCGGAATCGACTCCTTATGAGGAAACGTTTGA
GATTCCATATAGACAGAATATGAATGTAATATCTGCACTTATGGAAATCAGACAAAATCCTGTTAATAATAAGGGAGAGA
ATACTACACCTGTAATGTGGGACATGAATTGCTTAGAGGAAGTTTGTGGAGCATGTTCTATGGTAATTAATGGGACAGCA
AGGCAATCTTGTGCTGCCTTGGTTGACCAATTAGAGCAACCAATCCGTTTAGAGCCAATGTCTACATTCCCTGTAGTTCG
AGATTTAATTGTCGATCGTGAACGTATGTTTGATGCATTAAAACAAGTTAAAGCTTGGATACCAATTGACGGTACTCATG
ATTTAGGACCAGGTCCACGTATGCCAGAGAATAAACGTCAATGGGCGTATGAATTATCAAAATGTATGACATGCGGAGTA
TGCTTAGAAGCATGTCCAAATGTTAACGATAATTCAAACTTTATTGGACCAGCTGCAATTTCACAAGCTCGTCTATTTAA
CGCACATCCGACTGGTGAAATGAATGCAAGTGACCGATTAAATGGTCTAATGGAAGACGGGGGTATTGATGGATGTGGAA
ATTCACAAAACTGTGTTCAAGTATGTCCGAAAGGTATCCCACTAACAACTTCTATTGCAGCAATGAACCGAGCTACAAAT
ATTCAAGCGTTTAAAAACTTCTTTGGAAGTGACCAAGCGTTATAA

Upstream 100 bases:

>100_bases
ATCGGTTTCTCCTGAGTTTAGCTATGAAGAAGTAGATGTTTCTTTAATTGAACCGCGTAAGCGTGATTATACTACAAAAC
ACTAAGGAGGAGTAATGTAA

Downstream 100 bases:

>100_bases
ATTCGAACATGAAAGACCCTAACCGATGAACAGGCTAGGGTCTTCATCATATAATATGGGAAAGTGGAGGAAGTTACGAT
GAAATCCATTGAGTATATAG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAEQSKVTFIITRQDGPESTPYEETFEIPYRQNMNVISALMEIRQNPVNNKGENTTPVMWDMNCLEEVCGACSMVINGTA
RQSCAALVDQLEQPIRLEPMSTFPVVRDLIVDRERMFDALKQVKAWIPIDGTHDLGPGPRMPENKRQWAYELSKCMTCGV
CLEACPNVNDNSNFIGPAAISQARLFNAHPTGEMNASDRLNGLMEDGGIDGCGNSQNCVQVCPKGIPLTTSIAAMNRATN
IQAFKNFFGSDQAL

Sequences:

>Translated_254_residues
MAEQSKVTFIITRQDGPESTPYEETFEIPYRQNMNVISALMEIRQNPVNNKGENTTPVMWDMNCLEEVCGACSMVINGTA
RQSCAALVDQLEQPIRLEPMSTFPVVRDLIVDRERMFDALKQVKAWIPIDGTHDLGPGPRMPENKRQWAYELSKCMTCGV
CLEACPNVNDNSNFIGPAAISQARLFNAHPTGEMNASDRLNGLMEDGGIDGCGNSQNCVQVCPKGIPLTTSIAAMNRATN
IQAFKNFFGSDQAL
>Mature_253_residues
AEQSKVTFIITRQDGPESTPYEETFEIPYRQNMNVISALMEIRQNPVNNKGENTTPVMWDMNCLEEVCGACSMVINGTAR
QSCAALVDQLEQPIRLEPMSTFPVVRDLIVDRERMFDALKQVKAWIPIDGTHDLGPGPRMPENKRQWAYELSKCMTCGVC
LEACPNVNDNSNFIGPAAISQARLFNAHPTGEMNASDRLNGLMEDGGIDGCGNSQNCVQVCPKGIPLTTSIAAMNRATNI
QAFKNFFGSDQAL

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=235, Percent_Identity=24.2553191489362, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1790596, Length=235, Percent_Identity=27.2340425531915, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786943, Length=244, Percent_Identity=28.2786885245902, Blast_Score=88, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17533915, Length=226, Percent_Identity=24.7787610619469, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322987, Length=247, Percent_Identity=25.1012145748988, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643156, Length=224, Percent_Identity=29.0178571428571, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137106, Length=229, Percent_Identity=26.2008733624454, Blast_Score=87, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28027; Mature: 27896

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
9.4 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
9.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQSKVTFIITRQDGPESTPYEETFEIPYRQNMNVISALMEIRQNPVNNKGENTTPVMW
CCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
DMNCLEEVCGACSMVINGTARQSCAALVDQLEQPIRLEPMSTFPVVRDLIVDRERMFDAL
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KQVKAWIPIDGTHDLGPGPRMPENKRQWAYELSKCMTCGVCLEACPNVNDNSNFIGPAAI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
SQARLFNAHPTGEMNASDRLNGLMEDGGIDGCGNSQNCVQVCPKGIPLTTSIAAMNRATN
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHH
IQAFKNFFGSDQAL
HHHHHHHHCCCCCC
>Mature Secondary Structure 
AEQSKVTFIITRQDGPESTPYEETFEIPYRQNMNVISALMEIRQNPVNNKGENTTPVMW
CCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
DMNCLEEVCGACSMVINGTARQSCAALVDQLEQPIRLEPMSTFPVVRDLIVDRERMFDAL
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KQVKAWIPIDGTHDLGPGPRMPENKRQWAYELSKCMTCGVCLEACPNVNDNSNFIGPAAI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
SQARLFNAHPTGEMNASDRLNGLMEDGGIDGCGNSQNCVQVCPKGIPLTTSIAAMNRATN
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHH
IQAFKNFFGSDQAL
HHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3114423 [H]