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The map label for this gene is sdhA [H]

Identifier: 23099568

GI number: 23099568

Start: 2145869

End: 2147620

Strand: Reverse

Name: sdhA [H]

Synonym: OB2113

Alternate gene names: 23099568

Gene position: 2147620-2145869 (Counterclockwise)

Preceding gene: 23099569

Following gene: 23099567

Centisome position: 59.15

GC content: 39.44

Gene sequence:

>1752_bases
ATGAGTAATCGTAAAGTAGCAGTGGTTGGTGGTGGCTTAGCAGGACTTATGGCTACAATCAAAGCCGCTGAAGCTGGTGT
GAAAGTAGATTTATTTTCTATAGTACCTGTAAAACGCTCTCACTCTGTATGTGCACAAGGTGGAATAAATGGTGCTGTAA
ATACGAAGGGGGAAGGGGATTCTCCTTGGCTACACTTTGATGATACGGTATATGGTGGCGATTTCTTAGCCAATCAACCA
CAGGTAAAAGCGATGTGTGATGCAGCACCCGGCATTATACATATGTTTGACCGCATGGGAGTAATGTTTAACCGTACGCC
AGAAGGTTTACTAGATTTCCGTAGATTCGGTGGGACACAGATGCACCGTACTGCATATGCAGGAGCAACAACAGGACAAC
AATTATTATACGCTTTGGACGAGCAAGTGCGCCGTTACGAAGTGGAAGGATTAGTTACAAAATTTGAAGGATGGGAATTC
CTCGAAGCTGTTATTGATGAGCAAGGTATAGGTAGAGGAATCGTTGCTCAAGATATTAAAACACATGAAATTAAGGCATT
TCGATCGGATGCGACTATATTTGCGACAGGTGGTCCAGGAATAATCTTTGGTAAATCAACGAATTCAATGATTAACACTG
GTTCTGCAGCGAGCAAATTATATCAACAAGGTGCAAAATATGCGAATGGTGAGTTTATCCAAATTCATCCTACTGCGATT
CCAGGTGATGATAAGTTACGTCTCATGAGTGAGTCTGCACGTGGTGAAGGTGGACGTATATGGACGTATAAAGATGGTGA
ACCTTGGTATTTCTTAGAAGAGAAATATCCTGCTTATGGTAACCTTGTGCCTCGTGATATTGCTACTAGAGAGATTTTTG
ATGTCTGTGTAAATCAAAAATTAGGTATTAACGGAGAGAATATGGTTTACCTAGATCTTTCTCATAAAGATTCGAAAGAA
CTTGATATAAAACTTGGTGGTATTATTGAAATCTATGAAAAATTCGTTGGAGAGGATCCTCGCAAAGTTCCAATGAAAAT
TTTCCCTGCAGTGCACTATTCGATGGGCGGACTATGGGTAGATGACAATCAAATGACTAGTATCCCAGGTATTTTTGCTG
CTGGGGAATGTGATTATTCACAGCACGGTGGTAACCGTCTAGGTGCGAATTCACTATTGTCAGCAATTTATGGTGGAATG
GTAGCTGGGCCGAAAGCAATTGATTATATTGATGGTTTAGACCAACATGTAGATGATTTATCTGATGAATTATATCAATC
TCGTGAAAAAGCAGAGCAAGAAAGCTTTAATAAACTCATGAATATGGAAGGTACCGAGAATGCTTACCAAATTCATAAAG
AATTAGGTGAGTGGATGACGGATAATGTTACTGTTGTTCGTGAGAATGAAAAGCTCTTAAAAACTGATGAAAAGATAAAA
GAGCTACTAGATCGTTGGGATAATATTAATATTAATGACACATCTCGTTGGAGCAATCAAGGTGTTATGTTTACACGTCA
ATTGAAAAACATGCTACATCTAGCACGTGTAATAACTATCGGTGCATACAATCGAAATGAAAGTCGTGGAGCTCATTACA
AACCGGAATTTCCAGAACGTAATGATGAAGAGTTCCTGAAGACAACGGTCGCTAAATTCAATCCAGAATCGGTTTCTCCT
GAGTTTAGCTATGAAGAAGTAGATGTTTCTTTAATTGAACCGCGTAAGCGTGATTATACTACAAAACACTAA

Upstream 100 bases:

>100_bases
TTAGGCGTATTCTTAGCAGTGAGCTATCTTGGAATTAGATCATTAATTAAATTTGCTTATGGTGTTTAATTGAAAGAGAA
GGAAGGAGTGAGTGAACAAT

Downstream 100 bases:

>100_bases
GGAGGAGTAATGTAAATGGCTGAACAGAGTAAAGTTACTTTTATTATAACTAGACAAGACGGCCCGGAATCGACTCCTTA
TGAGGAAACGTTTGAGATTC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSNRKVAVVGGGLAGLMATIKAAEAGVKVDLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWLHFDDTVYGGDFLANQP
QVKAMCDAAPGIIHMFDRMGVMFNRTPEGLLDFRRFGGTQMHRTAYAGATTGQQLLYALDEQVRRYEVEGLVTKFEGWEF
LEAVIDEQGIGRGIVAQDIKTHEIKAFRSDATIFATGGPGIIFGKSTNSMINTGSAASKLYQQGAKYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRIWTYKDGEPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDSKE
LDIKLGGIIEIYEKFVGEDPRKVPMKIFPAVHYSMGGLWVDDNQMTSIPGIFAAGECDYSQHGGNRLGANSLLSAIYGGM
VAGPKAIDYIDGLDQHVDDLSDELYQSREKAEQESFNKLMNMEGTENAYQIHKELGEWMTDNVTVVRENEKLLKTDEKIK
ELLDRWDNININDTSRWSNQGVMFTRQLKNMLHLARVITIGAYNRNESRGAHYKPEFPERNDEEFLKTTVAKFNPESVSP
EFSYEEVDVSLIEPRKRDYTTKH

Sequences:

>Translated_583_residues
MSNRKVAVVGGGLAGLMATIKAAEAGVKVDLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWLHFDDTVYGGDFLANQP
QVKAMCDAAPGIIHMFDRMGVMFNRTPEGLLDFRRFGGTQMHRTAYAGATTGQQLLYALDEQVRRYEVEGLVTKFEGWEF
LEAVIDEQGIGRGIVAQDIKTHEIKAFRSDATIFATGGPGIIFGKSTNSMINTGSAASKLYQQGAKYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRIWTYKDGEPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDSKE
LDIKLGGIIEIYEKFVGEDPRKVPMKIFPAVHYSMGGLWVDDNQMTSIPGIFAAGECDYSQHGGNRLGANSLLSAIYGGM
VAGPKAIDYIDGLDQHVDDLSDELYQSREKAEQESFNKLMNMEGTENAYQIHKELGEWMTDNVTVVRENEKLLKTDEKIK
ELLDRWDNININDTSRWSNQGVMFTRQLKNMLHLARVITIGAYNRNESRGAHYKPEFPERNDEEFLKTTVAKFNPESVSP
EFSYEEVDVSLIEPRKRDYTTKH
>Mature_582_residues
SNRKVAVVGGGLAGLMATIKAAEAGVKVDLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPWLHFDDTVYGGDFLANQPQ
VKAMCDAAPGIIHMFDRMGVMFNRTPEGLLDFRRFGGTQMHRTAYAGATTGQQLLYALDEQVRRYEVEGLVTKFEGWEFL
EAVIDEQGIGRGIVAQDIKTHEIKAFRSDATIFATGGPGIIFGKSTNSMINTGSAASKLYQQGAKYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRIWTYKDGEPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDSKEL
DIKLGGIIEIYEKFVGEDPRKVPMKIFPAVHYSMGGLWVDDNQMTSIPGIFAAGECDYSQHGGNRLGANSLLSAIYGGMV
AGPKAIDYIDGLDQHVDDLSDELYQSREKAEQESFNKLMNMEGTENAYQIHKELGEWMTDNVTVVRENEKLLKTDEKIKE
LLDRWDNININDTSRWSNQGVMFTRQLKNMLHLARVITIGAYNRNESRGAHYKPEFPERNDEEFLKTTVAKFNPESVSPE
FSYEEVDVSLIEPRKRDYTTKH

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=543, Percent_Identity=31.1233885819521, Blast_Score=215, Evalue=1e-55,
Organism=Escherichia coli, GI1790597, Length=565, Percent_Identity=32.5663716814159, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1786942, Length=561, Percent_Identity=33.3333333333333, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1788928, Length=550, Percent_Identity=26.9090909090909, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17505833, Length=542, Percent_Identity=31.549815498155, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=541, Percent_Identity=31.9778188539741, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322701, Length=551, Percent_Identity=33.2123411978221, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322416, Length=588, Percent_Identity=30.2721088435374, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17137288, Length=537, Percent_Identity=31.2849162011173, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24655642, Length=537, Percent_Identity=31.2849162011173, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24655647, Length=537, Percent_Identity=31.2849162011173, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24663005, Length=548, Percent_Identity=30.8394160583942, Blast_Score=210, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65098; Mature: 64967

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRKVAVVGGGLAGLMATIKAAEAGVKVDLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWLHFDDTVYGGDFLANQPQVKAMCDAAPGIIHMFDRMGVMFNRTPEGLLDFRRFGGTQ
CCCEEECCCEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCCEECCCHHHHHHHHHCCCCH
MHRTAYAGATTGQQLLYALDEQVRRYEVEGLVTKFEGWEFLEAVIDEQGIGRGIVAQDIK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCC
THEIKAFRSDATIFATGGPGIIFGKSTNSMINTGSAASKLYQQGAKYANGEFIQIHPTAI
HHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
PGDDKLRLMSESARGEGGRIWTYKDGEPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDSKELDIKLGGIIEIYEKFVGEDPRKVPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHCCHHHHCCCCEEE
DDNQMTSIPGIFAAGECDYSQHGGNRLGANSLLSAIYGGMVAGPKAIDYIDGLDQHVDDL
CCCCCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHH
SDELYQSREKAEQESFNKLMNMEGTENAYQIHKELGEWMTDNVTVVRENEKLLKTDEKIK
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
ELLDRWDNININDTSRWSNQGVMFTRQLKNMLHLARVITIGAYNRNESRGAHYKPEFPER
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCC
NDEEFLKTTVAKFNPESVSPEFSYEEVDVSLIEPRKRDYTTKH
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
SNRKVAVVGGGLAGLMATIKAAEAGVKVDLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPWLHFDDTVYGGDFLANQPQVKAMCDAAPGIIHMFDRMGVMFNRTPEGLLDFRRFGGTQ
CCCEEECCCEECCCCCCCCCCHHHHHHCCCHHHHHHHHCCCEECCCHHHHHHHHHCCCCH
MHRTAYAGATTGQQLLYALDEQVRRYEVEGLVTKFEGWEFLEAVIDEQGIGRGIVAQDIK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCC
THEIKAFRSDATIFATGGPGIIFGKSTNSMINTGSAASKLYQQGAKYANGEFIQIHPTAI
HHHHHHCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
PGDDKLRLMSESARGEGGRIWTYKDGEPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDSKELDIKLGGIIEIYEKFVGEDPRKVPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHCCHHHHCCCCEEE
DDNQMTSIPGIFAAGECDYSQHGGNRLGANSLLSAIYGGMVAGPKAIDYIDGLDQHVDDL
CCCCCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHH
SDELYQSREKAEQESFNKLMNMEGTENAYQIHKELGEWMTDNVTVVRENEKLLKTDEKIK
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHH
ELLDRWDNININDTSRWSNQGVMFTRQLKNMLHLARVITIGAYNRNESRGAHYKPEFPER
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCC
NDEEFLKTTVAKFNPESVSPEFSYEEVDVSLIEPRKRDYTTKH
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]