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The map label for this gene is clpX

Identifier: 23099532

GI number: 23099532

Start: 2105644

End: 2106921

Strand: Reverse

Name: clpX

Synonym: OB2077

Alternate gene names: 23099532

Gene position: 2106921-2105644 (Counterclockwise)

Preceding gene: 23099533

Following gene: 23099531

Centisome position: 58.03

GC content: 36.07

Gene sequence:

>1278_bases
ATGTTTAAATTTAATGAGGAAAAAGGACAATTGAAATGTTCCTTTTGTGGAAAAAGTCAGGAGCAAGTAAGGAAACTAGT
TGCCGGACCAGGCGTGTATATATGTGATGAGTGTATAGATCTCTGTACTGAAATCGTAGAAGAAGAATTAGGTACAGAAG
AAGATATGGAAATGAACGAAATTCCAAAACCAAAGGAAATTTGCGATATACTTGATGATTATGTAATCGGTCAAGATAAA
GCAAAGAAGAACCTCTCTGTAGCAGTATATAATCACTATAAACGCGTGAATTCTGGCAAAGGCAACGATGAAGTTGAAAT
TGCTAAAAGTAATATTGCGATGATAGGACCTACTGGTAGTGGTAAAACATTACTTGCACAAACATTGGCTAGAATTATTA
ATGTACCATTTGCAATGGCAGACGCTACTTCTCTAACAGAAGCTGGTTATGTAGGGGAAGATGTTGAGAATATTCTTCTA
AAATTAATTCAAGCTGCCGATTATGATGTAGAGAAAGCGGAAAAAGGTATTATATATATAGATGAGATTGATAAAGTAGC
TCGTAAATCTGAAAATCCATCCATCACTCGTGATGTATCTGGTGAAGGTGTACAGCAAGCATTATTGAAAATTCTTGAAG
GTACTGTAGCTAGTGTTCCACCACAAGGTGGAAGAAAACATCCGCACCAAGAATTTATTCAGATTGATACTACCAATATC
TTATTCATCGTTGGTGGTGCGTTTGATGGTATTGATCAAGTTATCAAGCGCCGTTTAGGTAAGAAAGTAATTGGTTTCGG
TTCTCATGAAAAACAAGAAGATTTAGACACTGGTCAATTACTTTCAAAAGTTCTACCTGAAGATTTATTGCGTTACGGTC
TAATTCCAGAGTTTATCGGACGTATTCCAGTTATTGGAAGCTTAACTCCATTAGACGAAGAGGCGTTAATTGAAATCCTA
ACTAAGCCAAAAAATGCATTAGTTAAACAATATCAAAAATTATTTGAGATTGACCATGTTGAGCTTGAATTTGAGGAAGA
GGCACTACAAGAAATTGCGAAGAAAGCAATTGAACGAAAAACTGGAGCTCGAGGGCTACGATCCATTATTGAAGGTATAA
TTGTTGACGTAATGTTTGACATTCCTTCAAGAGAAGACGTGGATAGATGCATTATTACGAAAGAAACAGTTTCTGATGAT
GATGGTAGTCCGAAACTTGTATTTCGAGACGGCACAGTAAAACTTGGGAATGAAAAGTTACCAAAAGAAAGTGCTTAA

Upstream 100 bases:

>100_bases
ACACTAAAAGGTATATTGTTTTGTTTTTATTTTGTATCTGATATGATGACTATAAAAGTTGATTGCTGAACGATTTCAGC
ACGTTTAGGGGTGAAAAGTA

Downstream 100 bases:

>100_bases
TACAAATTAGGACGGAGATGTAGCAGTTATGTTCAATCTGCCTTCTCCGTCTTTTTTTATCACATACATATGAGAAGCAA
CATTGACACATTTTAATAAT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIDLCTEIVEEELGTEEDMEMNEIPKPKEICDILDDYVIGQDK
AKKNLSVAVYNHYKRVNSGKGNDEVEIAKSNIAMIGPTGSGKTLLAQTLARIINVPFAMADATSLTEAGYVGEDVENILL
KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFDGIDQVIKRRLGKKVIGFGSHEKQEDLDTGQLLSKVLPEDLLRYGLIPEFIGRIPVIGSLTPLDEEALIEIL
TKPKNALVKQYQKLFEIDHVELEFEEEALQEIAKKAIERKTGARGLRSIIEGIIVDVMFDIPSREDVDRCIITKETVSDD
DGSPKLVFRDGTVKLGNEKLPKESA

Sequences:

>Translated_425_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIDLCTEIVEEELGTEEDMEMNEIPKPKEICDILDDYVIGQDK
AKKNLSVAVYNHYKRVNSGKGNDEVEIAKSNIAMIGPTGSGKTLLAQTLARIINVPFAMADATSLTEAGYVGEDVENILL
KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFDGIDQVIKRRLGKKVIGFGSHEKQEDLDTGQLLSKVLPEDLLRYGLIPEFIGRIPVIGSLTPLDEEALIEIL
TKPKNALVKQYQKLFEIDHVELEFEEEALQEIAKKAIERKTGARGLRSIIEGIIVDVMFDIPSREDVDRCIITKETVSDD
DGSPKLVFRDGTVKLGNEKLPKESA
>Mature_425_residues
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIDLCTEIVEEELGTEEDMEMNEIPKPKEICDILDDYVIGQDK
AKKNLSVAVYNHYKRVNSGKGNDEVEIAKSNIAMIGPTGSGKTLLAQTLARIINVPFAMADATSLTEAGYVGEDVENILL
KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNI
LFIVGGAFDGIDQVIKRRLGKKVIGFGSHEKQEDLDTGQLLSKVLPEDLLRYGLIPEFIGRIPVIGSLTPLDEEALIEIL
TKPKNALVKQYQKLFEIDHVELEFEEEALQEIAKKAIERKTGARGLRSIIEGIIVDVMFDIPSREDVDRCIITKETVSDD
DGSPKLVFRDGTVKLGNEKLPKESA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=322, Percent_Identity=48.4472049689441, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1786642, Length=402, Percent_Identity=63.681592039801, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=44.7619047619048, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=307, Percent_Identity=45.2768729641694, Blast_Score=277, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI71982905, Length=307, Percent_Identity=45.2768729641694, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=411, Percent_Identity=36.9829683698297, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71988660, Length=256, Percent_Identity=37.109375, Blast_Score=164, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6319704, Length=412, Percent_Identity=39.0776699029126, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24648291, Length=312, Percent_Identity=47.7564102564103, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24648289, Length=312, Percent_Identity=47.7564102564103, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_OCEIH (Q8CXB8)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692998.1
- ProteinModelPortal:   Q8CXB8
- GeneID:   1015947
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2077
- NMPDR:   fig|221109.1.peg.2075
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   OIHE221109:OB2077-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 47029; Mature: 47029

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIDLCTEIVEEELGTEEDMEMNE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHC
IPKPKEICDILDDYVIGQDKAKKNLSVAVYNHYKRVNSGKGNDEVEIAKSNIAMIGPTGS
CCCHHHHHHHHHHHHCCCCHHHCCCEEEEHHHHHHHCCCCCCCCEEEEECCEEEECCCCC
GKTLLAQTLARIINVPFAMADATSLTEAGYVGEDVENILLKLIQAADYDVEKAEKGIIYI
CHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEE
DEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEEECCEE
LFIVGGAFDGIDQVIKRRLGKKVIGFGSHEKQEDLDTGQLLSKVLPEDLLRYGLIPEFIG
EEEECCCHHHHHHHHHHHHCCHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCHHHHC
RIPVIGSLTPLDEEALIEILTKPKNALVKQYQKLFEIDHVELEFEEEALQEIAKKAIERK
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHH
TGARGLRSIIEGIIVDVMFDIPSREDVDRCIITKETVSDDDGSPKLVFRDGTVKLGNEKL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHCCCCCCCCEEEEECCCEEECCCCC
PKESA
CCCCC
>Mature Secondary Structure
MFKFNEEKGQLKCSFCGKSQEQVRKLVAGPGVYICDECIDLCTEIVEEELGTEEDMEMNE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHC
IPKPKEICDILDDYVIGQDKAKKNLSVAVYNHYKRVNSGKGNDEVEIAKSNIAMIGPTGS
CCCHHHHHHHHHHHHCCCCHHHCCCEEEEHHHHHHHCCCCCCCCEEEEECCEEEECCCCC
GKTLLAQTLARIINVPFAMADATSLTEAGYVGEDVENILLKLIQAADYDVEKAEKGIIYI
CHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEEE
DEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFIQIDTTNI
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEEECCEE
LFIVGGAFDGIDQVIKRRLGKKVIGFGSHEKQEDLDTGQLLSKVLPEDLLRYGLIPEFIG
EEEECCCHHHHHHHHHHHHCCHHCCCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCHHHHC
RIPVIGSLTPLDEEALIEILTKPKNALVKQYQKLFEIDHVELEFEEEALQEIAKKAIERK
CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHH
TGARGLRSIIEGIIVDVMFDIPSREDVDRCIITKETVSDDDGSPKLVFRDGTVKLGNEKL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEHHHCCCCCCCCEEEEECCCEEECCCCC
PKESA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376