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The map label for this gene is lon1 [H]

Identifier: 23099531

GI number: 23099531

Start: 2103150

End: 2105468

Strand: Reverse

Name: lon1 [H]

Synonym: OB2076

Alternate gene names: 23099531

Gene position: 2105468-2103150 (Counterclockwise)

Preceding gene: 23099532

Following gene: 23099530

Centisome position: 57.99

GC content: 34.58

Gene sequence:

>2319_bases
ATGACAACAGAATTTAAACAGATTCCCCTCTTGCCATTACGTGGATTGTTAGTTTTCCCTTCAATGGTTCTACATCTTGA
TGTGGGGCGTGATAAATCAATTGCCTCTATTGAAAGGTCTATGGTGGAAGACGAATACATATTCTTAGCTGCCCAAAAGA
AAGGAAATATAGAAGATCCTCAACCAGAAGATATATATACGATTGGTACAGTAGCAAAAGTTAAGCAAATGCTAAAACTT
CCTAATGGAACGAATCGTGTGTTAGTAGAAGGTATGTATCGAGGGAAATTAATACGTCACATTGATAGTGAAAATGAATA
TTTAGTAGAAGTTGAGAAATTAGAGGAAACAAAAAGTGAAGAAAATGAGATAGAAGCTTTAATGAGAACCTTACTAGACT
ATTTTAAACAATATGTTAAAGTATCACGTAAAGTAACAGAAGATACATTTGAATCAGTAGGTGATATCGAAGACCCAGGT
AGGCTTTCGGATATAATAACATCTCATATCGCTTTAAAAGTACCAGAAAAACAAAAGCTTTTAGAGACACTTAATATAAA
TGAGCGAATTAAAAAATTATTAAAGATTATTTCTAATGAAAAGAAAGTATTAGATATAGAGAAAAAAATAGGGCAACGAG
TAAAATCTTCAATGGAAAAAACACAAAAAGAATACTACCTAAGAGAACAATTAAAGGCGATACAAAAAGAATTGGGTGAA
CGGGATGGAAAGGCAACAGATTTAGATCAGTTGCATTCGAAAATTGAAAAATCGGACATGCCTGACCATATTCGTAATGT
AGCGTTAAAAGAATTAGGTAGATATGAAAAAGTGCCTCAATCATCAGCTGAGAGTTCCGTGATTAGAAATTACATTGAAT
GGCTTATCGCATTACCTTGGCAAAACAAAACGAAAGATAATATTAATATTAAAAAAGCAGAGAAGGTATTGAATAGAGAT
CATTATGGATTAGATAAAGTAAAAGAACGAATTCTTGAGTATTTAGCTGTTCAGAAGTTAACTAACTCTATAAAAGGACC
TATTCTGTGTTTAGTTGGACCACCTGGTGTTGGAAAAACTTCTTTAGCAAAATCTATTTCGAATTCCATCAATAGAAAGT
TTGTGAGGATCTCTTTAGGTGGGGTAAGAGACGAAGCGGAAATTCGTGGGCATAGAAGAACTTATATTGGTGCAATGCCA
GGTAGAATCATGCAAGGAATGAAAAAAGCAGAAACCATTAATCCAGTCTTTTTACTTGATGAAATTGATAAGATGTCAAA
TGATTTTCGTGGTGATCCATCTTCAGCGATGTTAGAAGTATTAGATCCAGAACAAAATCATGCGTTTAGTGATCACTTTA
TAGAAGAGACGTATGATTTATCAAATGTTCTTTTTATTGCTACAGCGAATAATGTATCAAGTATTCCTGAGCCTTTACTT
GATCGAATGGAACTAATCTCTATCGCGGGCTATACAGAAGTGGAAAAACTCCATATTGCGAAGGAACATTTAATTCCAAA
GCAATTACAAGAAAATGGATTAACGAAAAGCAAATTACAAATGCGTGAAACGGCAGTAATGAAACTTATTCGAAGATATA
CTCGTGAAGCAGGAGTAAGGGGATTAGAAAGACAAATAGCTACCTTATGCAGAAAAGCAGCTAAAACATTAATAACGGAT
ACATCGAAAGAACGTATTATTATAACAGAACATACTATCGAGGATTATTTAGGCAAACCTTATTTCCGATATGGATTGAT
GGAACAAGAAAATCAAATTGGTGCAGCAACTGGGTTAGCTTATACCTCGGCAGGAGGGGATATACTTTCAATCGAAGTAA
GTCACTATCCTGGTAAGGGAAAATTAACATTAACTGGCCAATTAGGAGATGTTATGCAAGAATCTGCACAAGCTGCATTT
AGTTATGTGCGTTCAAGAACGAATCATTTTCATATTGAACCAGATTTTTATGAGAAATATGATATTCATATTCACGTTCC
AGCTGGAGCTACACCAAAAGATGGACCATCTGCTGGAATAACTATTGCCACGGCTCTAGTAAGTTCATTAACAGGCAGGG
CAATTAAAAAGGAAGTTGGAATGACTGGTGAAATCACTTTACGCGGTAGAGTATTGCCAATCGGAGGATTAAAAGAAAAG
GCACTAAGTGCTCACCGTGCTGGATTAACTACTATAATAATTCCTGATGAAAATGAAAAGGATATTGAGAACATTCCAGA
AAGTGTACGAAATGAATTAACATTTATACCAGTAAAACATTTAGACGAAGTTTTAGAACAAGCACTCGTGGAGGAATAA

Upstream 100 bases:

>100_bases
AGCAACATTGACACATTTTAATAATAATTGAAAAACAATAGTATTTAATATAACTTACATATTGCTTTTATTTCTTGATT
CAATAGTGGAGGTACACAAA

Downstream 100 bases:

>100_bases
AAAATGAAAGTTAACCATGCTGAAATTGTCATTAGTGCGGTAAGTAAAAAGCAGTATCCAGAAGATCAATTACCGGAAAT
TGCTTTAGCTGGAAGGTCTA

Product: ATP-dependent proteinase La 1

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MTTEFKQIPLLPLRGLLVFPSMVLHLDVGRDKSIASIERSMVEDEYIFLAAQKKGNIEDPQPEDIYTIGTVAKVKQMLKL
PNGTNRVLVEGMYRGKLIRHIDSENEYLVEVEKLEETKSEENEIEALMRTLLDYFKQYVKVSRKVTEDTFESVGDIEDPG
RLSDIITSHIALKVPEKQKLLETLNINERIKKLLKIISNEKKVLDIEKKIGQRVKSSMEKTQKEYYLREQLKAIQKELGE
RDGKATDLDQLHSKIEKSDMPDHIRNVALKELGRYEKVPQSSAESSVIRNYIEWLIALPWQNKTKDNINIKKAEKVLNRD
HYGLDKVKERILEYLAVQKLTNSIKGPILCLVGPPGVGKTSLAKSISNSINRKFVRISLGGVRDEAEIRGHRRTYIGAMP
GRIMQGMKKAETINPVFLLDEIDKMSNDFRGDPSSAMLEVLDPEQNHAFSDHFIEETYDLSNVLFIATANNVSSIPEPLL
DRMELISIAGYTEVEKLHIAKEHLIPKQLQENGLTKSKLQMRETAVMKLIRRYTREAGVRGLERQIATLCRKAAKTLITD
TSKERIIITEHTIEDYLGKPYFRYGLMEQENQIGAATGLAYTSAGGDILSIEVSHYPGKGKLTLTGQLGDVMQESAQAAF
SYVRSRTNHFHIEPDFYEKYDIHIHVPAGATPKDGPSAGITIATALVSSLTGRAIKKEVGMTGEITLRGRVLPIGGLKEK
ALSAHRAGLTTIIIPDENEKDIENIPESVRNELTFIPVKHLDEVLEQALVEE

Sequences:

>Translated_772_residues
MTTEFKQIPLLPLRGLLVFPSMVLHLDVGRDKSIASIERSMVEDEYIFLAAQKKGNIEDPQPEDIYTIGTVAKVKQMLKL
PNGTNRVLVEGMYRGKLIRHIDSENEYLVEVEKLEETKSEENEIEALMRTLLDYFKQYVKVSRKVTEDTFESVGDIEDPG
RLSDIITSHIALKVPEKQKLLETLNINERIKKLLKIISNEKKVLDIEKKIGQRVKSSMEKTQKEYYLREQLKAIQKELGE
RDGKATDLDQLHSKIEKSDMPDHIRNVALKELGRYEKVPQSSAESSVIRNYIEWLIALPWQNKTKDNINIKKAEKVLNRD
HYGLDKVKERILEYLAVQKLTNSIKGPILCLVGPPGVGKTSLAKSISNSINRKFVRISLGGVRDEAEIRGHRRTYIGAMP
GRIMQGMKKAETINPVFLLDEIDKMSNDFRGDPSSAMLEVLDPEQNHAFSDHFIEETYDLSNVLFIATANNVSSIPEPLL
DRMELISIAGYTEVEKLHIAKEHLIPKQLQENGLTKSKLQMRETAVMKLIRRYTREAGVRGLERQIATLCRKAAKTLITD
TSKERIIITEHTIEDYLGKPYFRYGLMEQENQIGAATGLAYTSAGGDILSIEVSHYPGKGKLTLTGQLGDVMQESAQAAF
SYVRSRTNHFHIEPDFYEKYDIHIHVPAGATPKDGPSAGITIATALVSSLTGRAIKKEVGMTGEITLRGRVLPIGGLKEK
ALSAHRAGLTTIIIPDENEKDIENIPESVRNELTFIPVKHLDEVLEQALVEE
>Mature_771_residues
TTEFKQIPLLPLRGLLVFPSMVLHLDVGRDKSIASIERSMVEDEYIFLAAQKKGNIEDPQPEDIYTIGTVAKVKQMLKLP
NGTNRVLVEGMYRGKLIRHIDSENEYLVEVEKLEETKSEENEIEALMRTLLDYFKQYVKVSRKVTEDTFESVGDIEDPGR
LSDIITSHIALKVPEKQKLLETLNINERIKKLLKIISNEKKVLDIEKKIGQRVKSSMEKTQKEYYLREQLKAIQKELGER
DGKATDLDQLHSKIEKSDMPDHIRNVALKELGRYEKVPQSSAESSVIRNYIEWLIALPWQNKTKDNINIKKAEKVLNRDH
YGLDKVKERILEYLAVQKLTNSIKGPILCLVGPPGVGKTSLAKSISNSINRKFVRISLGGVRDEAEIRGHRRTYIGAMPG
RIMQGMKKAETINPVFLLDEIDKMSNDFRGDPSSAMLEVLDPEQNHAFSDHFIEETYDLSNVLFIATANNVSSIPEPLLD
RMELISIAGYTEVEKLHIAKEHLIPKQLQENGLTKSKLQMRETAVMKLIRRYTREAGVRGLERQIATLCRKAAKTLITDT
SKERIIITEHTIEDYLGKPYFRYGLMEQENQIGAATGLAYTSAGGDILSIEVSHYPGKGKLTLTGQLGDVMQESAQAAFS
YVRSRTNHFHIEPDFYEKYDIHIHVPAGATPKDGPSAGITIATALVSSLTGRAIKKEVGMTGEITLRGRVLPIGGLKEKA
LSAHRAGLTTIIIPDENEKDIENIPESVRNELTFIPVKHLDEVLEQALVEE

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=765, Percent_Identity=40.9150326797386, Blast_Score=587, Evalue=1e-167,
Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=42.1052631578947, Blast_Score=535, Evalue=1e-152,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=54.025974025974, Blast_Score=860, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=721, Percent_Identity=38.5575589459085, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=793, Percent_Identity=33.4174022698613, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319449, Length=732, Percent_Identity=38.3879781420765, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=665, Percent_Identity=41.6541353383459, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=665, Percent_Identity=41.6541353383459, Blast_Score=521, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87122; Mature: 86990

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEFKQIPLLPLRGLLVFPSMVLHLDVGRDKSIASIERSMVEDEYIFLAAQKKGNIEDP
CCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
QPEDIYTIGTVAKVKQMLKLPNGTNRVLVEGMYRGKLIRHIDSENEYLVEVEKLEETKSE
CCCCEEEHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCH
ENEIEALMRTLLDYFKQYVKVSRKVTEDTFESVGDIEDPGRLSDIITSHIALKVPEKQKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCHHHHH
LETLNINERIKKLLKIISNEKKVLDIEKKIGQRVKSSMEKTQKEYYLREQLKAIQKELGE
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RDGKATDLDQLHSKIEKSDMPDHIRNVALKELGRYEKVPQSSAESSVIRNYIEWLIALPW
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
QNKTKDNINIKKAEKVLNRDHYGLDKVKERILEYLAVQKLTNSIKGPILCLVGPPGVGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLAKSISNSINRKFVRISLGGVRDEAEIRGHRRTYIGAMPGRIMQGMKKAETINPVFLLD
HHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHHHCCCCCHHHH
EIDKMSNDFRGDPSSAMLEVLDPEQNHAFSDHFIEETYDLSNVLFIATANNVSSIPEPLL
HHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
DRMELISIAGYTEVEKLHIAKEHLIPKQLQENGLTKSKLQMRETAVMKLIRRYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLERQIATLCRKAAKTLITDTSKERIIITEHTIEDYLGKPYFRYGLMEQENQIGAATGLA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCHHHHCCHHCCCCCCHHHCCE
YTSAGGDILSIEVSHYPGKGKLTLTGQLGDVMQESAQAAFSYVRSRTNHFHIEPDFYEKY
EECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEE
DIHIHVPAGATPKDGPSAGITIATALVSSLTGRAIKKEVGMTGEITLRGRVLPIGGLKEK
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHH
ALSAHRAGLTTIIIPDENEKDIENIPESVRNELTFIPVKHLDEVLEQALVEE
HHHHHHCCCEEEEECCCCCCHHHHCCHHHHHCEEEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTEFKQIPLLPLRGLLVFPSMVLHLDVGRDKSIASIERSMVEDEYIFLAAQKKGNIEDP
CCCCCCCCCCHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
QPEDIYTIGTVAKVKQMLKLPNGTNRVLVEGMYRGKLIRHIDSENEYLVEVEKLEETKSE
CCCCEEEHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCCCCEEEEHHHHHHHCCH
ENEIEALMRTLLDYFKQYVKVSRKVTEDTFESVGDIEDPGRLSDIITSHIALKVPEKQKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCHHHHH
LETLNINERIKKLLKIISNEKKVLDIEKKIGQRVKSSMEKTQKEYYLREQLKAIQKELGE
HHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RDGKATDLDQLHSKIEKSDMPDHIRNVALKELGRYEKVPQSSAESSVIRNYIEWLIALPW
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
QNKTKDNINIKKAEKVLNRDHYGLDKVKERILEYLAVQKLTNSIKGPILCLVGPPGVGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
SLAKSISNSINRKFVRISLGGVRDEAEIRGHRRTYIGAMPGRIMQGMKKAETINPVFLLD
HHHHHHHHHHCCEEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHHHCCCCCHHHH
EIDKMSNDFRGDPSSAMLEVLDPEQNHAFSDHFIEETYDLSNVLFIATANNVSSIPEPLL
HHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHH
DRMELISIAGYTEVEKLHIAKEHLIPKQLQENGLTKSKLQMRETAVMKLIRRYTREAGVR
HHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GLERQIATLCRKAAKTLITDTSKERIIITEHTIEDYLGKPYFRYGLMEQENQIGAATGLA
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCHHHHCCHHCCCCCCHHHCCE
YTSAGGDILSIEVSHYPGKGKLTLTGQLGDVMQESAQAAFSYVRSRTNHFHIEPDFYEKY
EECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEE
DIHIHVPAGATPKDGPSAGITIATALVSSLTGRAIKKEVGMTGEITLRGRVLPIGGLKEK
EEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHH
ALSAHRAGLTTIIIPDENEKDIENIPESVRNELTFIPVKHLDEVLEQALVEE
HHHHHHCCCEEEEECCCCCCHHHHCCHHHHHCEEEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961402; 8969504; 9384377 [H]