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The map label for this gene is hemD [H]

Identifier: 23099522

GI number: 23099522

Start: 2094475

End: 2095233

Strand: Reverse

Name: hemD [H]

Synonym: OB2067

Alternate gene names: 23099522

Gene position: 2095233-2094475 (Counterclockwise)

Preceding gene: 23099523

Following gene: 23099521

Centisome position: 57.71

GC content: 31.75

Gene sequence:

>759_bases
ATGAGTCACTCTCTTCAAGGAAAGAGTGTTTTGATTACTAGAGAAAAACAACAAGCAGAAGCTTTTGCTAAACAGATTGA
AAATTTTGGTGGTAAGCCACTGGTTGTCCCTCTTTTATCTATAGAATATAAAAGTGATATAAGTAACCCTATTTGGCTGC
ACTTAAAAAAATATGAATGGATTCTTTTCACTAGTTCAAATGGAGTTCACGGTTTTTTTCATTTTCTACATCAGTTAGAT
ATTGAATTTCCTTCTGATATAAAGGTTGGTATTGTTGGAACAAAAACGAAACTCGCATTAGATGAGTATGAATTGAAACC
AGATTTTATTCCCTCTATATTCGACGCAGAAACAATGGCAAAAGAATTTATAGAAAGCTATGATAGAGAACAACCTATAT
TAATTGTAAGAGGAAATCTCTCTAGAAATATTATTCCAAATGATTTTACTGAACATAATATTTCCTATGACACAATTGAA
GTATATGAAACGACGTATCGTTATGAAGCAAAGCGTGAATTAGAGGACACAATTAAGAATGTTGATTTTGTTACCTTAAC
TAGTCCTTCAACAGTGACGGCATTGATGAAGCTAGTGAAAGATATACCATTTTCATGTGATTATATATGTATTGGAACGA
CTACAGAAGCGAAAGCTGAAAAATTACAAATACCAAATCTTCATATTCCTAGTGAATTTACTACAGATGCAATGATAGAA
GTTATGATTGATTTGGCTTTAGGAAAGGATGTAACTTAA

Upstream 100 bases:

>100_bases
GCACAGAACCCACTGAAGTTGGGAAAGAAGCTGCGGAGTTATTAATAAGTCAAGGAGCAAAAGAAATCGTTGATCGGGTA
AAAGAGGAGATGGATCAGTA

Downstream 100 bases:

>100_bases
TATGGAACAACAGTTGACTTTTAAACGGCATCGTCGATTACGTGCATCTACATCTATGCGTTCATTAGTACGAGAAACGC
ATTTAAGACCTACTGATTTT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSHSLQGKSVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNPIWLHLKKYEWILFTSSNGVHGFFHFLHQLD
IEFPSDIKVGIVGTKTKLALDEYELKPDFIPSIFDAETMAKEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIE
VYETTYRYEAKRELEDTIKNVDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMIE
VMIDLALGKDVT

Sequences:

>Translated_252_residues
MSHSLQGKSVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNPIWLHLKKYEWILFTSSNGVHGFFHFLHQLD
IEFPSDIKVGIVGTKTKLALDEYELKPDFIPSIFDAETMAKEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIE
VYETTYRYEAKRELEDTIKNVDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMIE
VMIDLALGKDVT
>Mature_251_residues
SHSLQGKSVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNPIWLHLKKYEWILFTSSNGVHGFFHFLHQLDI
EFPSDIKVGIVGTKTKLALDEYELKPDFIPSIFDAETMAKEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEV
YETTYRYEAKRELEDTIKNVDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMIEV
MIDLALGKDVT

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 28744; Mature: 28613

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSLQGKSVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNPIWLHLKKYEW
CCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEEEEEEE
ILFTSSNGVHGFFHFLHQLDIEFPSDIKVGIVGTKTKLALDEYELKPDFIPSIFDAETMA
EEEECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEHHHCCCCCCCCCHHHHHHHH
KEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEVYETTYRYEAKRELEDTIKN
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
VDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMIE
CCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEECCCCCCCCCCCHHHHHH
VMIDLALGKDVT
HHHHHHCCCCCC
>Mature Secondary Structure 
SHSLQGKSVLITREKQQAEAFAKQIENFGGKPLVVPLLSIEYKSDISNPIWLHLKKYEW
CCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCEEEEEEEEEE
ILFTSSNGVHGFFHFLHQLDIEFPSDIKVGIVGTKTKLALDEYELKPDFIPSIFDAETMA
EEEECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCEEEEEHHHCCCCCCCCCHHHHHHHH
KEFIESYDREQPILIVRGNLSRNIIPNDFTEHNISYDTIEVYETTYRYEAKRELEDTIKN
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHC
VDFVTLTSPSTVTALMKLVKDIPFSCDYICIGTTTEAKAEKLQIPNLHIPSEFTTDAMIE
CCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEECCCCCCCCCCCHHHHHH
VMIDLALGKDVT
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]