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The map label for this gene is cysC

Identifier: 23099116

GI number: 23099116

Start: 1705039

End: 1705638

Strand: Direct

Name: cysC

Synonym: OB1661

Alternate gene names: 23099116

Gene position: 1705039-1705638 (Clockwise)

Preceding gene: 23099115

Following gene: 23099117

Centisome position: 46.96

GC content: 37.83

Gene sequence:

>600_bases
ATGAATAAATCTACGAATATCGTATGGCAAAAAACCAGTGTAAAGAAAGCAGATAGACAACATTTGAATAACCATAAAAG
TGCTGTATTGTGGTTTACTGGATTATCGGGGTCTGGTAAATCAACCTTATCTTCAGCATTGGAAAAAGAATTGTTTTCGC
TTGAGACACACACCTATCATCTTGATGGGGATAATGTTCGACATGGGTTGAATAAGAATCTTGGATTTAGTCCAGAAGAT
CGGGAAGAGAATATTCGTCGTATAGGAGAAGTTTCCAAACTGATGGTTGATGCGGGCTTAATTACACTGACAGCATTTAT
CTCCCCTTACCAAGAAGACAGGGATCATGTGAGAGCAACTCTTGCGCAAGATGAATTCATTGAGATTTACGTGAAGTGCA
GTCTGGATATGTGTGAAGCAAGAGATCCAAAGGGCTTGTACAAAAAAGCTCGATTGGGAGAAATTAATAATTTCACTGGA
ATTGATGCGCCGTATGAAGAACCACTTCATCCGGAAATTGTAATCGATACGGAAAACCAATCAATAGAGGAATCCGTTCA
AACCATCATTCATTATTTAAAAGATAAGCAATATATCTAA

Upstream 100 bases:

>100_bases
AGTTTATAGATTATGTAAAAATAGGGACACCATTAAGTCTGATAGTGATGGTATTGACTGTTAGCATTGTCAGTTACTGG
TGGTATTAGGAGGGGAAAAC

Downstream 100 bases:

>100_bases
GTCATGCGTTGACAATCGAGTTAGACGATCTACATTAATAAGAAACATTAAACCTTTATATGAAATATCATCATAACTAT
ACAAAATTATTTACTCCATA

Product: adenylylsulfate kinase

Products: NA

Alternate protein names: APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MNKSTNIVWQKTSVKKADRQHLNNHKSAVLWFTGLSGSGKSTLSSALEKELFSLETHTYHLDGDNVRHGLNKNLGFSPED
REENIRRIGEVSKLMVDAGLITLTAFISPYQEDRDHVRATLAQDEFIEIYVKCSLDMCEARDPKGLYKKARLGEINNFTG
IDAPYEEPLHPEIVIDTENQSIEESVQTIIHYLKDKQYI

Sequences:

>Translated_199_residues
MNKSTNIVWQKTSVKKADRQHLNNHKSAVLWFTGLSGSGKSTLSSALEKELFSLETHTYHLDGDNVRHGLNKNLGFSPED
REENIRRIGEVSKLMVDAGLITLTAFISPYQEDRDHVRATLAQDEFIEIYVKCSLDMCEARDPKGLYKKARLGEINNFTG
IDAPYEEPLHPEIVIDTENQSIEESVQTIIHYLKDKQYI
>Mature_199_residues
MNKSTNIVWQKTSVKKADRQHLNNHKSAVLWFTGLSGSGKSTLSSALEKELFSLETHTYHLDGDNVRHGLNKNLGFSPED
REENIRRIGEVSKLMVDAGLITLTAFISPYQEDRDHVRATLAQDEFIEIYVKCSLDMCEARDPKGLYKKARLGEINNFTG
IDAPYEEPLHPEIVIDTENQSIEESVQTIIHYLKDKQYI

Specific function: Catalyzes the synthesis of activated sulfate

COG id: COG0529

COG function: function code P; Adenylylsulfate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the APS kinase family

Homologues:

Organism=Homo sapiens, GI46094058, Length=205, Percent_Identity=47.8048780487805, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI62912492, Length=204, Percent_Identity=49.0196078431373, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI34447231, Length=204, Percent_Identity=49.0196078431373, Blast_Score=202, Evalue=2e-52,
Organism=Escherichia coli, GI1789107, Length=194, Percent_Identity=54.1237113402062, Blast_Score=214, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542422, Length=201, Percent_Identity=49.2537313432836, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322852, Length=198, Percent_Identity=50, Blast_Score=193, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24667032, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24667028, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24667036, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24667040, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI116007838, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24667044, Length=205, Percent_Identity=44.8780487804878, Blast_Score=184, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSC_OCEIH (Q8EQN3)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692582.1
- HSSP:   O43252
- ProteinModelPortal:   Q8EQN3
- SMR:   Q8EQN3
- GeneID:   1018157
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1661
- NMPDR:   fig|221109.1.peg.1664
- HOGENOM:   HBG309946
- OMA:   TVCESRD
- ProtClustDB:   PRK03846
- BioCyc:   OIHE221109:OB1661-MONOMER
- BRENDA:   2.7.1.25
- HAMAP:   MF_00065
- InterPro:   IPR002891
- TIGRFAMs:   TIGR00455

Pfam domain/function: PF01583 APS_kinase

EC number: =2.7.1.25

Molecular weight: Translated: 22693; Mature: 22693

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSTNIVWQKTSVKKADRQHLNNHKSAVLWFTGLSGSGKSTLSSALEKELFSLETHTYH
CCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEE
LDGDNVRHGLNKNLGFSPEDREENIRRIGEVSKLMVDAGLITLTAFISPYQEDRDHVRAT
CCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAQDEFIEIYVKCSLDMCEARDPKGLYKKARLGEINNFTGIDAPYEEPLHPEIVIDTENQ
HCCCCEEEEEEEECCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCC
SIEESVQTIIHYLKDKQYI
CHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKSTNIVWQKTSVKKADRQHLNNHKSAVLWFTGLSGSGKSTLSSALEKELFSLETHTYH
CCCCCCEEEECCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCEEEE
LDGDNVRHGLNKNLGFSPEDREENIRRIGEVSKLMVDAGLITLTAFISPYQEDRDHVRAT
CCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LAQDEFIEIYVKCSLDMCEARDPKGLYKKARLGEINNFTGIDAPYEEPLHPEIVIDTENQ
HCCCCEEEEEEEECCHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCC
SIEESVQTIIHYLKDKQYI
CHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376