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The map label for this gene is mraY

Identifier: 23098923

GI number: 23098923

Start: 1507709

End: 1508689

Strand: Direct

Name: mraY

Synonym: OB1468

Alternate gene names: 23098923

Gene position: 1507709-1508689 (Clockwise)

Preceding gene: 23098922

Following gene: 23098924

Centisome position: 41.53

GC content: 34.45

Gene sequence:

>981_bases
GTGGACTTAACTGGATTATTAATAACAATAGTTGTAGCATTTCTCATTACCGTTCTTCTATCTCCTATTTTTATACCATT
TTTAAGAAGATTAAATTTTGGACAAAGCATTAGAGAAGAAGGACCACAGTCACATCAAAAAAAGACAGGAACACCTACGA
TGGGTGGGCTGATGATTATATTTAGTATAATCATCACGTCACTTATTATGGCAAGCAGAACGGATGAAGGTATTAATTAT
CAGGTGTGGTTATTGATTTTTGTATTATTTGGATATGGATTATTAGGCTTTTTAGATGATTTTATAAAAGTTGCAATGAA
AAGAAATCTTGGACTAACTTCTAAACAAAAATTATTCGGCCAAATAATAATTGCACTCGTCTTTTATTTTATTTTAAGAA
ATCAAGGGTTTTCGACAGTCATTTATGTGCCGGGGACTGAATTACAATTTGATATTGGTTGGTTTTATGCCGTATTAGTT
ATATTTATGATGGTTGGTGCTTCCAATGCAGTCAACTTAACGGATGGATTAGACGGGCTATTAGCAGGAACCGCAGCCAT
AGCATTTGGAGCATTTGCTATCATTGCTTGGTATGGAATACCTGATCATGTAGTAGCCGTGTTCTCCTTAGCAGTAGTAG
GTGCTTTACTTGGCTTTTTAGTTTTCAATGCACATCCTGCAAAAGTATTTATGGGTGATACAGGCTCATTAGCTCTTGGT
GGAGCAATTGCTGCAATATCTATTTTATTGAAATTAGAAATTTTACTGATTATTATAGGCGGAGTTTTTGTAATAGAAAC
ATTGTCTGTAATTATTCAAGTGATTTCATTTAAAACAACTGGTAAACGTGTATTCAAAATGAGTCCATTACATCACCACT
ATGAACTATTAGGCTGGTCAGAGTGGCGTGTAGTCACTACTTTTTGGTTGGTAGGTTTATTGTTTGCTATGCTTGGTGTT
TATATTGAGGTGGGAATGTAA

Upstream 100 bases:

>100_bases
TCTAGAGGAATGAAGTTTGAAATGTTTATTAAAGAATTACAGCAGTAATCGAACATCTAGTTACTTAGTTGGACGGTTTA
ATAAGTGAGGAGGAAATGAA

Downstream 100 bases:

>100_bases
TGAATGTACTTACAAATTTTCCTTATCAGCACGTACTTGTATTAGGATTAGCTAAAAGTGGCACAGCAGCGGCAAACGTT
TTATTGCAAAATCATATACA

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDLTGLLITIVVAFLITVLLSPIFIPFLRRLNFGQSIREEGPQSHQKKTGTPTMGGLMIIFSIIITSLIMASRTDEGINY
QVWLLIFVLFGYGLLGFLDDFIKVAMKRNLGLTSKQKLFGQIIIALVFYFILRNQGFSTVIYVPGTELQFDIGWFYAVLV
IFMMVGASNAVNLTDGLDGLLAGTAAIAFGAFAIIAWYGIPDHVVAVFSLAVVGALLGFLVFNAHPAKVFMGDTGSLALG
GAIAAISILLKLEILLIIIGGVFVIETLSVIIQVISFKTTGKRVFKMSPLHHHYELLGWSEWRVVTTFWLVGLLFAMLGV
YIEVGM

Sequences:

>Translated_326_residues
MDLTGLLITIVVAFLITVLLSPIFIPFLRRLNFGQSIREEGPQSHQKKTGTPTMGGLMIIFSIIITSLIMASRTDEGINY
QVWLLIFVLFGYGLLGFLDDFIKVAMKRNLGLTSKQKLFGQIIIALVFYFILRNQGFSTVIYVPGTELQFDIGWFYAVLV
IFMMVGASNAVNLTDGLDGLLAGTAAIAFGAFAIIAWYGIPDHVVAVFSLAVVGALLGFLVFNAHPAKVFMGDTGSLALG
GAIAAISILLKLEILLIIIGGVFVIETLSVIIQVISFKTTGKRVFKMSPLHHHYELLGWSEWRVVTTFWLVGLLFAMLGV
YIEVGM
>Mature_326_residues
MDLTGLLITIVVAFLITVLLSPIFIPFLRRLNFGQSIREEGPQSHQKKTGTPTMGGLMIIFSIIITSLIMASRTDEGINY
QVWLLIFVLFGYGLLGFLDDFIKVAMKRNLGLTSKQKLFGQIIIALVFYFILRNQGFSTVIYVPGTELQFDIGWFYAVLV
IFMMVGASNAVNLTDGLDGLLAGTAAIAFGAFAIIAWYGIPDHVVAVFSLAVVGALLGFLVFNAHPAKVFMGDTGSLALG
GAIAAISILLKLEILLIIIGGVFVIETLSVIIQVISFKTTGKRVFKMSPLHHHYELLGWSEWRVVTTFWLVGLLFAMLGV
YIEVGM

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=336, Percent_Identity=45.2380952380952, Blast_Score=255, Evalue=3e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_OCEIH (Q8ER51)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692389.1
- GeneID:   1017715
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1468
- NMPDR:   fig|221109.1.peg.1470
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BioCyc:   OIHE221109:OB1468-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 35706; Mature: 35706

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd6133c4)-; HASH(0xe7536a4)-; HASH(0xe86a320)-; HASH(0xe3850dc)-; HASH(0xea2f978)-; HASH(0xe987c24)-; HASH(0xed43490)-; HASH(0xdcf5388)-; HASH(0xed2fecc)-; HASH(0xebcec70)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTGLLITIVVAFLITVLLSPIFIPFLRRLNFGQSIREEGPQSHQKKTGTPTMGGLMII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCCCHHHHHHH
FSIIITSLIMASRTDEGINYQVWLLIFVLFGYGLLGFLDDFIKVAMKRNLGLTSKQKLFG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QIIIALVFYFILRNQGFSTVIYVPGTELQFDIGWFYAVLVIFMMVGASNAVNLTDGLDGL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAGTAAIAFGAFAIIAWYGIPDHVVAVFSLAVVGALLGFLVFNAHPAKVFMGDTGSLALG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
GAIAAISILLKLEILLIIIGGVFVIETLSVIIQVISFKTTGKRVFKMSPLHHHYELLGWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHHHHHHHCCC
EWRVVTTFWLVGLLFAMLGVYIEVGM
HHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MDLTGLLITIVVAFLITVLLSPIFIPFLRRLNFGQSIREEGPQSHQKKTGTPTMGGLMII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCCCHHHHHHH
FSIIITSLIMASRTDEGINYQVWLLIFVLFGYGLLGFLDDFIKVAMKRNLGLTSKQKLFG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QIIIALVFYFILRNQGFSTVIYVPGTELQFDIGWFYAVLVIFMMVGASNAVNLTDGLDGL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LAGTAAIAFGAFAIIAWYGIPDHVVAVFSLAVVGALLGFLVFNAHPAKVFMGDTGSLALG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
GAIAAISILLKLEILLIIIGGVFVIETLSVIIQVISFKTTGKRVFKMSPLHHHYELLGWS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCHHHHHHHHCCC
EWRVVTTFWLVGLLFAMLGVYIEVGM
HHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376