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The map label for this gene is ygcA [C]

Identifier: 23098223

GI number: 23098223

Start: 820450

End: 821829

Strand: Direct

Name: ygcA [C]

Synonym: OB0768

Alternate gene names: 23098223

Gene position: 820450-821829 (Clockwise)

Preceding gene: 23098222

Following gene: 23098225

Centisome position: 22.6

GC content: 37.83

Gene sequence:

>1380_bases
ATGGCAAAAACAAAGCCTCCAGTAAATAAAAATGAAATATATACACTAACCTTCGAGGATCTAACACATGAAGGGAACGG
TGTTGCTAAGATAGAAGGATACCCATTGTTTGTACCAGAAGTTTTACCTGATGAACAAGCAAAGGTAAAAGTGGTAAAGG
TCAACAAGAACTTTGGATTTGGAAAATTACTTGAACTAACGAAAACAAGTTCCCATCGTGTAGAACCTACATGCCATGTA
CATTGCGGTGGATGCCAATTACAACATATGAGTTATGATTTACAGCTTCAAATGAAGCAAGGTCAGGTGCATAATGTGAT
GAAGAAAGTAGCTCACCTGGATCAAGTACCAGTACATCCGATATTAGGGATGGAAGAGCCATCGCACTACCGTAATAAAG
TACAAATTCCTGTAGGGGAGAAGAATGGAGAAGTCATTGTGGGCTTTTATCAAAAACGAAGCCATCGAATTCTTCAAAAT
CAAGATACCTGTCATATCCAAGATGAAGCAATCAATGAGGTATTACCTTTCACTCGACAACTGATGAATAAATATGGCAT
CCAAGCTTATGATGAAAAATCTCACCGAGGTCAACTCCGCCATATTATGGTTCGTGTCGGTCACTATACGAAAGATATTA
TGATCGTATTTGTGACGAAAACGTCCAAGTTCCCGGAAAAGGATCGAATTATTAAGGAATTAACAGAACAGTTCCCTCAA
GTGAAATCCATTGTTCAAAATGTGAATGATCAACGAACGAATGTGGTACTTGGTAAAAAGACAAAGGTTCTTTGGGGAGA
GAATTATATATATGATAAAATTGGGGATCTTACATTTGCGATTTCCCCTAAATCGTTTTTCCAAGTAAATCCTGTTCAAA
CAAAGGTCTTGTATGATAAAGCATTAGAATATGCCAATATTGATAAGGACGATGTAGTAATTGACGCTTATTGCGGTATC
GGTAGCATTTCCTTATTCTTAGCTCAAAAAGCAAAGAAAGTATATGGCATTGAAGTCGTTCCAGAAGCTATAGAAGATGC
GAAAATGAATGCAGAGATAAATGGGATGAACAACGTGGAATTTTCTGTTGGACAAGCAGAAAAAGTGATGCCGAAGTGGA
AAGAACAAGGATTAGATCCGGATGTCATTGTAGTCGATCCGCCTCGAAAAGGATGCGATGTTGATTTCTTAGAAGCAATG
ATAGCAATGAAACCTAAACGTATTGTCTATGTTTCTTGTAACCCTTCCACATTAGCTCGCGATCTGCGTATATTAGAAGA
TGGTGGTTTTGAAACAAAACAAGTACAACCTGTTGATATGTTTCCGAGCACCAATCATGTTGAATGTGTAGCGGAATTAA
CTCTGAAATTGTCTAACTAA

Upstream 100 bases:

>100_bases
ATGTTTAGAAGGATAAGAAAGATGGGATTCTATTCTTGAGACGGCGCTTATGGTAGAATAATTATTTAAGACGAATATCG
TAATAAAAAGGAAGAGTGTT

Downstream 100 bases:

>100_bases
AATAAACTCTTGCTAAATCGACCCTGATTCCGTAAAAATAAACATTTGCGAAATCGGGGTTTTTTAATAATAACCAGGTG
TTTCATTAAATAAAAAACTG

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MAKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGFGKLLELTKTSSHRVEPTCHV
HCGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHPILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQN
QDTCHIQDEAINEVLPFTRQLMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQ
VKSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDKALEYANIDKDDVVIDAYCGI
GSISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVEFSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAM
IAMKPKRIVYVSCNPSTLARDLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN

Sequences:

>Translated_459_residues
MAKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGFGKLLELTKTSSHRVEPTCHV
HCGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHPILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQN
QDTCHIQDEAINEVLPFTRQLMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQ
VKSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDKALEYANIDKDDVVIDAYCGI
GSISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVEFSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAM
IAMKPKRIVYVSCNPSTLARDLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN
>Mature_458_residues
AKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGFGKLLELTKTSSHRVEPTCHVH
CGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHPILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQNQ
DTCHIQDEAINEVLPFTRQLMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQV
KSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDKALEYANIDKDDVVIDAYCGIG
SISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVEFSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAMI
AMKPKRIVYVSCNPSTLARDLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=411, Percent_Identity=29.4403892944039, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI51173878, Length=411, Percent_Identity=29.4403892944039, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI269784680, Length=418, Percent_Identity=27.2727272727273, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI269784676, Length=418, Percent_Identity=27.2727272727273, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI20149688, Length=418, Percent_Identity=27.2727272727273, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI269784678, Length=211, Percent_Identity=36.0189573459716, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1789148, Length=448, Percent_Identity=30.8035714285714, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI1787083, Length=380, Percent_Identity=27.3684210526316, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790403, Length=245, Percent_Identity=30.2040816326531, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71997438, Length=168, Percent_Identity=34.5238095238095, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=438, Percent_Identity=27.3972602739726, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666579, Length=414, Percent_Identity=30.9178743961353, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y768_OCEIH (Q8ES75)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691689.1
- ProteinModelPortal:   Q8ES75
- SMR:   Q8ES75
- GeneID:   1016302
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0768
- NMPDR:   fig|221109.1.peg.776
- HOGENOM:   HBG690163
- OMA:   RKGCDEA
- BioCyc:   OIHE221109:OB0768-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 52063; Mature: 51932

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 413-413 BINDING 288-288 BINDING 317-317 BINDING 338-338 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGF
CCCCCCCCCCCEEEEEEEHHCCCCCCCEEEECCCEEECCCCCCCCCCEEEEEEEECCCCC
GKLLELTKTSSHRVEPTCHVHCGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHP
HHHHHHHCCCCCCCCCEEEEEECCEEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCCCC
ILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQNQDTCHIQDEAINEVLPFTRQ
CCCCCCCCHHCCEEEEEECCCCCCEEEEEECCCCCHHHCCCCCEEECHHHHHHHHHHHHH
LMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQ
HHHHHCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
VKSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDK
HHHHHHCCCCCCCEEEEECCEEEEECCCEEEECCCCEEEEECCCHHEEECCCHHHHHHHH
ALEYANIDKDDVVIDAYCGIGSISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVE
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHCCCCCEEECCCCCEE
FSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAMIAMKPKRIVYVSCNPSTLAR
EECCCHHHHCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHH
DLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN
HHHEEECCCCCCCEECEEECCCCCCHHHEEEEEEEEECC
>Mature Secondary Structure 
AKTKPPVNKNEIYTLTFEDLTHEGNGVAKIEGYPLFVPEVLPDEQAKVKVVKVNKNFGF
CCCCCCCCCCEEEEEEEHHCCCCCCCEEEECCCEEECCCCCCCCCCEEEEEEEECCCCC
GKLLELTKTSSHRVEPTCHVHCGGCQLQHMSYDLQLQMKQGQVHNVMKKVAHLDQVPVHP
HHHHHHHCCCCCCCCCEEEEEECCEEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCCCC
ILGMEEPSHYRNKVQIPVGEKNGEVIVGFYQKRSHRILQNQDTCHIQDEAINEVLPFTRQ
CCCCCCCCHHCCEEEEEECCCCCCEEEEEECCCCCHHHCCCCCEEECHHHHHHHHHHHHH
LMNKYGIQAYDEKSHRGQLRHIMVRVGHYTKDIMIVFVTKTSKFPEKDRIIKELTEQFPQ
HHHHHCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
VKSIVQNVNDQRTNVVLGKKTKVLWGENYIYDKIGDLTFAISPKSFFQVNPVQTKVLYDK
HHHHHHCCCCCCCEEEEECCEEEEECCCEEEECCCCEEEEECCCHHEEECCCHHHHHHHH
ALEYANIDKDDVVIDAYCGIGSISLFLAQKAKKVYGIEVVPEAIEDAKMNAEINGMNNVE
HHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECHHHHHCCCCCEEECCCCCEE
FSVGQAEKVMPKWKEQGLDPDVIVVDPPRKGCDVDFLEAMIAMKPKRIVYVSCNPSTLAR
EECCCHHHHCHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHH
DLRILEDGGFETKQVQPVDMFPSTNHVECVAELTLKLSN
HHHEEECCCCCCCEECEEECCCCCCHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376