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The map label for this gene is purM

Identifier: 23098202

GI number: 23098202

Start: 795231

End: 796250

Strand: Direct

Name: purM

Synonym: OB0747

Alternate gene names: 23098202

Gene position: 795231-796250 (Clockwise)

Preceding gene: 23098201

Following gene: 23098203

Centisome position: 21.9

GC content: 39.12

Gene sequence:

>1020_bases
ATGTCAGAAGTCTATAAACAAGCAGGAGTAGATGTTGAAAAAGGGTATGAAGCTGTAGAACGGCTAAAAAAACATGTCGC
TCGTACACATCGTCCAGAGGTATTAGGGGGCATAGGTGCTTTTGCAGGAGCGTTTGATCTATCGTCGTTACAATATAAAG
AACCCGTTCTCCTTTCTGGTACAGATGGGGTTGGAACAAAATTAAAACTAGCTATTGACTTAGATAAGCATGACACGGTT
GGGATTGATTTAGTGGCAATGTGTGTCAATGATATCATCGCCCAAGGTGGAGATCCTCTGTTCTTTTTAGATTATATCGC
ATGTGGTGAAAATGATCCTTCTAGGATAGAAGCAATTGTATCTGGTATTGCCGAAGGATGTGAACAAGCAGGAGCTGCGT
TAATAGGTGGAGAGACTGCTGAAATGCCTGGTATGTATGATCCTGATGAATATGATTTAGCAGGATTTGTCGTTGGAATT
GTGGAAAAATCAGCGATGATCACAGGTAAAGATATCAAATCTGGTGATGTAGTAATTGGACTTTCATCCAGCGGGATTCA
TTCAAATGGCTATTCACTCGTCCGTAAATTAATAGCGGATGTCGATTTAAATCAAACATACCCTGGCTTAAGTCAAACAG
TAAAAGATGCAGTAATGGCACCAACTAAAATTTATGCAAAATCGATTCAAGCATTAAAAAAAGAAGTGAATTTAAAGGGA
ATATCGCATATTACTGGTGGCGGATTTGATGAAAATATTCCGCGTATGTTACCAGATGGATTAGGTGTTCTAATTGAGAC
AAATAGCTGGGATATACCAGAGGTTTTTCACTTCCTAGAAGAAAAAGGGAATATTGATAACAGAGAAATGTATGGCGTGT
TCAACATGGGAATTGGAATGGCAGTGGTTGTGGCTGAAGAAGATGTTTCTATCGCATTACAGTTACTCGAAAAAGTAGAT
GAACAAGCATATGTGATTGGTAAGGTAACAGAGGAGGAAGGAGTGCACTTTACATTATGA

Upstream 100 bases:

>100_bases
TGTATGGCTTGTATGACTGGCAAATACCCAGTAAAACAAGACGGTGAATTGGAAATTCATTATACAAGTTGTTAAAAGAA
GTTTACGTGGAGGGATTACC

Downstream 100 bases:

>100_bases
CTATAAAAGCAGCTGTTTTTGCTTCAGGTGCGGGTAGTAATTTTGAGGCAATAATGGAAGCAAACGATTTGAAGTGTAAG
ATTTCTCTTCTCGTATGCGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSGTDGVGTKLKLAIDLDKHDTV
GIDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIVSGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGI
VEKSAMITGKDIKSGDVVIGLSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKG
ISHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGMAVVVAEEDVSIALQLLEKVD
EQAYVIGKVTEEEGVHFTL

Sequences:

>Translated_339_residues
MSEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSGTDGVGTKLKLAIDLDKHDTV
GIDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIVSGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGI
VEKSAMITGKDIKSGDVVIGLSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKG
ISHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGMAVVVAEEDVSIALQLLEKVD
EQAYVIGKVTEEEGVHFTL
>Mature_338_residues
SEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSGTDGVGTKLKLAIDLDKHDTVG
IDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIVSGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGIV
EKSAMITGKDIKSGDVVIGLSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKGI
SHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGMAVVVAEEDVSIALQLLEKVDE
QAYVIGKVTEEEGVHFTL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=48.6486486486487, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=48.6486486486487, Blast_Score=328, Evalue=6e-90,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=48.6486486486487, Blast_Score=328, Evalue=6e-90,
Organism=Escherichia coli, GI1788845, Length=324, Percent_Identity=53.7037037037037, Blast_Score=351, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=333, Percent_Identity=38.1381381381381, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=42.9850746268657, Blast_Score=275, Evalue=8e-75,
Organism=Drosophila melanogaster, GI24582400, Length=288, Percent_Identity=42.3611111111111, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_OCEIH (Q8ES94)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691668.1
- ProteinModelPortal:   Q8ES94
- SMR:   Q8ES94
- GeneID:   1016271
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0747
- NMPDR:   fig|221109.1.peg.755
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   OIHE221109:OB0747-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36327; Mature: 36196

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSG
CCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEC
TDGVGTKLKLAIDLDKHDTVGIDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
SGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGIVEKSAMITGKDIKSGDVVIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCEEEE
LSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKG
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
ISHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGM
CCCCCCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCE
AVVVAEEDVSIALQLLEKVDEQAYVIGKVTEEEGVHFTL
EEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCEECC
>Mature Secondary Structure 
SEVYKQAGVDVEKGYEAVERLKKHVARTHRPEVLGGIGAFAGAFDLSSLQYKEPVLLSG
CHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEC
TDGVGTKLKLAIDLDKHDTVGIDLVAMCVNDIIAQGGDPLFFLDYIACGENDPSRIEAIV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
SGIAEGCEQAGAALIGGETAEMPGMYDPDEYDLAGFVVGIVEKSAMITGKDIKSGDVVIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEECCCCCCCCEEEE
LSSSGIHSNGYSLVRKLIADVDLNQTYPGLSQTVKDAVMAPTKIYAKSIQALKKEVNLKG
ECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
ISHITGGGFDENIPRMLPDGLGVLIETNSWDIPEVFHFLEEKGNIDNREMYGVFNMGIGM
CCCCCCCCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCE
AVVVAEEDVSIALQLLEKVDEQAYVIGKVTEEEGVHFTL
EEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376