Click here to switch to the map view.

The map label for this gene is purL

Identifier: 23098200

GI number: 23098200

Start: 791595

End: 793823

Strand: Direct

Name: purL

Synonym: OB0745

Alternate gene names: 23098200

Gene position: 791595-793823 (Clockwise)

Preceding gene: 23098199

Following gene: 23098201

Centisome position: 21.8

GC content: 40.2

Gene sequence:

>2229_bases
ATGCAATTAACGCATGATATACAACCAGAGAAAATTGAGAAGGACCGTCTTTACCTAGATATGGGATTAAGTGATGAAGA
GTTTCAACGAATTAAACAAATACTCGGACGTCATCCGAATTTTACAGAGACAGGTATTTTTTCCGTAATGTGGTCAGAGC
ATTGTAGCTATAAAACGTCAAAACCACTGTTGAAAAAGTTTCCTACAGATGGACCACATGTCTTACAAGGACCTGGTGAA
GGTGCTGGCGTAATTGATATTGGTGACGAGCAAGCAGTCGTATTTAAAATCGAAAGTCATAATCATCCATCAGCAGTTGA
ACCCTACCAAGGAGCTGCTACTGGAGTAGGTGGAATCATTCGTGATGTATTTTCAATGGGGGCACGACCAATTGCTTCGC
TTAATTCATTACGATTTGGACCATTAACGAATAATCGTACGAAGTATCTCTTTTCTGAAGTAGTCGCTGGAATAGCTGGA
TATGGTAACTGTGTCGGTGTTCCGACAGTTGGCGGAGAAGTACAATTCGATGAAAGTTATGAAGATAATCCTCTTGTGAA
TGCGATGTGTGTCGGATTAATTAATCATAAAGATGTGCAAAAAGGGATAGCAGCGGGGATTGGAAATACCATTCTTTATG
CAGGACCACCAACTGGTCGTGATGGAATCCATGGCGCTACGTTTGCCTCTGATGATCTAGCGGAAGATTCGAATAAAGAC
AGACCTGCTGTCCAGGTCGGAGATCCATTTATGGAAAAATTATTAATCGAAGCTTGTTTAGAGGTAATACAATCGGATGC
ATTAGTCGGCATTCAAGATATGGGTGCGGCAGGACTGACATCCTCTGCCAGTGAAATGGCAAGTAAAGCTGGAACTGGTT
TAGAGATGAATCTTGATCTTGTTCCCCAACGTGAACAAGGAATGACAGCATATGAAATGATGCTTTCTGAGTCTCAAGAG
CGTATGTTGCTTTGTGTGCAAGCAGGCCGTGAACAAGAAATTATCGATATATTCGAAAAATACGGACTTAAATCTGTACC
AGTAGGAAAAGTAATTGAAGAAAAAGTATTCCGTATTAAGCACCTTGATGAAGTGGTCGCTGACATCCCTGTTGATTCAT
TAGCAGACGATGCTCCTGTCTATAATATGCCATCCAAGGAGGCGGCTTACTACAGAGCTTTTCAACAAATGGATATAGCA
ACACCGGCTATTGAAGATTATGCAAATACGTTAAAACAACTATTACAACAACCGACAATCGCGAACAAAGAGTGGGTTTA
TGATCAATATGATTCCATGGTGCAAACCAATACCGTCGTTACCCCTGGTTCAGATGCTGCAGTTGTTCGGATTAAAGGAA
CGGAAAAAGCACTTGCAATGACAACAGATTGTAATTCGAGATACATCTATCTAGATCCAGAAACAGGTGGAAAAATCGCA
GTAGCAGAAGCAGCGAGAAACATCGTGTGCTCAGGAGCAAAACCACTAGGATTAACAGATGGATTAAACTTTGGTAATCC
GACGAATCCAGAGATCTTTTGGCAAATGGAGAAGAGTGTAGAAGGAATGAGTGCTGCATGTGATGCACTGCATACGCCGG
TAATTAGTGGAAATGTTTCTTTATACAATCAATCAAAAGGAAAATCTATTTATCCAACACCAATTGTAGGAATGGTTGGT
TTGCATGAATCGACGCAACATATTACACCTAGTTATTTTCAAGAGAAAGAGGATGTAATTTATTGTATTGGTGAAGCAAA
AGCAGAATTCGGAGGTTCAGAATTACAACATTTATACTCTGGAAAATATGAAGGAAAAGCACCACATATTGATTTAGATG
TGGAGGCAGAACGTCAAGAAAAACTACTTTCAGCTATTAAAGAAGGAATTATTTCGTCTGCACATGACATATCTGAAGGT
GGTCTAGCGATTGCCTTAGCTGAGTCTTTATTCAATGGTCAAGGCCTTGGAGCGGAAATTAATGTAGTAGGAGATGCAAC
CGTAGAACTATTTAGTGAATCTCAATCACGGTTCCTTGTTTCCGTCAACAAGAAACATGCGAATGCATTTGAGTCTCATT
TTCCAGAAGCAGCTAAGTTAGGCAAGGTTACTGATCAAGGGCAACTAACTATTTCTATTAGCGATAAAACAATTATTCAC
GAACGTGTCGAAGAATTAGAGAATCTTTGGAAGGGAGCTATTCCATGCTTGCTGAAATCAAAGGCATAA

Upstream 100 bases:

>100_bases
GGGATGATGCCTCACCCAGAACGAGCTGTAGAAGAACTACTTGGCAGTGACGATGGATTGAAACTGTTTAAATCAATGAT
CGCAAATTGGAGGGACAGCT

Downstream 100 bases:

>100_bases
ATGAAGAATGTGGTGTTTTTGGCATCTGGGGTCACGAAAAAGCAGCTGAATTAACTTATTATGGCTTACATTCCATGCAA
CATCGAGGACAAGAAGGTGC

Product: phosphoribosylformylglycinamidine synthase component II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTSKPLLKKFPTDGPHVLQGPGE
GAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAG
YGNCVGVPTVGGEVQFDESYEDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKD
RPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDLVPQREQGMTAYEMMLSESQE
RMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIKHLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIA
TPAIEDYANTLKQLLQQPTIANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIA
VAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVSLYNQSKGKSIYPTPIVGMVG
LHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYSGKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEG
GLAIALAESLFNGQGLGAEINVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIH
ERVEELENLWKGAIPCLLKSKA

Sequences:

>Translated_742_residues
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTSKPLLKKFPTDGPHVLQGPGE
GAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAG
YGNCVGVPTVGGEVQFDESYEDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKD
RPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDLVPQREQGMTAYEMMLSESQE
RMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIKHLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIA
TPAIEDYANTLKQLLQQPTIANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIA
VAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVSLYNQSKGKSIYPTPIVGMVG
LHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYSGKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEG
GLAIALAESLFNGQGLGAEINVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIH
ERVEELENLWKGAIPCLLKSKA
>Mature_742_residues
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTSKPLLKKFPTDGPHVLQGPGE
GAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGIIRDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAG
YGNCVGVPTVGGEVQFDESYEDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKD
RPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDLVPQREQGMTAYEMMLSESQE
RMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIKHLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIA
TPAIEDYANTLKQLLQQPTIANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIA
VAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVSLYNQSKGKSIYPTPIVGMVG
LHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYSGKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEG
GLAIALAESLFNGQGLGAEINVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIH
ERVEELENLWKGAIPCLLKSKA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=827, Percent_Identity=24.546553808948, Blast_Score=149, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17553022, Length=648, Percent_Identity=24.2283950617284, Blast_Score=102, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321498, Length=833, Percent_Identity=22.6890756302521, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_OCEIH (Q8ES96)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691666.1
- ProteinModelPortal:   Q8ES96
- SMR:   Q8ES96
- GeneID:   1016269
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0745
- NMPDR:   fig|221109.1.peg.753
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- BioCyc:   OIHE221109:OB0745-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80445; Mature: 80445

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTS
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KPLLKKFPTDGPHVLQGPGEGAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAGYGNCVGVPTVGGEVQFDESY
HHHHHCCCCCHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKD
CCCCCHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCC
RPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDL
CCEEEECCHHHHHHHHHHHHHHHHCCCEECHHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
VPQREQGMTAYEMMLSESQERMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIK
CCCHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIATPAIEDYANTLKQLLQQPTI
HHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
ANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIA
CCCCCHHHHHHHHHHCCEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEEE
VAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVS
HHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEECCEE
LYNQSKGKSIYPTPIVGMVGLHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYS
EEECCCCCEECCCCCHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCHHHCCHHHHHHHHC
GKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEGGLAIALAESLFNGQGLGAEI
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCEEE
NVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIH
EEECCHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCHHHHH
ERVEELENLWKGAIPCLLKSKA
HHHHHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure
MQLTHDIQPEKIEKDRLYLDMGLSDEEFQRIKQILGRHPNFTETGIFSVMWSEHCSYKTS
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
KPLLKKFPTDGPHVLQGPGEGAGVIDIGDEQAVVFKIESHNHPSAVEPYQGAATGVGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPIASLNSLRFGPLTNNRTKYLFSEVVAGIAGYGNCVGVPTVGGEVQFDESY
HHHHHCCCCCHHHHCCEECCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EDNPLVNAMCVGLINHKDVQKGIAAGIGNTILYAGPPTGRDGIHGATFASDDLAEDSNKD
CCCCCHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCC
RPAVQVGDPFMEKLLIEACLEVIQSDALVGIQDMGAAGLTSSASEMASKAGTGLEMNLDL
CCEEEECCHHHHHHHHHHHHHHHHCCCEECHHHCCCCCCCCCHHHHHHHCCCCEEEEEEE
VPQREQGMTAYEMMLSESQERMLLCVQAGREQEIIDIFEKYGLKSVPVGKVIEEKVFRIK
CCCHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
HLDEVVADIPVDSLADDAPVYNMPSKEAAYYRAFQQMDIATPAIEDYANTLKQLLQQPTI
HHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
ANKEWVYDQYDSMVQTNTVVTPGSDAAVVRIKGTEKALAMTTDCNSRYIYLDPETGGKIA
CCCCCHHHHHHHHHHCCEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEEE
VAEAARNIVCSGAKPLGLTDGLNFGNPTNPEIFWQMEKSVEGMSAACDALHTPVISGNVS
HHHHHHHHEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEECCEE
LYNQSKGKSIYPTPIVGMVGLHESTQHITPSYFQEKEDVIYCIGEAKAEFGGSELQHLYS
EEECCCCCEECCCCCHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCHHHCCHHHHHHHHC
GKYEGKAPHIDLDVEAERQEKLLSAIKEGIISSAHDISEGGLAIALAESLFNGQGLGAEI
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCEEE
NVVGDATVELFSESQSRFLVSVNKKHANAFESHFPEAAKLGKVTDQGQLTISISDKTIIH
EEECCHHHHHHHCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCEEEEEECCHHHHH
ERVEELENLWKGAIPCLLKSKA
HHHHHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376