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The map label for this gene is purQ

Identifier: 23098199

GI number: 23098199

Start: 790925

End: 791611

Strand: Direct

Name: purQ

Synonym: OB0744

Alternate gene names: 23098199

Gene position: 790925-791611 (Clockwise)

Preceding gene: 23098198

Following gene: 23098200

Centisome position: 21.79

GC content: 39.3

Gene sequence:

>687_bases
GTGAAATTTGCTGTCATCGTGTTTCCAGGTTCAAATTGTGATCGAGATATGTACCACGCAGTAAAGGAAGTAGCAGGTGC
TGAAGCAGAACTTGTTTGGTATACAGAAACAGATAAATTAGAAGGTGTAGACGGAATTTTACTCCCAGGTGGCTTTTCCT
ATGGTGATTACTTACGTTCAGGATCAATGGCTTCGACTTCAGATGTTATGCATAAAATTCGTGAGCATGCAGCGAAAGGA
AAGCCGGTTTTAGGAGTGTGTAATGGATTCCAAATCTTAACGGAATCTGGACTTCTACCTGGAGCATTGATGAGAAATAA
ACATCTGTCATTCATGTGTCATCAAGAAGAACTAGTGGTGGAGGATAATCAAACGTTTTTCACTTCTTTATATGAAAAGA
AGGAAGTGGTTCGTTTTCCGATTGCACACGGTGAAGGAAGTTATTTCTGTGATGAGGCAACGTTGAAAGAGTTACAAGCA
AATAATCAAATCGTATTTACATATAAAAACAATCCAAATGGATCGATTGAAAATATCGCAGGCATTCGAAATAAACAAGG
AAATGTACTTGGGATGATGCCTCACCCAGAACGAGCTGTAGAAGAACTACTTGGCAGTGACGATGGATTGAAACTGTTTA
AATCAATGATCGCAAATTGGAGGGACAGCTATGCAATTAACGCATGA

Upstream 100 bases:

>100_bases
GCCTAACATTGAAGAACGCATCACGGAGATGTGTGACCGTCTTTTAGCGAACCCAGTTATTGAGAATTATCAATTTGATT
TAGAGGGGGTTAAGTAAACC

Downstream 100 bases:

>100_bases
TATACAACCAGAGAAAATTGAGAAGGACCGTCTTTACCTAGATATGGGATTAAGTGATGAAGAGTTTCAACGAATTAAAC
AAATACTCGGACGTCATCCG

Product: phosphoribosylformylglycinamidine synthase component I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKFAVIVFPGSNCDRDMYHAVKEVAGAEAELVWYTETDKLEGVDGILLPGGFSYGDYLRSGSMASTSDVMHKIREHAAKG
KPVLGVCNGFQILTESGLLPGALMRNKHLSFMCHQEELVVEDNQTFFTSLYEKKEVVRFPIAHGEGSYFCDEATLKELQA
NNQIVFTYKNNPNGSIENIAGIRNKQGNVLGMMPHPERAVEELLGSDDGLKLFKSMIANWRDSYAINA

Sequences:

>Translated_228_residues
MKFAVIVFPGSNCDRDMYHAVKEVAGAEAELVWYTETDKLEGVDGILLPGGFSYGDYLRSGSMASTSDVMHKIREHAAKG
KPVLGVCNGFQILTESGLLPGALMRNKHLSFMCHQEELVVEDNQTFFTSLYEKKEVVRFPIAHGEGSYFCDEATLKELQA
NNQIVFTYKNNPNGSIENIAGIRNKQGNVLGMMPHPERAVEELLGSDDGLKLFKSMIANWRDSYAINA
>Mature_228_residues
MKFAVIVFPGSNCDRDMYHAVKEVAGAEAELVWYTETDKLEGVDGILLPGGFSYGDYLRSGSMASTSDVMHKIREHAAKG
KPVLGVCNGFQILTESGLLPGALMRNKHLSFMCHQEELVVEDNQTFFTSLYEKKEVVRFPIAHGEGSYFCDEATLKELQA
NNQIVFTYKNNPNGSIENIAGIRNKQGNVLGMMPHPERAVEELLGSDDGLKLFKSMIANWRDSYAINA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=185, Percent_Identity=31.3513513513514, Blast_Score=64, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=201, Percent_Identity=31.8407960199005, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582111, Length=234, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24582109, Length=234, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137292, Length=234, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_OCEIH (Q8ES97)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691665.1
- ProteinModelPortal:   Q8ES97
- SMR:   Q8ES97
- GeneID:   1016268
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0744
- NMPDR:   fig|221109.1.peg.752
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- BioCyc:   OIHE221109:OB0744-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 25303; Mature: 25303

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVIVFPGSNCDRDMYHAVKEVAGAEAELVWYTETDKLEGVDGILLPGGFSYGDYLRS
CEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHHHC
GSMASTSDVMHKIREHAAKGKPVLGVCNGFQILTESGLLPGALMRNKHLSFMCHQEELVV
CCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCHHHHHCCCCEEEECCCEEEE
EDNQTFFTSLYEKKEVVRFPIAHGEGSYFCDEATLKELQANNQIVFTYKNNPNGSIENIA
ECCCHHHHHHHHHHHHEEEEEECCCCCEEECHHHHHHHHCCCEEEEEEECCCCCCHHHHH
GIRNKQGNVLGMMPHPERAVEELLGSDDGLKLFKSMIANWRDSYAINA
HCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKFAVIVFPGSNCDRDMYHAVKEVAGAEAELVWYTETDKLEGVDGILLPGGFSYGDYLRS
CEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCCHHHHHHC
GSMASTSDVMHKIREHAAKGKPVLGVCNGFQILTESGLLPGALMRNKHLSFMCHQEELVV
CCCCCHHHHHHHHHHHHHCCCCEEEECCCEEEECCCCCCCHHHHHCCCCEEEECCCEEEE
EDNQTFFTSLYEKKEVVRFPIAHGEGSYFCDEATLKELQANNQIVFTYKNNPNGSIENIA
ECCCHHHHHHHHHHHHEEEEEECCCCCEEECHHHHHHHHCCCEEEEEEECCCCCCHHHHH
GIRNKQGNVLGMMPHPERAVEELLGSDDGLKLFKSMIANWRDSYAINA
HCCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376