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The map label for this gene is hemA

Identifier: 229918357

GI number: 229918357

Start: 2608466

End: 2609812

Strand: Direct

Name: hemA

Synonym: EAT1b_2642

Alternate gene names: 229918357

Gene position: 2608466-2609812 (Clockwise)

Preceding gene: 229918356

Following gene: 229918358

Centisome position: 86.95

GC content: 50.04

Gene sequence:

>1347_bases
ATGCATATTGTCGTCGTTGGACTAAATAACAAGACAGCCCCTGTCGCGATTCGGGAGCAGTTCTCGTTTGGGGAGCAAGA
AATCGTGGATGCGATGATTGCACTTCGCGAAGAGAAGAGCATTTTCGAGTCGGTTATTTTGTCTACGTGTAACCGGACGG
AGCTGTACGTCGTGACAGACCAACTCCATACTGGACGTTATTACACGAAACGTTTCTTGGCGAACTGGTTCAACCTAGAG
ATGGAGCAGTTCACACCATACTTGTCGATTCGAGAAGGGGAAGAGGCGATTCGCCACTTGTTCCGTGTCACGTCGGGCCT
CGACTCGATGATCATCGGGGAAACACAAATTTTAGGTCAAGTGAAGACGAGTTTCTTCCGTGCCCAGGAGCATGGAACGA
CTGGAACGGTCTTCAACAAATTATTCAAAGAAGCGGTCACACTCGCCAAGCGCGCCCATACGGACACGCAAATTGGGGAA
ATGTCTGTATCGGTCAGTTCGGCTGCCGTGACGCTTGCGCAAGAGATGTATCAACAGCTCGAAGACAAACAAGTCGTCGT
CGTCGGAGCCGGTGAAACGGGTGAATTGACGACACTCAATTTATTTGAAGCCGGTGCGAAACAAATCGCTGTCTTCAACC
GGACGGAGAGCAAGGCAAAAGCTGTCGCGGACAAGTTCAAAGGTCGTGCCCATTCGATTCGTGAAATCGCATGTGGATTA
CTCGATGCGGATATTTTAATCAGTTCGACTGGCGCAAAAGAGGCGGTCATCGGATACGACGATGTGGCGGCTGCACAGTT
GTTGCGTCGTGAACGTCCGCTCCTTCTCATTGACATCGCTGTGCCGCGAGATATCGATCCAGCGGTCGCGACACTTCCGG
GTGTTCATTTGTTCGATGTCGATGATTTGAACGGAATCGTCAACAAAAATCTTGAGGCGCGTCTCGTCGAGGCTGAAAAG
ATTGAAATGAAGATCGATGAAGCGATTCAAGAGTTCCAAACATGGCTCGTCACACTGGGTGTTGTCCCAATCATGAACGA
GTTGCGTGCCCGTGCCCTTGATATTCAAGAAGATACGATGACGAGTCTTGAGCGTAAGCTCGACCACTTGTCAGCACGAG
ACAAGAAAGTCATCGGGAAGCATATGAAGTCCATCATCAACCAAATGCTTCGTGACCCGATCGACTATATTAAAGATGCA
GCGGCACAACCAGATGCGAACGTTCGAATCGCTCAATTCATCGAAACGTTCGGACTCGATGTCGAGTTGCCGGAACAACC
TGTAGACGAAGTGGAAGAAACAGATGCCACTTCTGCCAAAGCACCACTTCGCGCATTGATGCGCTAA

Upstream 100 bases:

>100_bases
AAGATTATAGTTACCAGATAAGAACTGTTATAATGTACGGTAGAGATTGAAATAAAGAAGAGATAACCGTCGGTGGATTT
TAGATGAGGGGAAGAGATAC

Downstream 100 bases:

>100_bases
CAAGACAAAAAGGCGACGCGTGTCGCCTTTTTCTATGAAGGAGAGATTGAACATGCGGAAAATCATTGTCGGCTCACGCC
GTTCCCAACTCGCCATGACT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MHIVVVGLNNKTAPVAIREQFSFGEQEIVDAMIALREEKSIFESVILSTCNRTELYVVTDQLHTGRYYTKRFLANWFNLE
MEQFTPYLSIREGEEAIRHLFRVTSGLDSMIIGETQILGQVKTSFFRAQEHGTTGTVFNKLFKEAVTLAKRAHTDTQIGE
MSVSVSSAAVTLAQEMYQQLEDKQVVVVGAGETGELTTLNLFEAGAKQIAVFNRTESKAKAVADKFKGRAHSIREIACGL
LDADILISSTGAKEAVIGYDDVAAAQLLRRERPLLLIDIAVPRDIDPAVATLPGVHLFDVDDLNGIVNKNLEARLVEAEK
IEMKIDEAIQEFQTWLVTLGVVPIMNELRARALDIQEDTMTSLERKLDHLSARDKKVIGKHMKSIINQMLRDPIDYIKDA
AAQPDANVRIAQFIETFGLDVELPEQPVDEVEETDATSAKAPLRALMR

Sequences:

>Translated_448_residues
MHIVVVGLNNKTAPVAIREQFSFGEQEIVDAMIALREEKSIFESVILSTCNRTELYVVTDQLHTGRYYTKRFLANWFNLE
MEQFTPYLSIREGEEAIRHLFRVTSGLDSMIIGETQILGQVKTSFFRAQEHGTTGTVFNKLFKEAVTLAKRAHTDTQIGE
MSVSVSSAAVTLAQEMYQQLEDKQVVVVGAGETGELTTLNLFEAGAKQIAVFNRTESKAKAVADKFKGRAHSIREIACGL
LDADILISSTGAKEAVIGYDDVAAAQLLRRERPLLLIDIAVPRDIDPAVATLPGVHLFDVDDLNGIVNKNLEARLVEAEK
IEMKIDEAIQEFQTWLVTLGVVPIMNELRARALDIQEDTMTSLERKLDHLSARDKKVIGKHMKSIINQMLRDPIDYIKDA
AAQPDANVRIAQFIETFGLDVELPEQPVDEVEETDATSAKAPLRALMR
>Mature_448_residues
MHIVVVGLNNKTAPVAIREQFSFGEQEIVDAMIALREEKSIFESVILSTCNRTELYVVTDQLHTGRYYTKRFLANWFNLE
MEQFTPYLSIREGEEAIRHLFRVTSGLDSMIIGETQILGQVKTSFFRAQEHGTTGTVFNKLFKEAVTLAKRAHTDTQIGE
MSVSVSSAAVTLAQEMYQQLEDKQVVVVGAGETGELTTLNLFEAGAKQIAVFNRTESKAKAVADKFKGRAHSIREIACGL
LDADILISSTGAKEAVIGYDDVAAAQLLRRERPLLLIDIAVPRDIDPAVATLPGVHLFDVDDLNGIVNKNLEARLVEAEK
IEMKIDEAIQEFQTWLVTLGVVPIMNELRARALDIQEDTMTSLERKLDHLSARDKKVIGKHMKSIINQMLRDPIDYIKDA
AAQPDANVRIAQFIETFGLDVELPEQPVDEVEETDATSAKAPLRALMR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=421, Percent_Identity=34.2042755344418, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_EXISA (C4L4J5)

Other databases:

- EMBL:   CP001615
- RefSeq:   YP_002887003.1
- GeneID:   7869655
- GenomeReviews:   CP001615_GR
- KEGG:   eat:EAT1b_2642
- OMA:   LLIDIAN
- ProtClustDB:   CLSK2489683
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 49913; Mature: 49913

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVVVGLNNKTAPVAIREQFSFGEQEIVDAMIALREEKSIFESVILSTCNRTELYVVTD
CEEEEEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
QLHTGRYYTKRFLANWFNLEMEQFTPYLSIREGEEAIRHLFRVTSGLDSMIIGETQILGQ
CCCCCHHHHHHHHHHHHCCCHHHCCCCCEECCHHHHHHHHHHHHCCCCHHHHCHHHHHHH
VKTSFFRAQEHGTTGTVFNKLFKEAVTLAKRAHTDTQIGEMSVSVSSAAVTLAQEMYQQL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEHHHHHHHHHHHHHHHC
EDKQVVVVGAGETGELTTLNLFEAGAKQIAVFNRTESKAKAVADKFKGRAHSIREIACGL
CCCEEEEEECCCCCCEEEEHHHHCCCHHEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHH
LDADILISSTGAKEAVIGYDDVAAAQLLRRERPLLLIDIAVPRDIDPAVATLPGVHLFDV
HCHHHEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCEEEEC
DDLNGIVNKNLEARLVEAEKIEMKIDEAIQEFQTWLVTLGVVPIMNELRARALDIQEDTM
HHHHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TSLERKLDHLSARDKKVIGKHMKSIINQMLRDPIDYIKDAAAQPDANVRIAQFIETFGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHCCC
VELPEQPVDEVEETDATSAKAPLRALMR
CCCCCCCHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MHIVVVGLNNKTAPVAIREQFSFGEQEIVDAMIALREEKSIFESVILSTCNRTELYVVTD
CEEEEEECCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
QLHTGRYYTKRFLANWFNLEMEQFTPYLSIREGEEAIRHLFRVTSGLDSMIIGETQILGQ
CCCCCHHHHHHHHHHHHCCCHHHCCCCCEECCHHHHHHHHHHHHCCCCHHHHCHHHHHHH
VKTSFFRAQEHGTTGTVFNKLFKEAVTLAKRAHTDTQIGEMSVSVSSAAVTLAQEMYQQL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEHHHHHHHHHHHHHHHC
EDKQVVVVGAGETGELTTLNLFEAGAKQIAVFNRTESKAKAVADKFKGRAHSIREIACGL
CCCEEEEEECCCCCCEEEEHHHHCCCHHEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHH
LDADILISSTGAKEAVIGYDDVAAAQLLRRERPLLLIDIAVPRDIDPAVATLPGVHLFDV
HCHHHEEECCCCCCEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCEEEEC
DDLNGIVNKNLEARLVEAEKIEMKIDEAIQEFQTWLVTLGVVPIMNELRARALDIQEDTM
HHHHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TSLERKLDHLSARDKKVIGKHMKSIINQMLRDPIDYIKDAAAQPDANVRIAQFIETFGLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHCCC
VELPEQPVDEVEETDATSAKAPLRALMR
CCCCCCCHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA