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The map label for this gene is sdhA [H]

Identifier: 229918343

GI number: 229918343

Start: 2593897

End: 2595654

Strand: Direct

Name: sdhA [H]

Synonym: EAT1b_2628

Alternate gene names: 229918343

Gene position: 2593897-2595654 (Clockwise)

Preceding gene: 229918342

Following gene: 229918344

Centisome position: 86.47

GC content: 52.56

Gene sequence:

>1758_bases
ATGGCAAATCAAAGTTTGATCGTCATCGGTGGCGGTCTAGCTGGACTCATGGCGACAATCAAGTCGGCAGAGATGGGTGT
TCCGGTAAAACTATTCTCGCTTGTACCGGTCAAGCGTTCACATTCAGTTTGTGCCCAAGGTGGGATTAACGGGGCCGTCA
ACACGAAAGGGGAAGGTGACTCTCCTTGGCAACACTTTGACGACACGGTATACGGAGGCGACTTCCTCGCCAACCAACCG
CCTGTCCAAAAGATGGCGGAGAATGCTCCGAAAATCATTCACATGTTCGACCGGATGGGCGTCATGTTCAACCGTACGCC
AGAAGGTCTCTTAGACTTCCGTCGTTTCGGTGGAACGCTTCACCACCGTACGGCATATGCTGGAGCGACGACAGGACAGC
AACTTCTCTATGCACTCGATGAGCAGGTTCGTCGTTACGAAGCGCAAGGTCTCGTCGAGAAGTATGAAGGATGGGAATTC
CTTCGCGCCGTCATCGACGAAGAAGGCATCTGCCGCGGTGCAGTCTGTCAGGATTTGCGCTCCATGGAAATTAAAGCGTT
CCCATCGGATGCGGTCATCTTGGCGACAGGTGGCCCAGGGGTCATCTTCGGTAAGTCGACTAACTCGGTCATCAACACAG
GACAGGCAGCGGCAGCGGTTTACCGCCAAGGCGCGGTCTACGCGAACGGGGAGTTCATCCAAATTCACCCGACGGCGATT
CCGGGGGACGACAAACTTCGTCTCATGAGTGAGTCGGCTCGTGGAGAAGGTGGACGTGTCTGGACATATAAAGACGGGAA
GCCATGGTACTTCCTCGAAGAGAAATATCCAGCTTACGGAAACCTCGTACCGCGTGACATCGCGACACGTGAGATCTTCG
ACGTATGTGTCAACCAAAAACTCGGCGTCAACGGCGAGAACATGGTTTACCTCGACTTGTCTCATAAAGATTCGAAAGAA
CTCGACATCAAACTCGGTGGAATCCTCGAAATCTACGAGAAATTCGTAGGGGACGACCCACGTAAAGTACCGATGAAAAT
CTTCCCGGCAGTCCACTATTCGATGGGCGGACTATGGGTCGACTACGATCAGATGACGAACATTCCGGGTCTCTTCGCAG
CAGGCGAATGTGACTACTCGATGCACGGGGCAAACCGTCTCGGTGCGAACTCGCTTCTTTCAGCCGTACATGGCGGAATG
GAAGCAGGGCCTGCGGCCGTCAACTACATGCGTGGTCTTGACCAAGCGACAGAAAGCGTCTCAGAAGCGCTCTTTAACTT
CAACGAACGTGAAGAAATCGAGCGATTCAACAACATCCTTGCGATGGATGGAACAGAGAATGCGTATCAGATTCACCGTG
AACTCGGTGAACTGATGACGGACAACGTCACAGTTGTTCGCTACAATGACAAACTTGAAGCGACCGACAAGAAAATCCAA
GAATTGCGTGAACGTTTCCATAAGATCTCAGCTACGGATACGGCACGTTGGAGCAACCAAGGGGCATCGTTCATTCGTCA
ACTCGACCACATGCTCGACCTCGCACGCGTCATCACACTTGGCGCACTCAAGCGGGACGAGAGCCGTGGGGCCCATTACA
AACCGGAGTTCCCGGAACGTAATGATGAGCAGTTCATGAAGACGACGATGGCACGTTACAAAGATGGGGAAGTCGATATC
TCGTATGAAGACATCGATGTTTCGTTAATCCCGCCACGTAAACGGGATTACTCGAAGAAAGGGGCGAAGACGAAATGA

Upstream 100 bases:

>100_bases
ATGAGCTACGTATCAGGTGTCGTGTTCTTGGCACTATCTTTTGTCGGCATCCGTTCGATTTTGACGTTTGCAGGCATCTT
GTAATTAGGGGGAATTTTAC

Downstream 100 bases:

>100_bases
CGACGCCAATGCAATCTGAACAAAAAGACATCCGCTTCATCATTGAACGCCAAGATGGACCGGATCAAGCGACGTATACG
GAAGAATTCACGGTACCATA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MANQSLIVIGGGLAGLMATIKSAEMGVPVKLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWQHFDDTVYGGDFLANQP
PVQKMAENAPKIIHMFDRMGVMFNRTPEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRRYEAQGLVEKYEGWEF
LRAVIDEEGICRGAVCQDLRSMEIKAFPSDAVILATGGPGVIFGKSTNSVINTGQAAAAVYRQGAVYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGVNGENMVYLDLSHKDSKE
LDIKLGGILEIYEKFVGDDPRKVPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGANRLGANSLLSAVHGGM
EAGPAAVNYMRGLDQATESVSEALFNFNEREEIERFNNILAMDGTENAYQIHRELGELMTDNVTVVRYNDKLEATDKKIQ
ELRERFHKISATDTARWSNQGASFIRQLDHMLDLARVITLGALKRDESRGAHYKPEFPERNDEQFMKTTMARYKDGEVDI
SYEDIDVSLIPPRKRDYSKKGAKTK

Sequences:

>Translated_585_residues
MANQSLIVIGGGLAGLMATIKSAEMGVPVKLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWQHFDDTVYGGDFLANQP
PVQKMAENAPKIIHMFDRMGVMFNRTPEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRRYEAQGLVEKYEGWEF
LRAVIDEEGICRGAVCQDLRSMEIKAFPSDAVILATGGPGVIFGKSTNSVINTGQAAAAVYRQGAVYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGVNGENMVYLDLSHKDSKE
LDIKLGGILEIYEKFVGDDPRKVPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGANRLGANSLLSAVHGGM
EAGPAAVNYMRGLDQATESVSEALFNFNEREEIERFNNILAMDGTENAYQIHRELGELMTDNVTVVRYNDKLEATDKKIQ
ELRERFHKISATDTARWSNQGASFIRQLDHMLDLARVITLGALKRDESRGAHYKPEFPERNDEQFMKTTMARYKDGEVDI
SYEDIDVSLIPPRKRDYSKKGAKTK
>Mature_584_residues
ANQSLIVIGGGLAGLMATIKSAEMGVPVKLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWQHFDDTVYGGDFLANQPP
VQKMAENAPKIIHMFDRMGVMFNRTPEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRRYEAQGLVEKYEGWEFL
RAVIDEEGICRGAVCQDLRSMEIKAFPSDAVILATGGPGVIFGKSTNSVINTGQAAAAVYRQGAVYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGVNGENMVYLDLSHKDSKEL
DIKLGGILEIYEKFVGDDPRKVPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGANRLGANSLLSAVHGGME
AGPAAVNYMRGLDQATESVSEALFNFNEREEIERFNNILAMDGTENAYQIHRELGELMTDNVTVVRYNDKLEATDKKIQE
LRERFHKISATDTARWSNQGASFIRQLDHMLDLARVITLGALKRDESRGAHYKPEFPERNDEQFMKTTMARYKDGEVDIS
YEDIDVSLIPPRKRDYSKKGAKTK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=604, Percent_Identity=29.635761589404, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1790597, Length=569, Percent_Identity=33.0404217926186, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=31.7725752508361, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1788928, Length=554, Percent_Identity=29.9638989169675, Blast_Score=175, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17505833, Length=603, Percent_Identity=30.8457711442786, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=602, Percent_Identity=31.063122923588, Blast_Score=228, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6322701, Length=587, Percent_Identity=31.3458262350937, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322416, Length=588, Percent_Identity=30.2721088435374, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17137288, Length=596, Percent_Identity=30.7046979865772, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24655642, Length=596, Percent_Identity=30.7046979865772, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24655647, Length=596, Percent_Identity=30.7046979865772, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24663005, Length=606, Percent_Identity=30.3630363036304, Blast_Score=205, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65073; Mature: 64941

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQSLIVIGGGLAGLMATIKSAEMGVPVKLFSLVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCC
SPWQHFDDTVYGGDFLANQPPVQKMAENAPKIIHMFDRMGVMFNRTPEGLLDFRRFGGTL
CCHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCEECCCHHHHHHHHHHCCCH
HHRTAYAGATTGQQLLYALDEQVRRYEAQGLVEKYEGWEFLRAVIDEEGICRGAVCQDLR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHH
SMEIKAFPSDAVILATGGPGVIFGKSTNSVINTGQAAAAVYRQGAVYANGEFIQIHPTAI
HCEEEECCCCEEEEEECCCEEEEECCCCCHHHCCHHHHHHHHCCCEEECCEEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
LGVNGENMVYLDLSHKDSKELDIKLGGILEIYEKFVGDDPRKVPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGANRLGANSLLSAVHGGMEAGPAAVNYMRGLDQATESV
EHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
SEALFNFNEREEIERFNNILAMDGTENAYQIHRELGELMTDNVTVVRYNDKLEATDKKIQ
HHHHHCCCHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHH
ELRERFHKISATDTARWSNQGASFIRQLDHMLDLARVITLGALKRDESRGAHYKPEFPER
HHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NDEQFMKTTMARYKDGEVDISYEDIDVSLIPPRKRDYSKKGAKTK
CHHHHHHHHHHHCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANQSLIVIGGGLAGLMATIKSAEMGVPVKLFSLVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCC
SPWQHFDDTVYGGDFLANQPPVQKMAENAPKIIHMFDRMGVMFNRTPEGLLDFRRFGGTL
CCHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCEECCCHHHHHHHHHHCCCH
HHRTAYAGATTGQQLLYALDEQVRRYEAQGLVEKYEGWEFLRAVIDEEGICRGAVCQDLR
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHH
SMEIKAFPSDAVILATGGPGVIFGKSTNSVINTGQAAAAVYRQGAVYANGEFIQIHPTAI
HCEEEECCCCEEEEEECCCEEEEECCCCCHHHCCHHHHHHHHCCCEEECCEEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCC
LGVNGENMVYLDLSHKDSKELDIKLGGILEIYEKFVGDDPRKVPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTNIPGLFAAGECDYSMHGANRLGANSLLSAVHGGMEAGPAAVNYMRGLDQATESV
EHHHHCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
SEALFNFNEREEIERFNNILAMDGTENAYQIHRELGELMTDNVTVVRYNDKLEATDKKIQ
HHHHHCCCHHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHH
ELRERFHKISATDTARWSNQGASFIRQLDHMLDLARVITLGALKRDESRGAHYKPEFPER
HHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NDEQFMKTTMARYKDGEVDISYEDIDVSLIPPRKRDYSKKGAKTK
CHHHHHHHHHHHCCCCCEEEEEECEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]