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The map label for this gene is menB [H]

Identifier: 229918092

GI number: 229918092

Start: 2324521

End: 2325345

Strand: Reverse

Name: menB [H]

Synonym: EAT1b_2372

Alternate gene names: 229918092

Gene position: 2325345-2324521 (Counterclockwise)

Preceding gene: 229918093

Following gene: 229918091

Centisome position: 77.51

GC content: 51.03

Gene sequence:

>825_bases
ATGGAATCAGTAGCGAACTGGACATCGGTCCGGACGTATGAAGACATTAAATATGAAACGTGGAACGGGATTGCCAAAAT
CACCATCAACCGTCCCGAAGTGCGCAATGCATTCCGTCCGTTGACGGTCAACGAATTGATTGATGCATTTGCTCGCGCGC
GCGACGATAAAGAAGTCGGCGTCATCATCTTGACAGGTGAAGGCGAAAAGGCATTCTGTTCAGGTGGAGACCAAAAAGTT
CGCGGACATGGTGGCTACGTCGGGGAAGATGAAATCCCACGCTTGAACGTCCTCGACCTTCAGCGCTTGATTCGCGTCAT
TCCAAAACCGGTCATTGCCATGGTCGCAGGTTTCGCAATCGGCGGAGGACACGTCCTTCACGTCGTCTGTGACTTGACGA
TTGCAGCGGACAACGCTCGCTTCGGACAAACAGGTCCTAAAGTCGGTTCGTTCGATGCAGGATACGGTTCTGGATACTTG
GCACGCATCATCGGCCATAAGAAAGCTCGTGAAATCTGGTACCTTTGCCGTCAATACGATGCACAAGAAGCACTCGACAT
GGGACTCGTCAACACGGTCGTCCCACTCGATCAACTCGAAGCAGAAACGATCAAGTGGTGCCAAGAAATCTTACAACACT
CACCTACAGCGCTTCGCTTCTTGAAAGCAGCAATGAACGCAGATACAGATGGTCTTGCCGGACTTCAGCAACTCGCTGGA
GACGCAACGCTTCTCTACTACACGACAGATGAAGCAAAAGAAGGACGCGATGCGTTCAAAGAAAAACGTGACCCTGACTT
CGGTCAATTCCCACGTTTCCCTTAA

Upstream 100 bases:

>100_bases
AAAATCTATGAAATTTCAAACGCAGGGCATGCTCCTCATATCGAGAATGCATCAGAGTTTGGTACAATAATAAAGAAATT
GATTTTAGGGGGTATTTAAA

Downstream 100 bases:

>100_bases
TTGTTGAGAGAGTAGCGATTTCGCTACTCTTTTTTTGGAGGTGACCGCTATGTATGAATGGATTCAGAAACAGCAAGCGT
CACATATCGCCCTTGTGACA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MESVANWTSVRTYEDIKYETWNGIAKITINRPEVRNAFRPLTVNELIDAFARARDDKEVGVIILTGEGEKAFCSGGDQKV
RGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGFAIGGGHVLHVVCDLTIAADNARFGQTGPKVGSFDAGYGSGYL
ARIIGHKKAREIWYLCRQYDAQEALDMGLVNTVVPLDQLEAETIKWCQEILQHSPTALRFLKAAMNADTDGLAGLQQLAG
DATLLYYTTDEAKEGRDAFKEKRDPDFGQFPRFP

Sequences:

>Translated_274_residues
MESVANWTSVRTYEDIKYETWNGIAKITINRPEVRNAFRPLTVNELIDAFARARDDKEVGVIILTGEGEKAFCSGGDQKV
RGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGFAIGGGHVLHVVCDLTIAADNARFGQTGPKVGSFDAGYGSGYL
ARIIGHKKAREIWYLCRQYDAQEALDMGLVNTVVPLDQLEAETIKWCQEILQHSPTALRFLKAAMNADTDGLAGLQQLAG
DATLLYYTTDEAKEGRDAFKEKRDPDFGQFPRFP
>Mature_274_residues
MESVANWTSVRTYEDIKYETWNGIAKITINRPEVRNAFRPLTVNELIDAFARARDDKEVGVIILTGEGEKAFCSGGDQKV
RGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGFAIGGGHVLHVVCDLTIAADNARFGQTGPKVGSFDAGYGSGYL
ARIIGHKKAREIWYLCRQYDAQEALDMGLVNTVVPLDQLEAETIKWCQEILQHSPTALRFLKAAMNADTDGLAGLQQLAG
DATLLYYTTDEAKEGRDAFKEKRDPDFGQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=247, Percent_Identity=32.3886639676113, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI31542718, Length=261, Percent_Identity=31.0344827586207, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=31.0344827586207, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=28.6384976525822, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI157694516, Length=210, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=210, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI70995211, Length=232, Percent_Identity=27.1551724137931, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1788597, Length=264, Percent_Identity=70.8333333333333, Blast_Score=393, Evalue=1e-111,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=32.2448979591837, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI221142681, Length=262, Percent_Identity=32.824427480916, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=27.9245283018868, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=31.0344827586207, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788682, Length=178, Percent_Identity=27.5280898876405, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=264, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI25145438, Length=257, Percent_Identity=32.6848249027237, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=221, Percent_Identity=29.8642533936652, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=189, Percent_Identity=32.8042328042328, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=219, Percent_Identity=27.8538812785388, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=25.3968253968254, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17534483, Length=261, Percent_Identity=27.2030651340996, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=275, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=222, Percent_Identity=27.9279279279279, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=266, Percent_Identity=34.9624060150376, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653477, Length=266, Percent_Identity=34.9624060150376, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653139, Length=255, Percent_Identity=29.4117647058824, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=33.8624338624339, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI19922422, Length=274, Percent_Identity=24.4525547445255, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30303; Mature: 30303

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVANWTSVRTYEDIKYETWNGIAKITINRPEVRNAFRPLTVNELIDAFARARDDKEVG
CCCCCCHHHHCHHHHCCEECCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCCCCEE
VIILTGEGEKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGFAI
EEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHC
GGGHVLHVVCDLTIAADNARFGQTGPKVGSFDAGYGSGYLARIIGHKKAREIWYLCRQYD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHC
AQEALDMGLVNTVVPLDQLEAETIKWCQEILQHSPTALRFLKAAMNADTDGLAGLQQLAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCC
DATLLYYTTDEAKEGRDAFKEKRDPDFGQFPRFP
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MESVANWTSVRTYEDIKYETWNGIAKITINRPEVRNAFRPLTVNELIDAFARARDDKEVG
CCCCCCHHHHCHHHHCCEECCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHHCCCCCCEE
VIILTGEGEKAFCSGGDQKVRGHGGYVGEDEIPRLNVLDLQRLIRVIPKPVIAMVAGFAI
EEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHC
GGGHVLHVVCDLTIAADNARFGQTGPKVGSFDAGYGSGYLARIIGHKKAREIWYLCRQYD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHC
AQEALDMGLVNTVVPLDQLEAETIKWCQEILQHSPTALRFLKAAMNADTDGLAGLQQLAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCC
DATLLYYTTDEAKEGRDAFKEKRDPDFGQFPRFP
CCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]