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The map label for this gene is hom [H]

Identifier: 229137830

GI number: 229137830

Start: 1777319

End: 1778638

Strand: Reverse

Name: hom [H]

Synonym: Nmul_A1551

Alternate gene names: 229137830

Gene position: 1778638-1777319 (Counterclockwise)

Preceding gene: 82702681

Following gene: 82702679

Centisome position: 55.86

GC content: 56.14

Gene sequence:

>1320_bases
ATGAAACCTATCCATGTGGGCCTGTTGGGGGCAGGCACGGTCGGCAGCGGCACGTTCGCCGTGCTCAAACGCAATCAGGA
AGAGATCACCCGCCGCGCCGGCCGCAGTATCGTCGTTCGCATGATTGCTGATCGAGAGGAAGAGAAGGCCCGTCAGATCG
CAGGCGACGATGAGGTCATCGTCACACGCGATGCGAATGAGGTGGTGATGAATCCCGATATCGATATCGTGGTCGAACTG
ATCGGCGGCTACACCGCGGCCAGGGACCTGATACTGAAGGCTATCGAGAATGGCAAGCATGTCATTACCGCCAACAAGGC
ATTGCTTGCTTCACATGGGACCGAAATCTTCGCCGCGGCGCAGAAGAAAGGCGTAATGGTGGCGTTCGAAGCGGCGGTGG
CGGGAGGCATTCCTATAATCAAGGCTCTGCGTGAGGGATTGACTGCCAACCGCATCGAGTGGATAGCCGGCATCATCAAT
GGCACGAGCAACTTCATTCTCTCGGAAATGCGGGATAAGGGGTTGACGTTCGAAACCGTATTGAAGCAGGCGCAAAAACT
GGGTTATGCCGAAGCCGATCCCACTTTTGACATCGAGGGCATCGATGCGGCGCATAAACTCACGATCATGGCCTCGATCG
CCTTTGGCATTCCAATGCAGTTTGACAAGGTATATACCGAGGGTATAACCAAATTGACCCGCGAGGATATTCGTTATGCG
GAGGAACTGGGTTATCGCATCAAGCTGTTGGGCATTACGAAACGTACGTCCGGAGGAATCGAGTTGCGTGTGCATCCGAC
ACTCATCCCTGCTCGAAGACTGATCGCCAATGTCGAGGGGGTGATGAATGCCATCGTGGTGAGAGGCGATGCGGTAGGCT
CTACCCTCTATTATGGTCCGGGAGCGGGTGCCGAACCTACAGGGAGTTCAGTCGTGGCAGACCTGGTGGATGTAACTCGC
ATGCACACAGCCGATCCCAAGCACCGCGTTCCTCATCTCGCCTTCCAGCCAGGCCGCCTGTCGGATACGCCGATCCTCAC
GATGGACGAGGTGGAAACGTCTTATTACCTGCGGCTGCGGGTCATGGACAAACCTGGGGCCCTGGCCGATATCACGCGGG
TGCTTGCGGACCTCGGCATTTCCATCGAAGCCATGATGCAGAAAGAGCCAAGCGAAGGCGAAGACCAGGTGGATATCATT
ATGCTCACGCATTTGGCGGTGGAAAGAAACGTTAACGATGCGATCGCCCGAATAAAGCGATTGCCCATAACGACCGGCAA
GGTGACCCGCATCCGGCTGGAGCATCTGGGCAGCAAATAA

Upstream 100 bases:

>100_bases
AGGCGAACTCGACTTCTGTAAACGACAACGCCGCGTACGAACAAAATCCCTTTCAGCAAATATGGCAAATATGTCCGAAA
AATTCATCATTACCGAAGAT

Downstream 100 bases:

>100_bases
TTGACATTACCGGTTATGGTCAACCCCCGCTAGTGTCCGGGGTAAGATCGCTGACATTTTCAGGGCAAACTCATCAGCAA
TATGGCGGATAGCGGGATGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKPIHVGLLGAGTVGSGTFAVLKRNQEEITRRAGRSIVVRMIADREEEKARQIAGDDEVIVTRDANEVVMNPDIDIVVEL
IGGYTAARDLILKAIENGKHVITANKALLASHGTEIFAAAQKKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIIN
GTSNFILSEMRDKGLTFETVLKQAQKLGYAEADPTFDIEGIDAAHKLTIMASIAFGIPMQFDKVYTEGITKLTREDIRYA
EELGYRIKLLGITKRTSGGIELRVHPTLIPARRLIANVEGVMNAIVVRGDAVGSTLYYGPGAGAEPTGSSVVADLVDVTR
MHTADPKHRVPHLAFQPGRLSDTPILTMDEVETSYYLRLRVMDKPGALADITRVLADLGISIEAMMQKEPSEGEDQVDII
MLTHLAVERNVNDAIARIKRLPITTGKVTRIRLEHLGSK

Sequences:

>Translated_439_residues
MKPIHVGLLGAGTVGSGTFAVLKRNQEEITRRAGRSIVVRMIADREEEKARQIAGDDEVIVTRDANEVVMNPDIDIVVEL
IGGYTAARDLILKAIENGKHVITANKALLASHGTEIFAAAQKKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIIN
GTSNFILSEMRDKGLTFETVLKQAQKLGYAEADPTFDIEGIDAAHKLTIMASIAFGIPMQFDKVYTEGITKLTREDIRYA
EELGYRIKLLGITKRTSGGIELRVHPTLIPARRLIANVEGVMNAIVVRGDAVGSTLYYGPGAGAEPTGSSVVADLVDVTR
MHTADPKHRVPHLAFQPGRLSDTPILTMDEVETSYYLRLRVMDKPGALADITRVLADLGISIEAMMQKEPSEGEDQVDII
MLTHLAVERNVNDAIARIKRLPITTGKVTRIRLEHLGSK
>Mature_439_residues
MKPIHVGLLGAGTVGSGTFAVLKRNQEEITRRAGRSIVVRMIADREEEKARQIAGDDEVIVTRDANEVVMNPDIDIVVEL
IGGYTAARDLILKAIENGKHVITANKALLASHGTEIFAAAQKKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIIN
GTSNFILSEMRDKGLTFETVLKQAQKLGYAEADPTFDIEGIDAAHKLTIMASIAFGIPMQFDKVYTEGITKLTREDIRYA
EELGYRIKLLGITKRTSGGIELRVHPTLIPARRLIANVEGVMNAIVVRGDAVGSTLYYGPGAGAEPTGSSVVADLVDVTR
MHTADPKHRVPHLAFQPGRLSDTPILTMDEVETSYYLRLRVMDKPGALADITRVLADLGISIEAMMQKEPSEGEDQVDII
MLTHLAVERNVNDAIARIKRLPITTGKVTRIRLEHLGSK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=244, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786183, Length=147, Percent_Identity=29.2517006802721, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=236, Percent_Identity=30.5084745762712, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47723; Mature: 47723

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIHVGLLGAGTVGSGTFAVLKRNQEEITRRAGRSIVVRMIADREEEKARQIAGDDEVI
CCCEEEEEEECCCCCCCEEEEEECCHHHHHHHCCHHEEEHHHHCCCHHHHHHCCCCCCEE
VTRDANEVVMNPDIDIVVELIGGYTAARDLILKAIENGKHVITANKALLASHGTEIFAAA
EEECCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCEEEHHCCCCEEEHH
QKKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIINGTSNFILSEMRDKGLTFETV
HCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
LKQAQKLGYAEADPTFDIEGIDAAHKLTIMASIAFGIPMQFDKVYTEGITKLTREDIRYA
HHHHHHCCCCCCCCCEEECCCCCHHHHEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EELGYRIKLLGITKRTSGGIELRVHPTLIPARRLIANVEGVMNAIVVRGDAVGSTLYYGP
HHCCCEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
GAGAEPTGSSVVADLVDVTRMHTADPKHRVPHLAFQPGRLSDTPILTMDEVETSYYLRLR
CCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCEEECCCCCCCCCEEEHHCCCCEEEEEEE
VMDKPGALADITRVLADLGISIEAMMQKEPSEGEDQVDIIMLTHLAVERNVNDAIARIKR
EECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHH
LPITTGKVTRIRLEHLGSK
CCCCCCCEEEEEHHCCCCC
>Mature Secondary Structure
MKPIHVGLLGAGTVGSGTFAVLKRNQEEITRRAGRSIVVRMIADREEEKARQIAGDDEVI
CCCEEEEEEECCCCCCCEEEEEECCHHHHHHHCCHHEEEHHHHCCCHHHHHHCCCCCCEE
VTRDANEVVMNPDIDIVVELIGGYTAARDLILKAIENGKHVITANKALLASHGTEIFAAA
EEECCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCEEEHHCCCCEEEHH
QKKGVMVAFEAAVAGGIPIIKALREGLTANRIEWIAGIINGTSNFILSEMRDKGLTFETV
HCCCEEEEEECHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHH
LKQAQKLGYAEADPTFDIEGIDAAHKLTIMASIAFGIPMQFDKVYTEGITKLTREDIRYA
HHHHHHCCCCCCCCCEEECCCCCHHHHEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EELGYRIKLLGITKRTSGGIELRVHPTLIPARRLIANVEGVMNAIVVRGDAVGSTLYYGP
HHCCCEEEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHEEEEECCCCCCEEEECC
GAGAEPTGSSVVADLVDVTRMHTADPKHRVPHLAFQPGRLSDTPILTMDEVETSYYLRLR
CCCCCCCCHHHHHHHHHHHHHCCCCCHHCCCCEEECCCCCCCCCEEEHHCCCCEEEEEEE
VMDKPGALADITRVLADLGISIEAMMQKEPSEGEDQVDIIMLTHLAVERNVNDAIARIKR
EECCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHHH
LPITTGKVTRIRLEHLGSK
CCCCCCCEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]