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The map label for this gene is thrC [H]

Identifier: 82702679

GI number: 82702679

Start: 1775740

End: 1777173

Strand: Reverse

Name: thrC [H]

Synonym: Nmul_A1550

Alternate gene names: 82702679

Gene position: 1777173-1775740 (Counterclockwise)

Preceding gene: 229137830

Following gene: 82702675

Centisome position: 55.81

GC content: 54.18

Gene sequence:

>1434_bases
ATGCTCTACATTTCCACTCGTGGCGGCATGCCGCCTAAAAAGTTCTCCAGGATTCTTCTCGGCGGCCTTGCTCCGGATGG
CGGGCTGACGCTGCCGGAAACCTATCCCAGGTTCGATGACGCAAAATTGCAGGAACTGCGGGACATGGATTACCCGGAAC
TTGCGTTCGAGATCCTTTCCGGTTTTGCGGATGACATTCCTGCTGCGGACTTGCGCGCAATCATCGGGCGAACCTATACT
GCCCAGTCGTTTCAAAACGATGAAATCACGCCGCTTAAAACCCTGGAACCGGGGCTGCACATACTTGGTTTGTCGAATGG
CCCGACGCTGGCCTTCAAGGATATCGCCCTGCAATTGCTGGGCAACCTGTTCGAGTACGCGTTGGACAAGAATGGCGAGC
AGCTGAATATCCTCGGTGCAACTTCCGGCGATACCGGGCCGAGCGCAGAGTATGCCATGCGGGGCAAGCGCGGCATTCGT
GTGTTCATGCTTTCGCCGCATGGAAAAATGAGCCCGTTCCAGACAGCTCAAATGTTTTCCCTGCATGATCCGAATATTTT
CAATATCGCCATTCGCGGCGTGTTCGACGATTGCCAGGACATTATCAAGGCTGTCAGCAATGATTATGCCTTCAAGCAGA
AATACCGCATTGGTACGGTTAATTCCATAAACTGGGCACGCATTGCGGCGCAGACCGTTTATTACTTCAAAGGTTATTTT
GCTGCCACCCGCTCGAATACAGAGCAGGTATCTTTCGCGGTGCCATCGGGAAATTTCGGCAACATTTGCGCAGGGCACGT
GGCGCGCATGATGGGCCTGCCTATCAAAAAGCTGATACTTGCCACCAATGAAAATGATGTGCTGGATGAATTTTTCCGGA
CGGGACATTATCGCCCGCGCACGACCGCCGAGACCGTCCAGACCAGTAGTCCCTCGATGGATATTTCCAAGGCCTCGAAC
TTCGAGCGCTTCATTTTCGACTTAACCGGAAGAGATGCCGCCAAAGTGAAGGAATTATGGCAGGCAGTAGATGAGGGCGG
AGCCTTTGATCTCGCCGATACGCCCCTGTGGGAGAGAATCGAAGACTTTGGCCTTGTATCAGGGACCAGCAGTCATGCAG
ACCGAATCGCCACCATCCGCCGGGTGCATGACCGATATGGCTTGGTGATAGACCCGCATACAGCTGACGGCGTGAAAGCG
GGATTGGAACATCGTGACGCCAGCGTGCCGCTGATCTGTCTTGAAACGGCATTGCCAGTCAAATTCTCAGCAAGCATTGT
CGAGGCGATCGGACATGAGCCTGAGCGTCCCGCAGGATATGAGAATATTGAAGAAAAAGCACAGCGCTATGTAGTCATGG
ATGCTGACGCAGGGGCGGTCAAGGCGTTTATTGTGGAGCAGGCGGGGCCGCCCCAAACCGCGGCGGCGATATAA

Upstream 100 bases:

>100_bases
GATCGCTGACATTTTCAGGGCAAACTCATCAGCAATATGGCGGATAGCGGGATGAATTGCTTCACTTTTATCTTTTTGCG
AGTTTGTAGGATTTAGGATA

Downstream 100 bases:

>100_bases
GCTTGCGATGAGACGGGAGGTGGAGCACCGGTAAATATAAGCCGGCCGCAGCATCGCCCCCCATTTCGCCTTCCTTCGGC
AGATTCAGGACGAACAGCGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MLYISTRGGMPPKKFSRILLGGLAPDGGLTLPETYPRFDDAKLQELRDMDYPELAFEILSGFADDIPAADLRAIIGRTYT
AQSFQNDEITPLKTLEPGLHILGLSNGPTLAFKDIALQLLGNLFEYALDKNGEQLNILGATSGDTGPSAEYAMRGKRGIR
VFMLSPHGKMSPFQTAQMFSLHDPNIFNIAIRGVFDDCQDIIKAVSNDYAFKQKYRIGTVNSINWARIAAQTVYYFKGYF
AATRSNTEQVSFAVPSGNFGNICAGHVARMMGLPIKKLILATNENDVLDEFFRTGHYRPRTTAETVQTSSPSMDISKASN
FERFIFDLTGRDAAKVKELWQAVDEGGAFDLADTPLWERIEDFGLVSGTSSHADRIATIRRVHDRYGLVIDPHTADGVKA
GLEHRDASVPLICLETALPVKFSASIVEAIGHEPERPAGYENIEEKAQRYVVMDADAGAVKAFIVEQAGPPQTAAAI

Sequences:

>Translated_477_residues
MLYISTRGGMPPKKFSRILLGGLAPDGGLTLPETYPRFDDAKLQELRDMDYPELAFEILSGFADDIPAADLRAIIGRTYT
AQSFQNDEITPLKTLEPGLHILGLSNGPTLAFKDIALQLLGNLFEYALDKNGEQLNILGATSGDTGPSAEYAMRGKRGIR
VFMLSPHGKMSPFQTAQMFSLHDPNIFNIAIRGVFDDCQDIIKAVSNDYAFKQKYRIGTVNSINWARIAAQTVYYFKGYF
AATRSNTEQVSFAVPSGNFGNICAGHVARMMGLPIKKLILATNENDVLDEFFRTGHYRPRTTAETVQTSSPSMDISKASN
FERFIFDLTGRDAAKVKELWQAVDEGGAFDLADTPLWERIEDFGLVSGTSSHADRIATIRRVHDRYGLVIDPHTADGVKA
GLEHRDASVPLICLETALPVKFSASIVEAIGHEPERPAGYENIEEKAQRYVVMDADAGAVKAFIVEQAGPPQTAAAI
>Mature_477_residues
MLYISTRGGMPPKKFSRILLGGLAPDGGLTLPETYPRFDDAKLQELRDMDYPELAFEILSGFADDIPAADLRAIIGRTYT
AQSFQNDEITPLKTLEPGLHILGLSNGPTLAFKDIALQLLGNLFEYALDKNGEQLNILGATSGDTGPSAEYAMRGKRGIR
VFMLSPHGKMSPFQTAQMFSLHDPNIFNIAIRGVFDDCQDIIKAVSNDYAFKQKYRIGTVNSINWARIAAQTVYYFKGYF
AATRSNTEQVSFAVPSGNFGNICAGHVARMMGLPIKKLILATNENDVLDEFFRTGHYRPRTTAETVQTSSPSMDISKASN
FERFIFDLTGRDAAKVKELWQAVDEGGAFDLADTPLWERIEDFGLVSGTSSHADRIATIRRVHDRYGLVIDPHTADGVKA
GLEHRDASVPLICLETALPVKFSASIVEAIGHEPERPAGYENIEEKAQRYVVMDADAGAVKAFIVEQAGPPQTAAAI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=463, Percent_Identity=30.8855291576674, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI153792148, Length=454, Percent_Identity=33.7004405286344, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1786185, Length=426, Percent_Identity=30.7511737089202, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319901, Length=464, Percent_Identity=40.948275862069, Blast_Score=327, Evalue=3e-90,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52353; Mature: 52353

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYISTRGGMPPKKFSRILLGGLAPDGGLTLPETYPRFDDAKLQELRDMDYPELAFEILS
CEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
GFADDIPAADLRAIIGRTYTAQSFQNDEITPLKTLEPGLHILGLSNGPTLAFKDIALQLL
HHHCCCCHHHHHHHHCCCHHHCCCCCCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHH
GNLFEYALDKNGEQLNILGATSGDTGPSAEYAMRGKRGIRVFMLSPHGKMSPFQTAQMFS
HHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHEEE
LHDPNIFNIAIRGVFDDCQDIIKAVSNDYAFKQKYRIGTVNSINWARIAAQTVYYFKGYF
CCCCCEEEEEEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCHHHHHHHHHHHHHHEE
AATRSNTEQVSFAVPSGNFGNICAGHVARMMGLPIKKLILATNENDVLDEFFRTGHYRPR
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHCCCCCCC
TTAETVQTSSPSMDISKASNFERFIFDLTGRDAAKVKELWQAVDEGGAFDLADTPLWERI
CHHHHHHCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
EDFGLVSGTSSHADRIATIRRVHDRYGLVIDPHTADGVKAGLEHRDASVPLICLETALPV
HHCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCCEEEECCCCCC
KFSASIVEAIGHEPERPAGYENIEEKAQRYVVMDADAGAVKAFIVEQAGPPQTAAAI
CHHHHHHHHHCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCHHCCC
>Mature Secondary Structure
MLYISTRGGMPPKKFSRILLGGLAPDGGLTLPETYPRFDDAKLQELRDMDYPELAFEILS
CEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHH
GFADDIPAADLRAIIGRTYTAQSFQNDEITPLKTLEPGLHILGLSNGPTLAFKDIALQLL
HHHCCCCHHHHHHHHCCCHHHCCCCCCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHHH
GNLFEYALDKNGEQLNILGATSGDTGPSAEYAMRGKRGIRVFMLSPHGKMSPFQTAQMFS
HHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHEEE
LHDPNIFNIAIRGVFDDCQDIIKAVSNDYAFKQKYRIGTVNSINWARIAAQTVYYFKGYF
CCCCCEEEEEEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCCHHHHHHHHHHHHHHEE
AATRSNTEQVSFAVPSGNFGNICAGHVARMMGLPIKKLILATNENDVLDEFFRTGHYRPR
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHEEECCCCHHHHHHHHCCCCCCC
TTAETVQTSSPSMDISKASNFERFIFDLTGRDAAKVKELWQAVDEGGAFDLADTPLWERI
CHHHHHHCCCCCCCHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHH
EDFGLVSGTSSHADRIATIRRVHDRYGLVIDPHTADGVKAGLEHRDASVPLICLETALPV
HHCCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHCCCCCCCCEEEECCCCCC
KFSASIVEAIGHEPERPAGYENIEEKAQRYVVMDADAGAVKAFIVEQAGPPQTAAAI
CHHHHHHHHHCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEEEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]