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The map label for this gene is tuaD [H]

Identifier: 227826987

GI number: 227826987

Start: 589821

End: 591035

Strand: Direct

Name: tuaD [H]

Synonym: M1425_0644

Alternate gene names: 227826987

Gene position: 589821-591035 (Clockwise)

Preceding gene: 227826986

Following gene: 227826988

Centisome position: 22.61

GC content: 31.85

Gene sequence:

>1215_bases
ATGATAATAGGTATAGTAGGCTTAGGCTATGTAGGATTAGTAACTGGTGCAGTTTTAGCTGATCAAGGACATTACGTAAT
AGGTGTCGATATAGACGAGAAAAAGGTAAATGGATTAAATTGTAATAGAATACCAATTTATGAACCCGGTTTAGATGAGT
TAATAATGAAAAATAAGAAAAAAATACAATTTACTACAAACTATTCTGATCTATCTGATGCTGATATAGTTTTTATAGCA
GTTTCTACACCAACAATAAATGGAAAAATTTTTCTAGATTATATTTACTCAGCGGGAGAAAATTTACAAAAAATCTTGAA
TAAAGAATCCGTAATAGTAATAAAAAGTACAGTAATTCCAGGAACTTCAAGAAAGGTTAAGGAAATAACTAAGAGAGAAG
TAATAGCGAATCCAGAATTTTTAAGGGAAGGGAGTGCTATTATTGATACTAAACATCCTGAAAGGATAGTTATAGGTGGA
GATGATGAAAAAGCGATTAAGTTAATAGAAGATTTATGGTCATTTACTAATTCGCCGATAATAAAAACTTCAATGGAAGA
GGCTGAGTTAATAAAATACGCAGCAAATTCTTTTCTCGCTGTAAAGATTTCATTTATAAATGAGATTGCTAACCTATGTG
AAAAAATCCCAAATTGTGATATAAATAATATAGCAAAGGCAATCGGCATGGATAAGCGCATATCACCATATTTTTTAAAC
GCAGGACTAGGTTTCGGCGGATCATGTTTCCCTAAGGATACATTAGCTATTACCTCTTTTGCTAAAGATTTAGGAGAGAG
ACTACATATCGTAGAAGCTGCAATCGAGGTTAATAATGAAAGGCCCTTTAGAGCAGTCAAAATGATGGAAGATTTAATTG
GAAAATTAGAGAACAAGAGTATTTGTATATTAGGAATAGCATTCAAACCAAATACTGATGATACTAGAGAAAGTGTAGGT
CTAAAAATAGCTAAATTGATTAGAGAAAAAGGCGGTAAGGTTATAGTATACGATCCAAAAGCTAAAGCTGATTTAGAGAT
GGTCTCACTTGATGAGTGTATAAATAAAGCTGATGGGATAATAATTGCTACTGAATGGGATGAATTCAGAGGATTAGAGG
ATAGATTAAAAGGAAAATATGTAGTAGATGGAAGGAGAATCCTAAACTATAAAAAGTTAGAGAAAGGTAGATTTAAGGCA
ATAGGTGTTAGTTAA

Upstream 100 bases:

>100_bases
CAGATATAACAAAAGCTAAAAAGTTGCTAAATTGGGAGCCTAAATTATCCTTAGAAGAAGGGTTAAGGAAAACAATAGAT
TGGTTTAGGGGTGTAATTGA

Downstream 100 bases:

>100_bases
TGCATGCAGTAATAACTGCAGCTGGATTAGGCACTCGAATGTTACCCGCTTCTAAAGAAATTCCTAAGGAGATGTTTCCA
ATTCCCTTTAACAATGGATT

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MIIGIVGLGYVGLVTGAVLADQGHYVIGVDIDEKKVNGLNCNRIPIYEPGLDELIMKNKKKIQFTTNYSDLSDADIVFIA
VSTPTINGKIFLDYIYSAGENLQKILNKESVIVIKSTVIPGTSRKVKEITKREVIANPEFLREGSAIIDTKHPERIVIGG
DDEKAIKLIEDLWSFTNSPIIKTSMEEAELIKYAANSFLAVKISFINEIANLCEKIPNCDINNIAKAIGMDKRISPYFLN
AGLGFGGSCFPKDTLAITSFAKDLGERLHIVEAAIEVNNERPFRAVKMMEDLIGKLENKSICILGIAFKPNTDDTRESVG
LKIAKLIREKGGKVIVYDPKAKADLEMVSLDECINKADGIIIATEWDEFRGLEDRLKGKYVVDGRRILNYKKLEKGRFKA
IGVS

Sequences:

>Translated_404_residues
MIIGIVGLGYVGLVTGAVLADQGHYVIGVDIDEKKVNGLNCNRIPIYEPGLDELIMKNKKKIQFTTNYSDLSDADIVFIA
VSTPTINGKIFLDYIYSAGENLQKILNKESVIVIKSTVIPGTSRKVKEITKREVIANPEFLREGSAIIDTKHPERIVIGG
DDEKAIKLIEDLWSFTNSPIIKTSMEEAELIKYAANSFLAVKISFINEIANLCEKIPNCDINNIAKAIGMDKRISPYFLN
AGLGFGGSCFPKDTLAITSFAKDLGERLHIVEAAIEVNNERPFRAVKMMEDLIGKLENKSICILGIAFKPNTDDTRESVG
LKIAKLIREKGGKVIVYDPKAKADLEMVSLDECINKADGIIIATEWDEFRGLEDRLKGKYVVDGRRILNYKKLEKGRFKA
IGVS
>Mature_404_residues
MIIGIVGLGYVGLVTGAVLADQGHYVIGVDIDEKKVNGLNCNRIPIYEPGLDELIMKNKKKIQFTTNYSDLSDADIVFIA
VSTPTINGKIFLDYIYSAGENLQKILNKESVIVIKSTVIPGTSRKVKEITKREVIANPEFLREGSAIIDTKHPERIVIGG
DDEKAIKLIEDLWSFTNSPIIKTSMEEAELIKYAANSFLAVKISFINEIANLCEKIPNCDINNIAKAIGMDKRISPYFLN
AGLGFGGSCFPKDTLAITSFAKDLGERLHIVEAAIEVNNERPFRAVKMMEDLIGKLENKSICILGIAFKPNTDDTRESVG
LKIAKLIREKGGKVIVYDPKAKADLEMVSLDECINKADGIIIATEWDEFRGLEDRLKGKYVVDGRRILNYKKLEKGRFKA
IGVS

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=442, Percent_Identity=35.7466063348416, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI296040443, Length=428, Percent_Identity=32.9439252336449, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI296040438, Length=343, Percent_Identity=34.6938775510204, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1788340, Length=389, Percent_Identity=31.8766066838046, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI48994968, Length=418, Percent_Identity=27.2727272727273, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17560350, Length=459, Percent_Identity=33.9869281045752, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17136908, Length=453, Percent_Identity=33.112582781457, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 44734; Mature: 44734

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGIVGLGYVGLVTGAVLADQGHYVIGVDIDEKKVNGLNCNRIPIYEPGLDELIMKNKK
CEEEEEHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
KIQFTTNYSDLSDADIVFIAVSTPTINGKIFLDYIYSAGENLQKILNKESVIVIKSTVIP
EEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEEHHHCCHHHHHHHCCCCEEEEEEEECC
GTSRKVKEITKREVIANPEFLREGSAIIDTKHPERIVIGGDDEKAIKLIEDLWSFTNSPI
CCCHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCE
IKTSMEEAELIKYAANSFLAVKISFINEIANLCEKIPNCDINNIAKAIGMDKRISPYFLN
EEECHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEE
AGLGFGGSCFPKDTLAITSFAKDLGERLHIVEAAIEVNNERPFRAVKMMEDLIGKLENKS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCC
ICILGIAFKPNTDDTRESVGLKIAKLIREKGGKVIVYDPKAKADLEMVSLDECINKADGI
EEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEHHHHHHHCCCE
IIATEWDEFRGLEDRLKGKYVVDGRRILNYKKLEKGRFKAIGVS
EEEECCHHHCCHHHHHCCCEEECCHHHHCHHHHCCCCEEEECCC
>Mature Secondary Structure
MIIGIVGLGYVGLVTGAVLADQGHYVIGVDIDEKKVNGLNCNRIPIYEPGLDELIMKNKK
CEEEEEHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCC
KIQFTTNYSDLSDADIVFIAVSTPTINGKIFLDYIYSAGENLQKILNKESVIVIKSTVIP
EEEEEECCCCCCCCCEEEEEEECCCCCCEEEEEEHHHCCHHHHHHHCCCCEEEEEEEECC
GTSRKVKEITKREVIANPEFLREGSAIIDTKHPERIVIGGDDEKAIKLIEDLWSFTNSPI
CCCHHHHHHHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCE
IKTSMEEAELIKYAANSFLAVKISFINEIANLCEKIPNCDINNIAKAIGMDKRISPYFLN
EEECHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEE
AGLGFGGSCFPKDTLAITSFAKDLGERLHIVEAAIEVNNERPFRAVKMMEDLIGKLENKS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCC
ICILGIAFKPNTDDTRESVGLKIAKLIREKGGKVIVYDPKAKADLEMVSLDECINKADGI
EEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEHHHHHHHCCCE
IIATEWDEFRGLEDRLKGKYVVDGRRILNYKKLEKGRFKAIGVS
EEEECCHHHCCHHHHHCCCEEECCHHHHCHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]