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The map label for this gene is chb-1 [H]

Identifier: 227080794

GI number: 227080794

Start: 604322

End: 606235

Strand: Reverse

Name: chb-1 [H]

Synonym: VCM66_0571

Alternate gene names: 227080794

Gene position: 606235-604322 (Counterclockwise)

Preceding gene: 227080795

Following gene: 227080793

Centisome position: 20.96

GC content: 50.21

Gene sequence:

>1914_bases
ATGAGTTATCGAATTGAATTTGCGGTGCTCTCGGAACAAAAACCGGATTGCCGTTTTGGTTTAACCCTGCACAATTTGAG
CGATCAAGATCTGCATGATTGGTCGCTGTATTTTGTGATTGATCGTTACATCCAACCCATGAGTGTGACCAACGGTCAAC
TGACCCAAGTCGGCAGCTTATGTTCGATTGTTCCAACGGAAAAAGTGTTGCAAGCTAATGGCCACTTTTATTGTGAGTTC
ATCATCAAAACCGCGCCTTACCATTTCTACACCGATGGGGTAAAGCACGCGTTTGTCCAACTTAATGATAAACAGCCTGT
TGAACGTATTAACGTCGCGGTTAACCCTATCGTTCTCGCGTCACCATTTCGCGAGCGTAGCCAGATCCCTGAAGTGACTG
CGGCTGAGCTCTGTCTCATCCCCAAACCTAACTCACTGCAACGTTTCCAAGGTGAGTTTGTGGTCAACCACTCCAGCCAG
ATCTCGCTGCAATCGGACTCGGCCGCGCGTGCTGCACGCTGGTTAGAGCAAGAATTGCATGCACTGCATGAGTTCAAACT
GAATACGGTTGGCCATAGCGATATCGTCTACCGCAGTAATCCCACGCTCGATGAGGGCCATTACCAACTCAATATCGAAG
CGCAAGGGATCAAGATTGAAGCAGGCAGCCACAGTGGCTTTATGCATGCCAGCGCGACTTTGCTGCAACTGGCGCAAGCG
CATCAAGGCTCATTGCGCTTTCCTCTGGTCAACATTGTCGATGCACCGCGCTTTAAGTATCGCGGTATGATGCTCGATTG
CGCCCGCCATTTTCACTCGCTTGAGCAGGTCAAACGAGTGATCAATCAACTGGCACACTACAAATTTAACGTGTTCCACT
GGCATCTGACTGATGATGAAGGTTGGCGTATTGAGATTAAACGCCTGCCGCAACTGACAGACATTGGTGCATGGCGTGGC
ATGGATGAAGTGCTGGAACCTCAGTACAGCTTACTCACGGAGCGTCATGGCGGTTTCTATACCCAAGATGAGATCCGTGC
AGTGATTGAGTACGCCAGCGATCGTGGCATTACTGTCATCCCTGAAATTGACGTACCAGGGCACAGCCGCGCCGCGATTA
AAGCGCTGCCGGCATGGCTGGTCGATGAGGAAGATTGCTCGCAATATCGCAGTATTCAGTACTACAACGACAACGTGCTC
TCCCCTGCACTGCCGGGCACTTATCAATTCCTCGACATCGTATTGGAAGAAGTGGCTGCGCTGTTTCCAAGCCAATTTAT
TCATATCGGTGCCGATGAAGTCCCACACGGTGTGTGGGTAGATAGCCCGAAATGCCAAGCCTTAATGCAAGAGCAAGGCT
ATACCGACCCGAAAGAGCTGCAAGGCCACTTACTGCGCTACGCCGAGAAAAAACTCAAGAGCTTGGGTAAGCGTATGGTC
GGCTGGGAAGAAGCTCATCACGGCGACAAAGTGAGTAAAGATACGGTGATTTACTCTTGGCTATCGGAAAAAGCCGCCTT
GGATTGCGCCAAACAAGGCTTTGACGTGATTTTGCAGCCGGGACAATTTACCTATCTCGATATCGTTCAAGACTACGCTC
CTGAAGAACCGGGCGTGGATTGGGCGGGTGTTACTCCGCTAGAGCGTGCTTACGGTTATGAACCGTTAGCCGACGTTCCG
GCCAATGACCCACTGCGTAAACGCATTTTAGGTATTCAATGCGCCTTGTGGTGTGAATTGATCAATAACTCAGAACGCAT
GGAATACATGCTCTATCCACGTCTCACGGCATTAGCAGAAGGCGGTTGGACAGAGAAATCCCAGCGTGACTGGTTGGATT
ATCTAGCGCGTTTGAAAGGCCATTTACCACTGCTGGATAAGCAGAAAATACCTTATCGCGCGCCTTGGAAGTAA

Upstream 100 bases:

>100_bases
CACCGGTACAGCAGTGGATTGTCAAACCGCAATCGGATGCTATCGAAGGTGCATTAATGTTTGCCGGTAAGCCTGAGCAC
AACCTGTATAAGGATGGTTT

Downstream 100 bases:

>100_bases
TTCTGCCTTGAAAGTAATTCTTCCGGAAATCGTAACGACGGCGTGACGGAACTCACGCTGGTTTTCACTAGCAAAATTTT
TAGCTGCCATAGGGCAGCTG

Product: beta-N-acetylhexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MSYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSLCSIVPTEKVLQANGHFYCEF
IIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLASPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQ
ISLQSDSAARAARWLEQELHALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQA
HQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDEGWRIEIKRLPQLTDIGAWRG
MDEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVIPEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVL
SPALPGTYQFLDIVLEEVAALFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMV
GWEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVDWAGVTPLERAYGYEPLADVP
ANDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAEGGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK

Sequences:

>Translated_637_residues
MSYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSLCSIVPTEKVLQANGHFYCEF
IIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLASPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQ
ISLQSDSAARAARWLEQELHALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQA
HQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDEGWRIEIKRLPQLTDIGAWRG
MDEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVIPEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVL
SPALPGTYQFLDIVLEEVAALFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMV
GWEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVDWAGVTPLERAYGYEPLADVP
ANDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAEGGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK
>Mature_636_residues
SYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSLCSIVPTEKVLQANGHFYCEFI
IKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLASPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQI
SLQSDSAARAARWLEQELHALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQAH
QGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDEGWRIEIKRLPQLTDIGAWRGM
DEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVIPEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVLS
PALPGTYQFLDIVLEEVAALFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMVG
WEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVDWAGVTPLERAYGYEPLADVPA
NDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAEGGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI4504373, Length=428, Percent_Identity=29.4392523364486, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI189181666, Length=420, Percent_Identity=28.3333333333333, Blast_Score=161, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17569815, Length=422, Percent_Identity=28.1990521327014, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45551090, Length=431, Percent_Identity=28.0742459396752, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24653074, Length=431, Percent_Identity=28.0742459396752, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI281365639, Length=471, Percent_Identity=25.6900212314225, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24657474, Length=471, Percent_Identity=25.6900212314225, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24657468, Length=471, Percent_Identity=25.6900212314225, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17647501, Length=471, Percent_Identity=25.6900212314225, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17933586, Length=451, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 72764; Mature: 72633

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSL
CCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHEEEEHHHCCCCCCCCCCHHHHHHH
CSIVPTEKVLQANGHFYCEFIIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLA
HHCCCCHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEEEECCCCCHHHHHEEECCEEEE
SPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQISLQSDSAARAARWLEQELH
CCCHHHHCCCCCCHHCEEECCCCCHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHHHH
ALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQA
HHHHHHCCCCCCCCEEECCCCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHH
HQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDE
CCCCCCCCCCEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCC
GWRIEIKRLPQLTDIGAWRGMDEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVI
CCEEEEEECCCHHCCHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
PEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVLSPALPGTYQFLDIVLEEVAA
ECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMV
HCCHHEEECCCCCCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GWEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVD
CCHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCEEHHHHHHHHCCCCCCCC
WAGVTPLERAYGYEPLADVPANDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAE
CCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHC
GGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSL
CEEEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHEEEEHHHCCCCCCCCCCHHHHHHH
CSIVPTEKVLQANGHFYCEFIIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLA
HHCCCCHHHHHCCCCEEEEEEEECCCCEEECCCCEEEEEEECCCCCHHHHHEEECCEEEE
SPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQISLQSDSAARAARWLEQELH
CCCHHHHCCCCCCHHCEEECCCCCHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHHHH
ALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQA
HHHHHHCCCCCCCCEEECCCCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHH
HQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDE
CCCCCCCCCCEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCC
GWRIEIKRLPQLTDIGAWRGMDEVLEPQYSLLTERHGGFYTQDEIRAVIEYASDRGITVI
CCEEEEEECCCHHCCHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
PEIDVPGHSRAAIKALPAWLVDEEDCSQYRSIQYYNDNVLSPALPGTYQFLDIVLEEVAA
ECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LFPSQFIHIGADEVPHGVWVDSPKCQALMQEQGYTDPKELQGHLLRYAEKKLKSLGKRMV
HCCHHEEECCCCCCCCCEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GWEEAHHGDKVSKDTVIYSWLSEKAALDCAKQGFDVILQPGQFTYLDIVQDYAPEEPGVD
CCHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEECCCCEEHHHHHHHHCCCCCCCC
WAGVTPLERAYGYEPLADVPANDPLRKRILGIQCALWCELINNSERMEYMLYPRLTALAE
CCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHC
GGWTEKSQRDWLDYLARLKGHLPLLDKQKIPYRAPWK
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]