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The map label for this gene is can [H]

Identifier: 227080769

GI number: 227080769

Start: 571527

End: 572195

Strand: Reverse

Name: can [H]

Synonym: VCM66_0544

Alternate gene names: 227080769

Gene position: 572195-571527 (Counterclockwise)

Preceding gene: 227080774

Following gene: 227080767

Centisome position: 19.78

GC content: 46.79

Gene sequence:

>669_bases
ATGCCAGAAATTAAACAACTTTTTGAGAACAACTCAAAATGGTCTGAATCGATCAAAGCAGAAACTCCGGAATATTTTGC
CAAACTCGCTAAAGGGCAAAACCCGGATTTTTTGTGGATAGGATGTGCAGACAGCCGAGTGCCAGCCGAACGGCTCACTG
GCCTTTACTCGGGGGAATTATTTGTCCACCGTAACGTTGCCAATCAAGTTATCCATACCGATCTCAACTGTCTTTCTGTC
GTTCAGTATGCGGTCGATGTGCTGCAAGTCAAACACATCATTGTGTGCGGCCACTATGGGTGTGGTGGGGTTACTGCGGC
GATCGATAATCCACAACTTGGCTTAATCAATAACTGGTTGCTGCATATTCGCGATTACTACCTTAAACATCGTGAATATC
TCGATCAGATGCCTGCCGAAGATCGCTCCGATAAACTGGCAGAAATCAATGTCGCCGAGCAAGTCTACAACTTGGCTAAC
TCAACCGTGTTACAGAATGCTTGGGAGCGTGGACAAGCAGTAGAAGTACACGGTTTTGTCTACGGTATCGAGGATGGCCG
ACTGGAATATCTCGGTGTACGCTGCGCGTCACGCAGTGCAGTGGAAGATAATTACCACAAAGCGTTAGAGAAGATACTCA
ATCCGAATCATCGCCTACTGTGTCGTTAA

Upstream 100 bases:

>100_bases
GTTGTAAAAACACGTCAGATGAGTTAAGCAGAAAGTAAATTAGATGAGCTTGAATTTGTAACATTGTGTATATTGTTGGC
AATTATTTAAGGGAAGTAAG

Downstream 100 bases:

>100_bases
TTCTCTCCAAAGAGCAACGCCCACGAGTGCGTGGGCGTTGTCGGCAATCTTTTATTGTCAATCGTGAGCTTAGGTTATTC
CGCCAAAGGCACCACTTTGC

Product: putative carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase 2 [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MPEIKQLFENNSKWSESIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAERLTGLYSGELFVHRNVANQVIHTDLNCLSV
VQYAVDVLQVKHIIVCGHYGCGGVTAAIDNPQLGLINNWLLHIRDYYLKHREYLDQMPAEDRSDKLAEINVAEQVYNLAN
STVLQNAWERGQAVEVHGFVYGIEDGRLEYLGVRCASRSAVEDNYHKALEKILNPNHRLLCR

Sequences:

>Translated_222_residues
MPEIKQLFENNSKWSESIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAERLTGLYSGELFVHRNVANQVIHTDLNCLSV
VQYAVDVLQVKHIIVCGHYGCGGVTAAIDNPQLGLINNWLLHIRDYYLKHREYLDQMPAEDRSDKLAEINVAEQVYNLAN
STVLQNAWERGQAVEVHGFVYGIEDGRLEYLGVRCASRSAVEDNYHKALEKILNPNHRLLCR
>Mature_221_residues
PEIKQLFENNSKWSESIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAERLTGLYSGELFVHRNVANQVIHTDLNCLSVV
QYAVDVLQVKHIIVCGHYGCGGVTAAIDNPQLGLINNWLLHIRDYYLKHREYLDQMPAEDRSDKLAEINVAEQVYNLANS
TVLQNAWERGQAVEVHGFVYGIEDGRLEYLGVRCASRSAVEDNYHKALEKILNPNHRLLCR

Specific function: Unknown

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786318, Length=220, Percent_Identity=61.8181818181818, Blast_Score=290, Evalue=8e-80,
Organism=Escherichia coli, GI1786534, Length=195, Percent_Identity=32.3076923076923, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324292, Length=199, Percent_Identity=29.6482412060301, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25225; Mature: 25094

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIKQLFENNSKWSESIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAERLTGLYSGEL
CCHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEE
FVHRNVANQVIHTDLNCLSVVQYAVDVLQVKHIIVCGHYGCGGVTAAIDNPQLGLINNWL
EEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHH
LHIRDYYLKHREYLDQMPAEDRSDKLAEINVAEQVYNLANSTVLQNAWERGQAVEVHGFV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
YGIEDGRLEYLGVRCASRSAVEDNYHKALEKILNPNHRLLCR
EECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECC
>Mature Secondary Structure 
PEIKQLFENNSKWSESIKAETPEYFAKLAKGQNPDFLWIGCADSRVPAERLTGLYSGEL
CHHHHHHCCCCHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEE
FVHRNVANQVIHTDLNCLSVVQYAVDVLQVKHIIVCGHYGCGGVTAAIDNPQLGLINNWL
EEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCHHHHHH
LHIRDYYLKHREYLDQMPAEDRSDKLAEINVAEQVYNLANSTVLQNAWERGQAVEVHGFV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
YGIEDGRLEYLGVRCASRSAVEDNYHKALEKILNPNHRLLCR
EECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8202364; 9278503; 10493123 [H]