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The map label for this gene is panC

Identifier: 227080774

GI number: 227080774

Start: 576130

End: 577011

Strand: Reverse

Name: panC

Synonym: VCM66_0549

Alternate gene names: 227080774

Gene position: 577011-576130 (Counterclockwise)

Preceding gene: 227080775

Following gene: 227080769

Centisome position: 19.95

GC content: 49.89

Gene sequence:

>882_bases
ATGCAAGTTTTTGCTGACATCGCCGTTCTTCGCGAGCAGATCAAACAGATCAAGCGCGAAGGTCGCCGCGTCGCTTTTGT
ACCGACCATGGGTAATTTACACGAAGGCCATTTAACCCTGGTTCGTAAAGCTCGTGAGCTCGCTGACGTCGTCGTGGTGA
GTATTTTCGTCAATCCGATGCAGTTTGATCGCGCAGAAGATTTGAAAAATTACCCACGTACGCTTGAAGAAGACCTAAGC
AAACTCAACGGCGAAGGGGTTGATCTGGTTTTAACGCCGACACCCGAAACCATGTACCCACAAGGGTTGGATAAGCAGAC
CTTTGTTGAAGTGCCAGGGCTCTCTTACATGCTCGAAGGCGCATCGCGTCCGGGACATTTCCGTGGCGTCGCGACCATTG
TCACTAAACTGTTTAATATTGTGCAGCCAGATGTCGCTTGCTTTGGCGAAAAAGATTTCCAGCAATTGGCGGTGATCCGT
CAAATGGTAGAAGACTTGTGCATGGATATTGAGATTGTAGGCGTAGCGACCGTACGTGAGTTAGATGGCCTTGCCATGAG
TTCACGTAATAATTTGCTGACGCTGGATGAGCGCCAACGTGCGCCCGTTTTGGCGCGCACTATGCGCTGGATCAGTAGCG
CCATTCGTGGTGGTCGCGATGATTATCCATCAATCATTGAAGATGCAGTGGATCAGTTGCGTGCGGCCGATTTAGAGCCA
GATGAAATCTTCATCCGTGATGCACGCACTCTGCTACCTATCAGCAGTGAGAGTAAGCAAGCCGTGATCCTGATGTCCGC
TTTCCTCGGTAAAGTGCGTTTGATTGATAACCAAGTTCTCGATCTGCAAACCGACACCAAAGCCAGTAGCGAAGAAGAAT
AA

Upstream 100 bases:

>100_bases
GAGACTGGCGATATTCGCCAAGCCGTTGCCAAATATATCGAAGATGTTGCCAGTGGCGCGTTTCCCGATCTCGCCCACAC
CATTGCCTAAGGAGTCATAC

Downstream 100 bases:

>100_bases
TCCTCTTGTCTCTGGATCAAAAAAGGTCAACCTCGGTTGACCTTTTCTATATCGATTGTCTGATTAGCTGCGCAGCCCTT
TGCCTTTGGTCACTAAATAA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MQVFADIAVLREQIKQIKREGRRVAFVPTMGNLHEGHLTLVRKARELADVVVVSIFVNPMQFDRAEDLKNYPRTLEEDLS
KLNGEGVDLVLTPTPETMYPQGLDKQTFVEVPGLSYMLEGASRPGHFRGVATIVTKLFNIVQPDVACFGEKDFQQLAVIR
QMVEDLCMDIEIVGVATVRELDGLAMSSRNNLLTLDERQRAPVLARTMRWISSAIRGGRDDYPSIIEDAVDQLRAADLEP
DEIFIRDARTLLPISSESKQAVILMSAFLGKVRLIDNQVLDLQTDTKASSEEE

Sequences:

>Translated_293_residues
MQVFADIAVLREQIKQIKREGRRVAFVPTMGNLHEGHLTLVRKARELADVVVVSIFVNPMQFDRAEDLKNYPRTLEEDLS
KLNGEGVDLVLTPTPETMYPQGLDKQTFVEVPGLSYMLEGASRPGHFRGVATIVTKLFNIVQPDVACFGEKDFQQLAVIR
QMVEDLCMDIEIVGVATVRELDGLAMSSRNNLLTLDERQRAPVLARTMRWISSAIRGGRDDYPSIIEDAVDQLRAADLEP
DEIFIRDARTLLPISSESKQAVILMSAFLGKVRLIDNQVLDLQTDTKASSEEE
>Mature_293_residues
MQVFADIAVLREQIKQIKREGRRVAFVPTMGNLHEGHLTLVRKARELADVVVVSIFVNPMQFDRAEDLKNYPRTLEEDLS
KLNGEGVDLVLTPTPETMYPQGLDKQTFVEVPGLSYMLEGASRPGHFRGVATIVTKLFNIVQPDVACFGEKDFQQLAVIR
QMVEDLCMDIEIVGVATVRELDGLAMSSRNNLLTLDERQRAPVLARTMRWISSAIRGGRDDYPSIIEDAVDQLRAADLEP
DEIFIRDARTLLPISSESKQAVILMSAFLGKVRLIDNQVLDLQTDTKASSEEE

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=58.1560283687943, Blast_Score=334, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6322046, Length=310, Percent_Identity=40.6451612903226, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_VIBC3 (A5F974)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F974
- SMR:   A5F974
- STRING:   A5F974
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0122
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- ProtClustDB:   PRK00380
- BioCyc:   VCHO345073:VC0395_A0122-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32855; Mature: 32855

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVFADIAVLREQIKQIKREGRRVAFVPTMGNLHEGHLTLVRKARELADVVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
QFDRAEDLKNYPRTLEEDLSKLNGEGVDLVLTPTPETMYPQGLDKQTFVEVPGLSYMLEG
HHCCHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVATIVTKLFNIVQPDVACFGEKDFQQLAVIRQMVEDLCMDIEIVGVATVRE
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHH
LDGLAMSSRNNLLTLDERQRAPVLARTMRWISSAIRGGRDDYPSIIEDAVDQLRAADLEP
HHCHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
DEIFIRDARTLLPISSESKQAVILMSAFLGKVRLIDNQVLDLQTDTKASSEEE
HHEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MQVFADIAVLREQIKQIKREGRRVAFVPTMGNLHEGHLTLVRKARELADVVVVSIFVNPM
CCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
QFDRAEDLKNYPRTLEEDLSKLNGEGVDLVLTPTPETMYPQGLDKQTFVEVPGLSYMLEG
HHCCHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHC
ASRPGHFRGVATIVTKLFNIVQPDVACFGEKDFQQLAVIRQMVEDLCMDIEIVGVATVRE
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHH
LDGLAMSSRNNLLTLDERQRAPVLARTMRWISSAIRGGRDDYPSIIEDAVDQLRAADLEP
HHCHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
DEIFIRDARTLLPISSESKQAVILMSAFLGKVRLIDNQVLDLQTDTKASSEEE
HHEEEECCHHEECCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA