Click here to switch to the map view.

The map label for this gene is hgdC [H]

Identifier: 226950623

GI number: 226950623

Start: 3644625

End: 3645599

Strand: Direct

Name: hgdC [H]

Synonym: CLM_3607

Alternate gene names: 226950623

Gene position: 3644625-3645599 (Clockwise)

Preceding gene: 226950622

Following gene: 226950639

Centisome position: 87.71

GC content: 30.46

Gene sequence:

>975_bases
ATGTATTATATGGGAGTTGATATAGGTTCTGTAAGTACAGATATTGTAATTATTGATGAAAATTCAAATGTTATTGATTC
TTTGTATTTAAGAACCAAAGGAAATCCTATAAAAACTATACAAGAAGGATTTAAAATATTAAGTAATAAATATGATAGCA
AACAAATAGGTGCTGTAGGTACTACTGGTAGTGGAAGAATTATAGGTTCTTATTTAATAGGTGCTGATGCAGTAAAAAAT
GAAATAACTGCTCATGCCATAGCTTCCTTAAATTTAGATAAGAATGTTAAAACAATAATAGAAATAGGTGGCCAAGATTC
TAAAATAATACTTCTAAGAAATGGGGTAGTTACAGATTTCGCCATGAATACGGTATGTGCCGCTGGAACAGGCTCCTTTT
TAGACAGACAGGCAGAAAGATTAGGTATACCCATAGAAAATTTAGGTGATTATTCCTTAAAAGCAACTTCTTCTGTAAGA
ATCGCTGGAAGGTGTGCAGTTTTTGCTGAATCAGATATGATACATAAACAACAGCTAGGTTGTACTCGAGAAAGCATAAT
AAGAGGCCTTTGTGATGCACTAGTTAGAAATTATTTAAACAATGTTGGAAAAGGTAAGGAAATTCTACCTAAAATATTTT
TTCAAGGCGGTGTAGCTGCTAACGAAGGAATTAAAGATTCCTTTGAAAGAGCTTTAGGTTATGAAATAATTGTACCTAAA
TATCACAAAATAATGGGATCTATCGGTGTAGCTTTAATAGCGAAAAATAATCTAAAAAAATCAAATTCTATTACAAGTTT
TAGAGGATTCGACATATATGATAAAGATTTTATTTCTAAAACTTTTGAATGTAATGGCTGTGCCAATGCGTGTGAAGTAG
TAAAAATATTAGATAATAATATTATATTAGGTTCTTTTGGTGATAGATGTGGTAAATGGAGTAATACCTTAGAATATAGA
AAAACATCTTCTTAA

Upstream 100 bases:

>100_bases
TTCCCTATTATGTCCCTTGTGGTAGATGAAATGACAGGAGAAGCAGGATATTCAACTCGCATAGAAGCTTTTATAGATTT
ATTAGAAAGGAGAGAAGACA

Downstream 100 bases:

>100_bases
AAAATAAAATAAAAAACAACAGATCCATTATTAAGTGCTCTGTTGTTTTTATATTTTATCAAGTTAAACTATATTATATT
CTGATATTTTCTTATACAAA

Product: putative CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MYYMGVDIGSVSTDIVIIDENSNVIDSLYLRTKGNPIKTIQEGFKILSNKYDSKQIGAVGTTGSGRIIGSYLIGADAVKN
EITAHAIASLNLDKNVKTIIEIGGQDSKIILLRNGVVTDFAMNTVCAAGTGSFLDRQAERLGIPIENLGDYSLKATSSVR
IAGRCAVFAESDMIHKQQLGCTRESIIRGLCDALVRNYLNNVGKGKEILPKIFFQGGVAANEGIKDSFERALGYEIIVPK
YHKIMGSIGVALIAKNNLKKSNSITSFRGFDIYDKDFISKTFECNGCANACEVVKILDNNIILGSFGDRCGKWSNTLEYR
KTSS

Sequences:

>Translated_324_residues
MYYMGVDIGSVSTDIVIIDENSNVIDSLYLRTKGNPIKTIQEGFKILSNKYDSKQIGAVGTTGSGRIIGSYLIGADAVKN
EITAHAIASLNLDKNVKTIIEIGGQDSKIILLRNGVVTDFAMNTVCAAGTGSFLDRQAERLGIPIENLGDYSLKATSSVR
IAGRCAVFAESDMIHKQQLGCTRESIIRGLCDALVRNYLNNVGKGKEILPKIFFQGGVAANEGIKDSFERALGYEIIVPK
YHKIMGSIGVALIAKNNLKKSNSITSFRGFDIYDKDFISKTFECNGCANACEVVKILDNNIILGSFGDRCGKWSNTLEYR
KTSS
>Mature_324_residues
MYYMGVDIGSVSTDIVIIDENSNVIDSLYLRTKGNPIKTIQEGFKILSNKYDSKQIGAVGTTGSGRIIGSYLIGADAVKN
EITAHAIASLNLDKNVKTIIEIGGQDSKIILLRNGVVTDFAMNTVCAAGTGSFLDRQAERLGIPIENLGDYSLKATSSVR
IAGRCAVFAESDMIHKQQLGCTRESIIRGLCDALVRNYLNNVGKGKEILPKIFFQGGVAANEGIKDSFERALGYEIIVPK
YHKIMGSIGVALIAKNNLKKSNSITSFRGFDIYDKDFISKTFECNGCANACEVVKILDNNIILGSFGDRCGKWSNTLEYR
KTSS

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=257, Percent_Identity=31.1284046692607, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 35196; Mature: 35196

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYMGVDIGSVSTDIVIIDENSNVIDSLYLRTKGNPIKTIQEGFKILSNKYDSKQIGAVG
CEEEEEECCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
TTGSGRIIGSYLIGADAVKNEITAHAIASLNLDKNVKTIIEIGGQDSKIILLRNGVVTDF
CCCCCCEEEHHHHCCHHHHHHHHHHHHEECCCCCCCEEHEEECCCCCEEEEEECCCCHHH
AMNTVCAAGTGSFLDRQAERLGIPIENLGDYSLKATSSVRIAGRCAVFAESDMIHKQQLG
HHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCEEECCCEEEEEEEEEEEECCCHHHHHHHC
CTRESIIRGLCDALVRNYLNNVGKGKEILPKIFFQGGVAANEGIKDSFERALGYEIIVPK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCH
YHKIMGSIGVALIAKNNLKKSNSITSFRGFDIYDKDFISKTFECNGCANACEVVKILDNN
HHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCC
IILGSFGDRCGKWSNTLEYRKTSS
EEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYYMGVDIGSVSTDIVIIDENSNVIDSLYLRTKGNPIKTIQEGFKILSNKYDSKQIGAVG
CEEEEEECCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCC
TTGSGRIIGSYLIGADAVKNEITAHAIASLNLDKNVKTIIEIGGQDSKIILLRNGVVTDF
CCCCCCEEEHHHHCCHHHHHHHHHHHHEECCCCCCCEEHEEECCCCCEEEEEECCCCHHH
AMNTVCAAGTGSFLDRQAERLGIPIENLGDYSLKATSSVRIAGRCAVFAESDMIHKQQLG
HHHHHHCCCCCHHHHHHHHHHCCCHHHCCCCEEECCCEEEEEEEEEEEECCCHHHHHHHC
CTRESIIRGLCDALVRNYLNNVGKGKEILPKIFFQGGVAANEGIKDSFERALGYEIIVPK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEECCH
YHKIMGSIGVALIAKNNLKKSNSITSFRGFDIYDKDFISKTFECNGCANACEVVKILDNN
HHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCC
IILGSFGDRCGKWSNTLEYRKTSS
EEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]