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The map label for this gene is pgcA [H]

Identifier: 226950545

GI number: 226950545

Start: 3552006

End: 3553733

Strand: Reverse

Name: pgcA [H]

Synonym: CLM_3521

Alternate gene names: 226950545

Gene position: 3553733-3552006 (Counterclockwise)

Preceding gene: 226950546

Following gene: 226950544

Centisome position: 85.52

GC content: 25.75

Gene sequence:

>1728_bases
ATGAACTATAAATATGCTTACAATTCATGGATGAATTCTTGTTTTTTAGAAGAAAGAGAAAAAGAACAATTAAAAAACAT
AGATGATGAACAAGAGATAAAAGACAGATTCTATAAAGATTTAAGCTTTGGAACAGGTGGAATAAGAGGGGTAGTTGGTT
TAGGTACAAATAGAATAAATAAATATACTATAGCTAAAGCTACAGAAGGGTTATCAAATTATCTAATTCATAATTTTAAA
CAAAAAGTTATATCTGTTGCAATAGCCTATGATTGTAGAAATGATTCTTTAGATTTCGCTAAAAAAGCTAGTGAAGTATT
ATGTTCACATGGTATAAGAGTATATATATTTAGTGATATAATGTGCACACCTATACTATCCTATGCTGTTAGAGAACTAA
AATGTAAAGCTGGAATAGTTATAACTGCATCACATAATAGTAAAGAGTATAATGGGTACAAAGTATATAATCATAATGGA
AATCAAGTAACAGATAAAGAAGCACAAGAGATAGCTGAGTATATAAAAGAAGTAGAGGACTTAGGTTGTATAAAGTATAT
GGATATAAACGATGCAAAGGGAAAAAATTTATACGAATTTGTACCAATAGAGATATTAAATAAATATTTTTATAATGTAA
AAAATTTAACTTTAAGAAAAGATATTGTAAAAAATTATGAAAAGGATTTTAAAATATTATATACACCACTACATGGAACT
GGAAATGTTCCAGTGAGAAGAGCTTTATGTGAAATTGGATATAATAATGTTTTTGTAGTTAAGGATCAAGAAAAACCTAA
TGGAAATTTCCCAACAGTAAAATATCCTAATCCAGAGGATAATAAAGCTTTCTATGCTTCTTTAAAAGAGGCAGAAAATA
TAAATCCTGATGTAATAATAGCTACCGATCCCGATTGTGATAGAGTAGGGATTATGGTTAGGGATCATAGTACAAGATAT
GTAGCTTTAAATGGAAATGAATTAGGTGTAATTCTTACTAATTATATATTAAGTTCCTTAGAAGAAGAAAAAAAAATACC
TGAAAATTCAGTGCTTTTAAAAACCATAGTAACTACAGATATGGTTAAAAGTATATGTAAAGACTATGGAGTTAAGGTAG
AAGAAGTTTTAACAGGTTTTAAATATATAGGAGAGAAAATAGAAGAATTTAAGAAAAATGGACAAAATAAATTTATATTT
GGATTTGAGGAAAGCTATGGATATTTATTTGGAGACTTTGTTAGGGAGAAGGACGGAATAATAAGTTCCGCATTAATATG
TGAAATGGCTTTATATTATAAGAGTCAAAATAAAAATTTATTTGATGTTTTAACAGAACTTTATGATAAATATGGATATT
ACAAGGAAAAATTAATATCCATGGAGTTTAAAGGAGAAGAGGGCAAAAATAAAATAGAAAATATAATCAATAATTTAAGA
ATTCATGATTCTAAAACTATATTTAATGAAGAAATACTACTAAAAGAAGACTATAAAACAGGTTTGAAAATAAATATTAA
TAAAAAGAAAGAATATATTAATAAACTTCCTAAATCTAATGTTATAAAATTTCATTTAAATAACGGTACTAATTTTGTAA
TTAGACCATCTGGAACAGAACCTAAAATAAAAATATATTTATCATCAGTACACACAACAGCTGAAGGAGCTGAAATGAAT
ATAAATAAGCTAGAAAAAAATATAAAGAATATGATAAATAAATTTTAA

Upstream 100 bases:

>100_bases
TCAACCTTTAAAGACTGTTAAGTCATAATTTCCTTAAATTTAGTACAATTATTTAGGTTTTTTAATATAATGTAGTATGA
AATTTTATTGGAGGTAGTAA

Downstream 100 bases:

>100_bases
AACTACAAATATTTAAATTATGCATAGGATAACTTTAAAAATTATCCTATGCATAATTTAAATATTTTTGTATTTTCATT
GTTTAATCATTTATATTATT

Product: phosphoglucomutase/phosphomannomutase family protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGVVGLGTNRINKYTIAKATEGLSNYLIHNFK
QKVISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQVTDKEAQEIAEYIKEVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKSICKDYGVKVEEVLTGFKYIGEKIEEFKKNGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKLPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF

Sequences:

>Translated_575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGVVGLGTNRINKYTIAKATEGLSNYLIHNFK
QKVISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQVTDKEAQEIAEYIKEVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKSICKDYGVKVEEVLTGFKYIGEKIEEFKKNGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKLPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF
>Mature_575_residues
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGVVGLGTNRINKYTIAKATEGLSNYLIHNFK
QKVISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDIMCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNG
NQVTDKEAQEIAEYIKEVEDLGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVIIATDPDCDRVGIMVRDHSTRY
VALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTDMVKSICKDYGVKVEEVLTGFKYIGEKIEEFKKNGQNKFIF
GFEESYGYLFGDFVREKDGIISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKLPKSNVIKFHLNNGTNFVIRPSGTEPKIKIYLSSVHTTAEGAEMN
INKLEKNIKNMINKF

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=584, Percent_Identity=32.5342465753425, Blast_Score=276, Evalue=5e-74,
Organism=Homo sapiens, GI63055049, Length=569, Percent_Identity=31.2829525483304, Blast_Score=274, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71993870, Length=559, Percent_Identity=31.6636851520572, Blast_Score=274, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71993878, Length=311, Percent_Identity=34.4051446945338, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323934, Length=582, Percent_Identity=29.0378006872852, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI20129809, Length=562, Percent_Identity=28.1138790035587, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24653722, Length=535, Percent_Identity=28.5981308411215, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24651977, Length=520, Percent_Identity=28.2692307692308, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 66198; Mature: 66198

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGVVGLGTNRIN
CCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
KYTIAKATEGLSNYLIHNFKQKVISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDI
EEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHH
MCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNGNQVTDKEAQEIAEYIKEVED
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCC
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVII
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCEEE
ATDPDCDRVGIMVRDHSTRYVALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTD
EECCCCCEEEEEEEECCEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MVKSICKDYGVKVEEVLTGFKYIGEKIEEFKKNGQNKFIFGFEESYGYLFGDFVREKDGI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCH
ISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCE
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKLPKSNVIKFHLNNGTNFVIRPSGTE
ECCCCCEECCCEEEECCCCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC
PKIKIYLSSVHTTAEGAEMNINKLEKNIKNMINKF
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYKYAYNSWMNSCFLEEREKEQLKNIDDEQEIKDRFYKDLSFGTGGIRGVVGLGTNRIN
CCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCC
KYTIAKATEGLSNYLIHNFKQKVISVAIAYDCRNDSLDFAKKASEVLCSHGIRVYIFSDI
EEEEHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEHHH
MCTPILSYAVRELKCKAGIVITASHNSKEYNGYKVYNHNGNQVTDKEAQEIAEYIKEVED
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGCIKYMDINDAKGKNLYEFVPIEILNKYFYNVKNLTLRKDIVKNYEKDFKILYTPLHGT
CCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCC
GNVPVRRALCEIGYNNVFVVKDQEKPNGNFPTVKYPNPEDNKAFYASLKEAENINPDVII
CCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCEEE
ATDPDCDRVGIMVRDHSTRYVALNGNELGVILTNYILSSLEEEKKIPENSVLLKTIVTTD
EECCCCCEEEEEEEECCEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MVKSICKDYGVKVEEVLTGFKYIGEKIEEFKKNGQNKFIFGFEESYGYLFGDFVREKDGI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCH
ISSALICEMALYYKSQNKNLFDVLTELYDKYGYYKEKLISMEFKGEEGKNKIENIINNLR
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHEEEEECCCCCHHHHHHHHHHCE
IHDSKTIFNEEILLKEDYKTGLKININKKKEYINKLPKSNVIKFHLNNGTNFVIRPSGTE
ECCCCCEECCCEEEECCCCCCCEEEECHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCC
PKIKIYLSSVHTTAEGAEMNINKLEKNIKNMINKF
CEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]