| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
Click here to switch to the map view.
The map label for this gene is hisD [H]
Identifier: 226948898
GI number: 226948898
Start: 1839552
End: 1840856
Strand: Direct
Name: hisD [H]
Synonym: CLM_1808
Alternate gene names: 226948898
Gene position: 1839552-1840856 (Clockwise)
Preceding gene: 226948897
Following gene: 226948899
Centisome position: 44.27
GC content: 31.72
Gene sequence:
>1305_bases ATGATAAATATAGTTAAAATAGGTGAAGACAATAAAAAACAGTGCATAAATAATTTGAAAAGCAGGTCAAAAAAAGTACA AAAGGATGTAATTACTTCTGTAAAAAAAATACTAGAGGACATAAACGGAAATGGGGATAAAGCATTAATAAAATATACTA ATAAATTTGATAGTAAAAAAATAAATTTAGAAAATATTAGAGTTACTTCAGAAGAGATAAAAAAGGCTTATGAATTAGTT GATGAAAAATTTATAAAGGCTATAAAAATTGCTAAAGAAAATATATTGTTTTATCATGAGAAGCAAAAACAAAGATCATG GATGGTAACAAAGGAAGATGGAATAATTTTAGGTCAGCAAATTAGAGCTCTAGAAACTGTAGGTATATACGTTCCAGGAG GAACAGCAGCTTATCCTTCTTCAGTATTAATGAACACCCTTCCAGCTAAAGTAGCAGGAGTAGAAAAAATAGTTATGATA ACTCCTCCTTCTAAGGATGGGAGTGTAAATCCTAATATTTTAGTAGCTGCTAATATTGCAGGAGTTGATGAAATATACAA AGCAGGAGGAGCACAAGGAATAGGAGCTTTAGCTTATGGAACAGAAATCATACCAAAGGTGGATAAAATAGTAGGTCCAG GTAATATATATGTGGCTATGGCCAAAAGAAGTGTTTATGGTTTTGTGGATATAGATATGATAGCAGGGCCTAGTGAAATT TTGATTATAGCAGATGAAAGTTCTGATCCTAAATTTATAGCAGCAGATTTTATGTCTCAAGCTGAGCATGATGTATTGGC ATCCTCAATGTTAGTTACTACCTCTAAGAGATTAGCTGAAAAGGTAATAAAGCAATTAAATATACAGATAAAAAATCTTT CAAGGAAAGAAATAATACGTACATCTATTAAAGATTATGGTGCTATTTTTGTAGTAGATAATTTAGAAGAAGCTATAGAA CTTGCTAATGATATATCCCCAGAACATTTAGAGGTTATGACAGAAGACCCCTTCACTATTTTAGGACAAATTAAAAATGC AGGTTCTGTATTCTTAGGTAAATATGCTCCAGAACCATTAGGGGATTATATGGCAGGACCAAATCATGTATTGCCTACTA GCGGAAGTGCAAGATTTTTTTCACCTCTTTCAGTAGATGATTATATTAAGAAATCAAGTTTCACATATTACACCAAAAGG GCATTGGAAAAAGTAAAGGATGTTACTGTAACCATGGCTGAAACAGAGGGATTAACTGCCCATGCAAATTCCATAAGAGT GAGATTTGATAACAATAATTTTTGA
Upstream 100 bases:
>100_bases TAAGTGAGGTAATAAGGCAATAAAAAAGAACAAAAATAGGAAAGGGGGGTATTTAGTGAGTTAATGTATTTTTTATATAC TCTCTCACTAAAGTTAAAAA
Downstream 100 bases:
>100_bases TTTTAGGAAGATGTTAAGTTTAAATTGAAGATTTAAAAGTGGTAATTAATAGATAAATAGTAGTTTAATATGTTTCCTAT AAAAATACAATTGGAACAGT
Product: histidinol dehydrogenase
Products: NA
Alternate protein names: HDH [H]
Number of amino acids: Translated: 434; Mature: 434
Protein sequence:
>434_residues MINIVKIGEDNKKQCINNLKSRSKKVQKDVITSVKKILEDINGNGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVPGGTAAYPSSVLMNTLPAKVAGVEKIVMI TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTEIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSKRLAEKVIKQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR ALEKVKDVTVTMAETEGLTAHANSIRVRFDNNNF
Sequences:
>Translated_434_residues MINIVKIGEDNKKQCINNLKSRSKKVQKDVITSVKKILEDINGNGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVPGGTAAYPSSVLMNTLPAKVAGVEKIVMI TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTEIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSKRLAEKVIKQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR ALEKVKDVTVTMAETEGLTAHANSIRVRFDNNNF >Mature_434_residues MINIVKIGEDNKKQCINNLKSRSKKVQKDVITSVKKILEDINGNGDKALIKYTNKFDSKKINLENIRVTSEEIKKAYELV DEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQIRALETVGIYVPGGTAAYPSSVLMNTLPAKVAGVEKIVMI TPPSKDGSVNPNILVAANIAGVDEIYKAGGAQGIGALAYGTEIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSKRLAEKVIKQLNIQIKNLSRKEIIRTSIKDYGAIFVVDNLEEAIE LANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPLGDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKR ALEKVKDVTVTMAETEGLTAHANSIRVRFDNNNF
Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]
COG id: COG0141
COG function: function code E; Histidinol dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the histidinol dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1788331, Length=406, Percent_Identity=38.1773399014778, Blast_Score=296, Evalue=2e-81, Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=37.914691943128, Blast_Score=281, Evalue=1e-76,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016161 - InterPro: IPR022695 - InterPro: IPR001692 - InterPro: IPR012131 [H]
Pfam domain/function: PF00815 Histidinol_dh [H]
EC number: =1.1.1.23 [H]
Molecular weight: Translated: 47769; Mature: 47769
Theoretical pI: Translated: 8.68; Mature: 8.68
Prosite motif: PS00611 HISOL_DEHYDROGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MINIVKIGEDNKKQCINNLKSRSKKVQKDVITSVKKILEDINGNGDKALIKYTNKFDSKK CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCE INLENIRVTSEEIKKAYELVDEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQ EEHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHCCCEEEECCCCEEEHHH IRALETVGIYVPGGTAAYPSSVLMNTLPAKVAGVEKIVMITPPSKDGSVNPNILVAANIA HHEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEECC GVDEIYKAGGAQGIGALAYGTEIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI CHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCEE LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSKRLAEKVIKQLNIQIKNLSRKEIIR EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHH TSIKDYGAIFVVDNLEEAIELANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPL HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEECCCCCEEHHHHCCCCCEEEECCCCCCH GDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKRALEKVKDVTVTMAETEGLTA HHHCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCEE HANSIRVRFDNNNF ECCEEEEEECCCCC >Mature Secondary Structure MINIVKIGEDNKKQCINNLKSRSKKVQKDVITSVKKILEDINGNGDKALIKYTNKFDSKK CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCE INLENIRVTSEEIKKAYELVDEKFIKAIKIAKENILFYHEKQKQRSWMVTKEDGIILGQQ EEHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHCCCEEEECCCCEEEHHH IRALETVGIYVPGGTAAYPSSVLMNTLPAKVAGVEKIVMITPPSKDGSVNPNILVAANIA HHEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEECC GVDEIYKAGGAQGIGALAYGTEIIPKVDKIVGPGNIYVAMAKRSVYGFVDIDMIAGPSEI CHHHHHHCCCCCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCEE LIIADESSDPKFIAADFMSQAEHDVLASSMLVTTSKRLAEKVIKQLNIQIKNLSRKEIIR EEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHH TSIKDYGAIFVVDNLEEAIELANDISPEHLEVMTEDPFTILGQIKNAGSVFLGKYAPEPL HHHHHCCEEEEECCHHHHHHHHHCCCCCCEEEECCCCCEEHHHHCCCCCEEEECCCCCCH GDYMAGPNHVLPTSGSARFFSPLSVDDYIKKSSFTYYTKRALEKVKDVTVTMAETEGLTA HHHCCCCCCCCCCCCCCCEECCCCHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCEE HANSIRVRFDNNNF ECCEEEEEECCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11466286 [H]