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The map label for this gene is hisG

Identifier: 226948897

GI number: 226948897

Start: 1838836

End: 1839474

Strand: Direct

Name: hisG

Synonym: CLM_1807

Alternate gene names: 226948897

Gene position: 1838836-1839474 (Clockwise)

Preceding gene: 226948896

Following gene: 226948898

Centisome position: 44.25

GC content: 30.05

Gene sequence:

>639_bases
TTGAAAAATGTAAAAATAGCGTTAACCAAAGGTAGACTTGAAAAGAAAGCTATTGAAATATTTAAAACTATTAATATTAA
TACTAGAGAATTAGAGGATAAAGGAAGAAAACTCATTTTTAATTGTGAAAATGAGGAATATAATATAGAGCTTTTTTTAG
TTAAAGCTAAAGATGTAGAAACCTATGTAGAATATGGAGCTGCGGATATCGGTATTGTAGGAAAAGATACTTTAATGGAA
ACAAATAAGGAGTTTTATGAAGTTTTAGATCTGAATGTAGGAAAGTGTAAATTTGCTTTAGCGGCTTTGCCTAGTTTTAA
GTTAGATCAAGGATATAATAGGAAAAAGATAGCAACTAAATATCCGAATATAGCAAGGGAATATTTTAGAAAAAAGGGCA
TGGATGTGGAATTAATCAAAATAGAAGGCTCCGTAGAATTAGGACCTATTGTAGGGCTTGCAGATGCCATAGTAGATATT
GTAGAAACAGGAAACACTTTAAGAGAAAATGGCTTAGTAGTTGTGGAGGATATATGTGAAATAAGTGCAAGAATGATAGT
AAATAAGGCCAGTATGAAAACGAAAAAGGATGAAATCATAAAAATAATTGAAAATGTAAGTGAGGTAATAAGGCAATAA

Upstream 100 bases:

>100_bases
ATTTGTTAAGGATTTAAAATCAGATAAAATAGCTTTTCTAAAGAAAGATGAGATTGAAAATTTGTTAATGTTGTAATTAA
TAAGGAAATGGGTGATTACA

Downstream 100 bases:

>100_bases
AAAAGAACAAAAATAGGAAAGGGGGGTATTTAGTGAGTTAATGTATTTTTTATATACTCTCTCACTAAAGTTAAAAAATG
ATAAATATAGTTAAAATAGG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDTLME
TNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDI
VETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ

Sequences:

>Translated_212_residues
MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDTLME
TNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDI
VETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
>Mature_212_residues
MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVETYVEYGAADIGIVGKDTLME
TNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATKYPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDI
VETGNTLRENGLVVVEDICEISARMIVNKASMKTKKDEIIKIIENVSEVIRQ

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=229, Percent_Identity=31.4410480349345, Blast_Score=97, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320896, Length=189, Percent_Identity=31.2169312169312, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CLOB1 (A7FU76)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001383909.1
- ProteinModelPortal:   A7FU76
- SMR:   A7FU76
- STRING:   A7FU76
- GeneID:   5396926
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1586
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   PRK01686
- BioCyc:   CBOT441770:CLB_1586-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24011; Mature: 24011

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVE
CCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEEEEEEEECCCHH
TYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATK
HHHHHCCCCEEECCCHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHC
YPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVEDICE
CCHHHHHHHHHCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCCHHHCCCEEEHHHHH
ISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNVKIALTKGRLEKKAIEIFKTININTRELEDKGRKLIFNCENEEYNIELFLVKAKDVE
CCCEEEEEECCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCCEEEEEEEEECCCHH
TYVEYGAADIGIVGKDTLMETNKEFYEVLDLNVGKCKFALAALPSFKLDQGYNRKKIATK
HHHHHCCCCEEECCCHHHHHCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHC
YPNIAREYFRKKGMDVELIKIEGSVELGPIVGLADAIVDIVETGNTLRENGLVVVEDICE
CCHHHHHHHHHCCCCEEEEEEECCEEECHHHHHHHHHHHHHHCCCCHHHCCCEEEHHHHH
ISARMIVNKASMKTKKDEIIKIIENVSEVIRQ
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA