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The map label for this gene is hisB [H]

Identifier: 226948899

GI number: 226948899

Start: 1841006

End: 1841596

Strand: Direct

Name: hisB [H]

Synonym: CLM_1809

Alternate gene names: 226948899

Gene position: 1841006-1841596 (Clockwise)

Preceding gene: 226948898

Following gene: 226948900

Centisome position: 44.31

GC content: 32.66

Gene sequence:

>591_bases
ATGAAAGAAAGCATAGCTAAAGTTTATAGAAAAACTGGAGAAACAGAAATAAAGTCGGAAATTAATTTATATGGAGAAGG
AAAATATGATATAAAAACCGGTATAGGTTTTTTTGATCATATGTTAAATCTTATGGCAAGGCATGGACTTATTGATGTAA
AACTAGAGGCAAAAGGTGACTTACAGGTAGATTCTCATCATACCGTGGAGGATGTAGGCATAGTTTTAGGTGAAAGTTTT
AAAAAAGCTCTAGGGGATAAAAAAGGTATTAAAAGATACGGAACTAGTTTTGTTCCTATGGATGAAGCCTTAGCCAGTGT
GTCTATAGATATAAGTGGAAGACCATATATAGTATGTGATTTTAACTTTACTGTAGACAAATTAGGTGGAATGGATACAG
AATTAGTGGAAGAATTTTTAAGAGCATTGGCTTTTAACGTTGGAATAACTTTACATGCTAGAGTATTATATGGTAAGAAT
AATCATCATATGATAGAAGCGGTTTTTAAAGCTTTAGGCAGAGCTCTTAGGGAAGCTGTAGATAGAGATGAAAAAATAAA
TGGGGTTATGTCTACTAAAGGTACACTATAG

Upstream 100 bases:

>100_bases
TAGATAAATAGTAGTTTAATATGTTTCCTATAAAAATACAATTGGAACAGTTTATAATTATTAAATAAAATTCATATACC
ATGGAAAAGAGGATAAAGTT

Downstream 100 bases:

>100_bases
AAATAATAAATATGAATTATATTAGAAACAATTATGTTTATTATTAAATATTACAAGCTTTACAATGAGTAATAGGGGAT
ATATAAAGCCAATAACATTA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGGMDTELVEEFLRALAFNVGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL

Sequences:

>Translated_196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGGMDTELVEEFLRALAFNVGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL
>Mature_196_residues
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGDLQVDSHHTVEDVGIVLGESF
KKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCDFNFTVDKLGGMDTELVEEFLRALAFNVGITLHARVLYGKN
NHHMIEAVFKALGRALREAVDRDEKINGVMSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=197, Percent_Identity=46.7005076142132, Blast_Score=183, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=40.4545454545455, Blast_Score=164, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21752; Mature: 21752

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGD
CCHHHHHHHHHCCCHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LQVDSHHTVEDVGIVLGESFKKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCD
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHEEEEEECCCCEEEEE
FNFTVDKLGGMDTELVEEFLRALAFNVGITLHARVLYGKNNHHMIEAVFKALGRALREAV
CCCCHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
DRDEKINGVMSTKGTL
CCHHHCCCHHCCCCCC
>Mature Secondary Structure
MKESIAKVYRKTGETEIKSEINLYGEGKYDIKTGIGFFDHMLNLMARHGLIDVKLEAKGD
CCHHHHHHHHHCCCHHHHHHEEEECCCCEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
LQVDSHHTVEDVGIVLGESFKKALGDKKGIKRYGTSFVPMDEALASVSIDISGRPYIVCD
EEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHEEEEEECCCCEEEEE
FNFTVDKLGGMDTELVEEFLRALAFNVGITLHARVLYGKNNHHMIEAVFKALGRALREAV
CCCCHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
DRDEKINGVMSTKGTL
CCHHHCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA