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The map label for this gene is hemC [H]

Identifier: 226948193

GI number: 226948193

Start: 1117795

End: 1118667

Strand: Direct

Name: hemC [H]

Synonym: CLM_1068

Alternate gene names: 226948193

Gene position: 1117795-1118667 (Clockwise)

Preceding gene: 226948192

Following gene: 226948194

Centisome position: 26.9

GC content: 31.16

Gene sequence:

>873_bases
TTGAATTTTGTAATAGCCACACGAAGAAGTAAGCTTGCTCAGGTGCAAACAGAAATAATAATAGATTTATTAAATAAAAA
GCATGATATAGAATGTGAAAAATTATTAATAGAAACCGTAGGAGATAAAATATTAGAAGTATCTTTAGATAAGATAGGTG
GAAAAGGGCTATTTGTTAAAGACATAGAAGTAGCTATGTTAGAACAAAGGGCAGATGCAGCAGTACATAGTATGAAGGAT
GTGCCCTATGAAATGCCAAAAGGTTTTGAGATAATAGCTATTCCAGAGCGAGAAGATGTAAGAGATGCCTTTATATCCTT
AGACAATATAAAATTTAAGGATTTAAGAAAGGGAGCTAAAATTGGTACAAGTAGTAGGAGAAGGGCAGCCCAATTAAAAC
TTCTAAGGCCAGATTTAGATATTGTACCCATAAGAGGAAATGTTCAAACTAGAATAGAAAAAATAAAAAAAGAAAATCTA
GATGGAATAATATTAGCAGTAGCAGGCCTTAAAAGGGTAAATTTAGATCATTTAATTACAGACTATTTTGATACAAAAGA
AATGGTACCCGCAATTGGTCAAGGTGCCTTAGGTATAGAAGTTATGGAGGAGCATCCTAAAAAGGAGTTATTTAAGGATT
TAGATCATTATAATTCAAAAATATGTGTTTTGGCAGAAAGAGCTTTTATGAGGGAACTAGATGGAGATTGCCACTCAACT
ATAGGAGCTTATGCATCTATAAAGGATAATATAATGCATATAATAGGCATATTTGAAAGAAAAAATAAAATTATTAAAAA
AGAAATCACAGGAACAAAAGATCAGTATGAAAAATTAGGCATATCTCTAGCAGAACATATACTAAAAGACTAA

Upstream 100 bases:

>100_bases
GATGAAATTATAGATTTTATCTGCAGCAATGATTTTCACTTCTTTTTTGAAAAGGGGTATGGTAATCTAATCTTATCAAT
GTTTTATGGAGGTATGGATT

Downstream 100 bases:

>100_bases
AAATTTATTGTTAAAGGTTAAGAATCTTAATAATACTGATCTTAATAGAAGATGTGAGTATTATAAGTGGTATTAGTGGG
AAATAGTAATTTTGAATAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKD
VPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENL
DGIILAVAGLKRVNLDHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHST
IGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD

Sequences:

>Translated_290_residues
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKD
VPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENL
DGIILAVAGLKRVNLDHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHST
IGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD
>Mature_290_residues
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVKDIEVAMLEQRADAAVHSMKD
VPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAKIGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENL
DGIILAVAGLKRVNLDHLITDYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHST
IGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=258, Percent_Identity=36.4341085271318, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI20149500, Length=258, Percent_Identity=36.4341085271318, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI48994974, Length=291, Percent_Identity=45.0171821305842, Blast_Score=226, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319996, Length=251, Percent_Identity=40.2390438247012, Blast_Score=163, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20130425, Length=251, Percent_Identity=37.8486055776892, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32839; Mature: 32839

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVK
CCEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
DIEVAMLEQRADAAVHSMKDVPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCC
IGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENLDGIILAVAGLKRVNLDHLIT
CCCCHHHHHHHHHEECCCCCEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHH
DYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHST
HHHCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHH
IGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFVIATRRSKLAQVQTEIIIDLLNKKHDIECEKLLIETVGDKILEVSLDKIGGKGLFVK
CCEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
DIEVAMLEQRADAAVHSMKDVPYEMPKGFEIIAIPEREDVRDAFISLDNIKFKDLRKGAK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHCCCC
IGTSSRRRAAQLKLLRPDLDIVPIRGNVQTRIEKIKKENLDGIILAVAGLKRVNLDHLIT
CCCCHHHHHHHHHEECCCCCEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHCCHHHHHH
DYFDTKEMVPAIGQGALGIEVMEEHPKKELFKDLDHYNSKICVLAERAFMRELDGDCHST
HHHCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCHHHH
IGAYASIKDNIMHIIGIFERKNKIIKKEITGTKDQYEKLGISLAEHILKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA