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The map label for this gene is gcvPB [H]

Identifier: 226947959

GI number: 226947959

Start: 880463

End: 881917

Strand: Direct

Name: gcvPB [H]

Synonym: CLM_0818

Alternate gene names: 226947959

Gene position: 880463-881917 (Clockwise)

Preceding gene: 226947958

Following gene: 226947960

Centisome position: 21.19

GC content: 31.82

Gene sequence:

>1455_bases
ATGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAAACTTCCTAATTTAGATGTACC
AGAAGTAGAACTTTCAAAATTACTACCTAAAAACTTATTAAGAGAAGATGAAATAGAGCTTCCTGAGGTAAGTGAAGTTG
ATGTTGTAAGACACTATACAGCTCTTTCAAATAAAAATTATACTGTTGATAACGGATTTTATCCATTAGGATCATGCACT
ATGAAATATAATCCTAAAATAAATGAAGATATGGTTGCATTGAGCGGATTTTCAAAAATACATCCACTTCAAGATGAAAA
TATTTCACAGGGTGCATTAGAATTAATGTATGATTTAAAAGGTAAATTATGTGAAATTACAGGATTGGATGATTTTACTC
TTCAACCAGCAGCAGGTGCACATGGTGAGTATACTGGTCTTTTAGTTATAAAAGCTTATCATGAAAAAAGAGGAGATACA
AAAAGAACAAAAATTATAGTTCCCGATTCAGCACATGGTACAAATCCTGCTAGTGCATCAGTAGCCGGATTTGATATTGT
AGAAATAAAATCTGGTGAAGATGGTAGAGTTTCTATTGAAGAACTTAAAAAAGTTTTAAATGACGAAATAGCAGGGTTAA
TGCTTACAAATCCAAGTACCTTAGGCTTATTTGAAAAAGATATAAAACTTATAAGTGAGTTAGTTCATGAAGCCGGTGGA
TTATTATATTATGATGGAGCTAACCTAAATGCAATAATGGGAATTGCAAGGCCAGGGGATATGGGATTCGATGTTTGCCA
CTTAAATATGCATAAAACATTCTCAACTCCACATGGTGGTGGCGGACCGGGATCAGGACCTGTAGGAGTTAAAAAGCATT
TAGCTAAATTCCTTCCAATACCAACAGTTGAAAAGGAAAATGATAAATTTATATTAGATTATAATAGACCAGATTCACTT
GGAAAAATTAGAAGTTTATATGGAAACTTTGGTGTTATGGTTAAAGCATATACTTATATTTTAACAATGGGTAAGGAAGG
ATTAAAATCAGCTTCTGAAAATGCTGTTTTAAATGCAAATTATATAAAAGAATCTTTAAGAGAGTATTATAATATTGGAA
AAGATGATATTTGTAAACATGAGGTGATTTTAAGTACCCTTAAAGAGAATCCACATCATATAGCTACATTGGATATTGCA
AAGAGATTAATAGATTATGGTGTACATCCACCTACAGTTTATTTCCCATTAATAATTGAAGAGGCCCTTATGATAGAGCC
TACTGAAAGTGAAAGTAAAGAGACTGTTGATGAATTTATAGATGCTATGAAAAAAATAGCTGTAGAAGCTAAAGAAAATC
CAGAGCTTTTACATGAGGCACCAGTAAATGCACCAGTAAGAAGATTAGACCAAGTAAAAGCAGCTAGAAAACCTATATTA
AGATGGCAAAAATAA

Upstream 100 bases:

>100_bases
AAGTTTACTCAGAGTATGAAAATTCTATGTTACTTTGTGTTACAGAGAAAAGGACAAGGGAAGATATAGATAATTTAGTA
AAAGTGATGGAGGCGATATA

Downstream 100 bases:

>100_bases
GTGAGGATATGTCTATGCAATCCAATATCATATAGTTTAGTGTATAAAATATAGATATAAATCCTAAAAATCTTACAACT
TTAGTCGTGAGAGGTTCAGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MKDYNKVIFELSSEGRKGYKLPNLDVPEVELSKLLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDMVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLVIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPIPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASENAVLNANYIKESLREYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVNAPVRRLDQVKAARKPIL
RWQK

Sequences:

>Translated_484_residues
MKDYNKVIFELSSEGRKGYKLPNLDVPEVELSKLLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDMVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLVIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPIPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASENAVLNANYIKESLREYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVNAPVRRLDQVKAARKPIL
RWQK
>Mature_484_residues
MKDYNKVIFELSSEGRKGYKLPNLDVPEVELSKLLPKNLLREDEIELPEVSEVDVVRHYTALSNKNYTVDNGFYPLGSCT
MKYNPKINEDMVALSGFSKIHPLQDENISQGALELMYDLKGKLCEITGLDDFTLQPAAGAHGEYTGLLVIKAYHEKRGDT
KRTKIIVPDSAHGTNPASASVAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPIPTVEKENDKFILDYNRPDSL
GKIRSLYGNFGVMVKAYTYILTMGKEGLKSASENAVLNANYIKESLREYYNIGKDDICKHEVILSTLKENPHHIATLDIA
KRLIDYGVHPPTVYFPLIIEEALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVNAPVRRLDQVKAARKPIL
RWQK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=410, Percent_Identity=42.6829268292683, Blast_Score=296, Evalue=4e-80,
Organism=Escherichia coli, GI1789269, Length=475, Percent_Identity=39.7894736842105, Blast_Score=295, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=409, Percent_Identity=42.5427872860636, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI32564013, Length=368, Percent_Identity=42.9347826086957, Blast_Score=265, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6323843, Length=435, Percent_Identity=42.7586206896552, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24645648, Length=467, Percent_Identity=39.4004282655246, Blast_Score=291, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53719; Mature: 53719

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDYNKVIFELSSEGRKGYKLPNLDVPEVELSKLLPKNLLREDEIELPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDMVALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCCCCEECCCCHHCCCCCCCCCCHHHHHHHHHHC
GKLCEITGLDDFTLQPAAGAHGEYTGLLVIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
CCEEEEECCCCCEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPI
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNRPDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKSASENAVLNAN
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHCCCCCCEEEHH
YIKESLREYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVNAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
RWQK
CCCC
>Mature Secondary Structure
MKDYNKVIFELSSEGRKGYKLPNLDVPEVELSKLLPKNLLREDEIELPEVSEVDVVRHYT
CCCHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
ALSNKNYTVDNGFYPLGSCTMKYNPKINEDMVALSGFSKIHPLQDENISQGALELMYDLK
HHCCCCEEECCCCEECCCEEEEECCCCCCCCEECCCCHHCCCCCCCCCCHHHHHHHHHHC
GKLCEITGLDDFTLQPAAGAHGEYTGLLVIKAYHEKRGDTKRTKIIVPDSAHGTNPASAS
CCEEEEECCCCCEECCCCCCCCCEEEEEEEEEEHHCCCCCCCEEEEECCCCCCCCCCCCC
VAGFDIVEIKSGEDGRVSIEELKKVLNDEIAGLMLTNPSTLGLFEKDIKLISELVHEAGG
CCCEEEEEEECCCCCCEEHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCC
LLYYDGANLNAIMGIARPGDMGFDVCHLNMHKTFSTPHGGGGPGSGPVGVKKHLAKFLPI
EEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
PTVEKENDKFILDYNRPDSLGKIRSLYGNFGVMVKAYTYILTMGKEGLKSASENAVLNAN
CCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHCCCCCCEEEHH
YIKESLREYYNIGKDDICKHEVILSTLKENPHHIATLDIAKRLIDYGVHPPTVYFPLIIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCEEHHHHHH
EALMIEPTESESKETVDEFIDAMKKIAVEAKENPELLHEAPVNAPVRRLDQVKAARKPIL
HHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
RWQK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]