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The map label for this gene is gcvPA [H]

Identifier: 226947958

GI number: 226947958

Start: 879123

End: 880463

Strand: Direct

Name: gcvPA [H]

Synonym: CLM_0817

Alternate gene names: 226947958

Gene position: 879123-880463 (Clockwise)

Preceding gene: 226947957

Following gene: 226947959

Centisome position: 21.16

GC content: 32.59

Gene sequence:

>1341_bases
ATGTTTCCATATATTCCAAACACAGAAAAAGAAACAAAAGAAATTTTAGATTTTCTTTCAATAAAATCTGTAGATGAATT
ATTTAGTGATATACCAGATAATCTGAAGTTGAATAGGGAGTTAGACCTAGAGAGTTCTTTATCAGAACTAGAGGTTGAAA
AAAGATTAAAAGCCTTAGCTTTAAAAAATAAATCTATGGAAGATATGACATGTTTCTTAGGGGCTGGAATTTATGATCAT
TATATACCTTCTGTAATTAAACATATAACAGGAAGATCAGAATTCTATACAGCATATACACCTTACCAACCAGAGGTAAG
TCAAGGAACACTCCAAGCTATATTTGAATATCAAAGCATGATTTGCGCTTTAACAGGCATGGAAGTTTCAAACTCTTCTA
TGTATGATGGGGCGACAGCAACAGCTGAGGCAGCTATACTTGCTATTGCTAGTACTAAAAGAAATACTATTATAGTTTCT
AGATCAGTAAATCCTGACACAAGAAAAGTGCTTAAAACTTACTTAAAGTATAGAGGTTACAATATGGTAGAGGTTGATTT
AGAAGAGGGGACTACAGATGTAGATAAAGTCATTAATAGCTTAGATAAAAATGTAGCTGCAGTTATAATTCAAAGCCCAA
ACTTCCTTGGTTTAGTTGAAGATGTTGAAAACATGGTAGAGGCTATTCATAAAAATAAGTCACTATTAATAATGAATGTA
GACCCAATATCATTAGGTATATTAAAAAGTCCGGGAGAATTAGGTGCAGATATTGTTGTTGGCGATGGGCAATGTTTAGG
TGCCAACATGAGCTATGGCGGCCCAGGTTTTGGATTTATGAATACTACAAAAAAACTTATGAGAAAAATGCCAGGTAGGA
TAGTTGGTGAAACTGAAGATGTTGAAGGAAAAAGAGGATTTGTTTTAACACTTCAAGCTAGAGAACAACATATAAGGAGA
GAAAAAGCAACTTCTAATATTTGTTCAGACCAAACAGCAGTAGCAATAGGTGCAGCTGTTTATATGGCTACTTTAGGAAA
AGAGGGAATAAAGGAAGTAGCAAAACAATGTGTAGTTAAATCACACTATGCATATAATGAGTTAATTAAATCAGGAAAAT
ATAAGCCTGTGTTCAATAAACCATTCTTCAAGGAGTTTGTAGTAAAAGCAGAAACTTTACCTTGCGAAATTAATGATAAA
TTATTAGAAAATAATATTTTAGGTGGATATGATTTAGGGAAAGTTTACTCAGAGTATGAAAATTCTATGTTACTTTGTGT
TACAGAGAAAAGGACAAGGGAAGATATAGATAATTTAGTAAAAGTGATGGAGGCGATATAA

Upstream 100 bases:

>100_bases
TTATTGCAGTAGAGATGTCAGATAAAAGTGAATTAGAAGAATTAATAAAACCAGAAGTTTATGAGAAAATATGTGAAGAG
TTAGATAAGGAGGCATAATT

Downstream 100 bases:

>100_bases
TGAAAGATTATAATAAAGTTATATTTGAGCTGTCATCAGAAGGTAGAAAAGGCTATAAACTTCCTAATTTAGATGTACCA
GAAGTAGAACTTTCAAAATT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILAIASTKRNTIIVS
RSVNPDTRKVLKTYLKYRGYNMVEVDLEEGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVEAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVVKSHYAYNELIKSGKYKPVFNKPFFKEFVVKAETLPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI

Sequences:

>Translated_446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILAIASTKRNTIIVS
RSVNPDTRKVLKTYLKYRGYNMVEVDLEEGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVEAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVVKSHYAYNELIKSGKYKPVFNKPFFKEFVVKAETLPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI
>Mature_446_residues
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELDLESSLSELEVEKRLKALALKNKSMEDMTCFLGAGIYDH
YIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSMICALTGMEVSNSSMYDGATATAEAAILAIASTKRNTIIVS
RSVNPDTRKVLKTYLKYRGYNMVEVDLEEGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVEAIHKNKSLLIMNV
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETEDVEGKRGFVLTLQAREQHIRR
EKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVVKSHYAYNELIKSGKYKPVFNKPFFKEFVVKAETLPCEINDK
LLENNILGGYDLGKVYSEYENSMLLCVTEKRTREDIDNLVKVMEAI

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=355, Percent_Identity=38.0281690140845, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1789269, Length=440, Percent_Identity=31.1363636363636, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17535605, Length=397, Percent_Identity=38.5390428211587, Blast_Score=253, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323843, Length=424, Percent_Identity=33.2547169811321, Blast_Score=230, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24645648, Length=395, Percent_Identity=35.1898734177215, Blast_Score=248, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49588; Mature: 49588

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELDLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILAIASTKRNTIIVSRSVNPDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCCHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCC
NMVEVDLEEGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVEAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEEC
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETED
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVVK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPVFNKPFFKEFVVKAETLPCEINDKLLENNILGGYDLGKVYSEYE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKVMEAI
CCEEEEEECHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFPYIPNTEKETKEILDFLSIKSVDELFSDIPDNLKLNRELDLESSLSELEVEKRLKALA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LKNKSMEDMTCFLGAGIYDHYIPSVIKHITGRSEFYTAYTPYQPEVSQGTLQAIFEYQSM
HCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHH
ICALTGMEVSNSSMYDGATATAEAAILAIASTKRNTIIVSRSVNPDTRKVLKTYLKYRGY
HHHHHCCEECCCCCCCCCCHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCC
NMVEVDLEEGTTDVDKVINSLDKNVAAVIIQSPNFLGLVEDVENMVEAIHKNKSLLIMNV
CEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEEC
DPISLGILKSPGELGADIVVGDGQCLGANMSYGGPGFGFMNTTKKLMRKMPGRIVGETED
CCCEEEEECCCCCCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCC
VEGKRGFVLTLQAREQHIRREKATSNICSDQTAVAIGAAVYMATLGKEGIKEVAKQCVVK
CCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
SHYAYNELIKSGKYKPVFNKPFFKEFVVKAETLPCEINDKLLENNILGGYDLGKVYSEYE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHC
NSMLLCVTEKRTREDIDNLVKVMEAI
CCEEEEEECHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]