Click here to switch to the map view.

The map label for this gene is gudP [H]

Identifier: 226225366

GI number: 226225366

Start: 2867492

End: 2868685

Strand: Reverse

Name: gudP [H]

Synonym: Lm4b_02789

Alternate gene names: 226225366

Gene position: 2868685-2867492 (Counterclockwise)

Preceding gene: 226225367

Following gene: 226225364

Centisome position: 98.49

GC content: 38.94

Gene sequence:

>1194_bases
ATGAATCAGGTAAAAGGAGAAAAGCATTCGTTAATGGTGTTACTTGTTCTATTTATAGGCTACACTAGTGTATACGTGGA
TAAATATACTATTGGAATTTCGCTTGTGACTGTTTCTCAGGATTTAGGATTTGATCCAAGTCAAAAGGGGTTGATTTTAA
GTGCCTTCTTTCTTGGTTACACACTTTTTCAAATTCCAATGGGGTATTTAAACAATCGGATTGGCGCACGACCAGTTCTT
GCGGTATCAATTATTATTGTCGGGCTATTTCTTGTTATTTTTGGCTTTGGCTATTCCTTGTTGTTTTTGGTTGTTATTCG
TTTCTTATCCGGAGCACTTGGACACGCGGGTTATCCCCCGTCTGTCAGCAATTATATTTCACTTCATATTCCGTTGAACA
AGCGAGGTTTTGCTCAGTCCGCAATGCTCGCTTCCTCTGGTTTTGCGGCATTTATTGGGCCATTGTTAATCGCGCAACTG
TTGCTATCAGTGGGTTGGCGCAATACATATTACTGGATTGGTATTGCGGTGATTTTGATTGGCTTTCTGATTTTAATTGT
CGTACCTAAAGCGCCGAAAATAGACCTAAATGCTCAAAAAGAAAAAATCAAAGTACCTTTCTCAGAACTTTTGAAAGATA
AACAGCTTTGGATTCTTTTGCTATCAGCGCTTTTTATAAATGCAGCGAACTACGGTTTAACAAGTTGGCTTGCTTCTTAT
TTGAATGAGGTTAGAGGGATTTCTATTAGCGAAGTGAGCTATATTAGCTCTTTAGCTGGCCTTTGTATTTTAATTGCAGG
AGTTGTCGGTGGCTATTTCATTAGTCGTTTTTTCAAAGGAAAAGAGCCGATTATTATTTTCGCATTTTGTGTGCTTGGAG
CGTTCGCGGTATACGGGGTGTATTTATTTGAACAATTAGCGCTATCGGTTATTTGCTTGTGTTTATGTAATATATTCCTA
ATCATGGCCTTTACAACGCTAATGGGATTGCCGCACAAGTTGTTTCAGCAGAGCCACATTGCAACAAAATACGCGGCTAT
AAACTCGGGCGGAGTTTTAGGTGGCTTTTTTGCACCGATGATTATAGGGGATTTGGTAAACGCGACTAACTCTTATCAAT
CGGCTTTTCTGTTCTTGGCGTTAACTTTATTAGCATCGGGATTGATTGTTTTAGCGATTAAAAAAGACCAATAA

Upstream 100 bases:

>100_bases
ATTAAATGGATAATAGCTTTGAAAAGAGCATAGTCAGAAAAAGAATCTGGTTATGCTCTTTTGCAATTGGCGGGACTATA
GAAGAGTGGAGTGAATTCAA

Downstream 100 bases:

>100_bases
AATAAAAGGAGGAAAACCAGATAGCTCTGTTTTCCTCCTTTTTTAATTAAGCTAATCCGCCATTGGTGAAAATGACTTGA
CCATTCACCCAGCGTGCAGG

Product: transport protein

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNQVKGEKHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLGYTLFQIPMGYLNNRIGARPVL
AVSIIIVGLFLVIFGFGYSLLFLVVIRFLSGALGHAGYPPSVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQL
LLSVGWRNTYYWIGIAVILIGFLILIVVPKAPKIDLNAQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLASY
LNEVRGISISEVSYISSLAGLCILIAGVVGGYFISRFFKGKEPIIIFAFCVLGAFAVYGVYLFEQLALSVICLCLCNIFL
IMAFTTLMGLPHKLFQQSHIATKYAAINSGGVLGGFFAPMIIGDLVNATNSYQSAFLFLALTLLASGLIVLAIKKDQ

Sequences:

>Translated_397_residues
MNQVKGEKHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLGYTLFQIPMGYLNNRIGARPVL
AVSIIIVGLFLVIFGFGYSLLFLVVIRFLSGALGHAGYPPSVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQL
LLSVGWRNTYYWIGIAVILIGFLILIVVPKAPKIDLNAQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLASY
LNEVRGISISEVSYISSLAGLCILIAGVVGGYFISRFFKGKEPIIIFAFCVLGAFAVYGVYLFEQLALSVICLCLCNIFL
IMAFTTLMGLPHKLFQQSHIATKYAAINSGGVLGGFFAPMIIGDLVNATNSYQSAFLFLALTLLASGLIVLAIKKDQ
>Mature_397_residues
MNQVKGEKHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLGYTLFQIPMGYLNNRIGARPVL
AVSIIIVGLFLVIFGFGYSLLFLVVIRFLSGALGHAGYPPSVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQL
LLSVGWRNTYYWIGIAVILIGFLILIVVPKAPKIDLNAQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLASY
LNEVRGISISEVSYISSLAGLCILIAGVVGGYFISRFFKGKEPIIIFAFCVLGAFAVYGVYLFEQLALSVICLCLCNIFL
IMAFTTLMGLPHKLFQQSHIATKYAAINSGGVLGGFFAPMIIGDLVNATNSYQSAFLFLALTLLASGLIVLAIKKDQ

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI154350196, Length=233, Percent_Identity=25.3218884120172, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI21322234, Length=417, Percent_Identity=24.4604316546763, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI9966811, Length=393, Percent_Identity=22.9007633587786, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI6912666, Length=375, Percent_Identity=25.6, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI256219598, Length=280, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4503847, Length=280, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI256219483, Length=280, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI256219543, Length=280, Percent_Identity=22.5, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789152, Length=298, Percent_Identity=29.1946308724832, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI2367379, Length=402, Percent_Identity=21.8905472636816, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789515, Length=313, Percent_Identity=25.8785942492013, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082320, Length=410, Percent_Identity=22.1951219512195, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082071, Length=413, Percent_Identity=21.3075060532688, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17535049, Length=424, Percent_Identity=22.1698113207547, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560030, Length=258, Percent_Identity=23.6434108527132, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533554, Length=411, Percent_Identity=21.654501216545, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115533556, Length=411, Percent_Identity=21.654501216545, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639764, Length=307, Percent_Identity=25.7328990228013, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584153, Length=363, Percent_Identity=23.1404958677686, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648416, Length=303, Percent_Identity=22.7722772277228, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356189, Length=303, Percent_Identity=22.7722772277228, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24654215, Length=318, Percent_Identity=25.1572327044025, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922400, Length=304, Percent_Identity=25, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43209; Mature: 43209

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVKGEKHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
TLFQIPMGYLNNRIGARPVLAVSIIIVGLFLVIFGFGYSLLFLVVIRFLSGALGHAGYPP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQLLLSVGWRNTYYWIGIAVILI
CCCCEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GFLILIVVPKAPKIDLNAQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLASY
HHHHHHHCCCCCCCCCCCCHHHEECCHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LNEVRGISISEVSYISSLAGLCILIAGVVGGYFISRFFKGKEPIIIFAFCVLGAFAVYGV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YLFEQLALSVICLCLCNIFLIMAFTTLMGLPHKLFQQSHIATKYAAINSGGVLGGFFAPM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHH
IIGDLVNATNSYQSAFLFLALTLLASGLIVLAIKKDQ
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
>Mature Secondary Structure
MNQVKGEKHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLGY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
TLFQIPMGYLNNRIGARPVLAVSIIIVGLFLVIFGFGYSLLFLVVIRFLSGALGHAGYPP
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQLLLSVGWRNTYYWIGIAVILI
CCCCEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GFLILIVVPKAPKIDLNAQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLASY
HHHHHHHCCCCCCCCCCCCHHHEECCHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LNEVRGISISEVSYISSLAGLCILIAGVVGGYFISRFFKGKEPIIIFAFCVLGAFAVYGV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YLFEQLALSVICLCLCNIFLIMAFTTLMGLPHKLFQQSHIATKYAAINSGGVLGGFFAPM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHH
IIGDLVNATNSYQSAFLFLALTLLASGLIVLAIKKDQ
HHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9772162; 10762278 [H]