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The map label for this gene is guaB

Identifier: 226225310

GI number: 226225310

Start: 2810473

End: 2811939

Strand: Reverse

Name: guaB

Synonym: Lm4b_02733

Alternate gene names: 226225310

Gene position: 2811939-2810473 (Counterclockwise)

Preceding gene: 226225311

Following gene: 226225309

Centisome position: 96.54

GC content: 41.65

Gene sequence:

>1467_bases
ATGTGGGAAACAAAATTTGCAAAAGAAGGCTTAACATTTGATGATGTTTTACTTGTTCCAGCGAAATCGGACGTATTACC
AAATGATGTAGATTTAAGTGTAGAAATGGCTCCATCACTCAAATTAAATGTACCAATTTGGAGTGCCGGAATGGACACAA
TTACAGAAGCTAAAATGGCAATTGCAATTGCGCGCCAAGGCGGAATCGGTGTTGTTCATAAGAATATGAGTATTGAACAA
CAAGCGGAAGAAATCGAGAAGGTGAAACGCTCTGAAAGTGGCGTTATTATTGATCCATTTTATCTGACTCCAGATCACCA
AGTTTTTGCTGCAGAGCATTTGATGGGTAAATATCGTATCTCAGGTGTTCCAATCGTGAACAACGAGAAAGAGCGCAAAC
TAGTTGGGATTTTAACTAACCGCGATTTACGTTTTATTTCCGATTATTCTACAGTAATTAAAGATGTTATGACAAAGGAA
AACCTAGTGACAGCGCCAGTTGGAACTACGCTAAAACAAGCTGAGCAGATTCTGCAAAAACACCGCATCGAGAAATTGCC
ACTTGTTGACGAAGCAGGTATTCTAAAAGGGCTTATCACTATTAAAGATATTGAAAAAGTAATTGAATTCCCGAACTCTG
CTAAAGACAAGCATGGTAGACTACTTGCCGCAGCAGCTGTTGGAATTACGAATGATACTTTTGTACGTGTAGAGAAATTA
ATCGAGGCGGGTGTTGATGCGATTGTTATTGATACTGCGCACGGACATTCAGCGGGAGTTATTAATAAAATTTCCGAAAT
TCGCCAAACTTTCAAAGATGTAGTAATTGTTGCCGGAAACGTTGCAACAGCTGAAGGAGCACGTGCTCTTTTTGAAGTTG
GCGTTGATATCGTCAAAGTTGGGATTGGTCCTGGTTCCATCTGTACGACACGTGTTGTTGCAGGCGTTGGGGTTCCTCAA
ATTACAGCGATTTACGATTGTGCAACTGTTGCGCGTGAATTTGGTAAAACAATTATCGCAGACGGCGGCATTAAATACTC
CGGTGATATCGTGAAAGCTCTAGCTGCTGGAGGAAATGCGGTTATGCTAGGAAGTATGCTTGCTGGAACAGACGAAAGCC
CTGGTGAAACAGAAATTTTCCAAGGTCGTCAATTCAAAACTTACCGTGGTATGGGTAGTTTGGCAGCGATGGAGCACGGT
TCAAAAGATCGTTATTTCCAAGCAGATGCGAAAAAATTGGTTCCTGAAGGTATTGAAGGTCGCGTTCCTTACAAAGGCTC
CGTTGCTGATATTATCTTCCAATTAGTTGGCGGTATTCGTTCAGGTATGGGTTACACTGGCTCTCCTGATTTAAGACATC
TTCGTGAAGAAGCAGCATTCGTTCGTATGACTGGCGCTGGACTCCGTGAAAGCCACCCACATGATATTCAAATTACAAAA
GAAGCACCAAACTATAGCATTTCTTAA

Upstream 100 bases:

>100_bases
ATATTTTCCACCATTTTTTCTTTATGAAAATAAGGATAAGATGATGCGTTTTTTCTATATAAAAAAGCGAGTACCAATAA
AAAAGGAGTGTTTGCGACCC

Downstream 100 bases:

>100_bases
GGTCGAAAAAGCAGGAATCTCTTCCAAAAGAGGTTTCTGCTTTTTTATTTCTACTATAAAAATAAGAAAGCTGCGAGAAA
ACACGAATTTCTCCAAAAAG

Product: inosine-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH; Superoxide-inducible protein 12; SOI12 [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQ
QAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKE
NLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKL
IEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHG
SKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITK
EAPNYSIS

Sequences:

>Translated_488_residues
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQ
QAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKE
NLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKL
IEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHG
SKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITK
EAPNYSIS
>Mature_488_residues
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQ
QAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKE
NLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKL
IEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQ
ITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHG
SKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITK
EAPNYSIS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=455, Percent_Identity=42.4175824175824, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI156616279, Length=455, Percent_Identity=42.4175824175824, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI34328930, Length=455, Percent_Identity=42.4175824175824, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI34328928, Length=455, Percent_Identity=42.4175824175824, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI66933016, Length=480, Percent_Identity=39.5833333333333, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=42.5055928411633, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035148, Length=455, Percent_Identity=41.7582417582418, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI217035150, Length=455, Percent_Identity=39.5604395604396, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI50541956, Length=243, Percent_Identity=40.7407407407407, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541954, Length=243, Percent_Identity=40.7407407407407, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541952, Length=243, Percent_Identity=40.7407407407407, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI50541948, Length=243, Percent_Identity=40.7407407407407, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI156104880, Length=243, Percent_Identity=38.2716049382716, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=54.7325102880658, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1786293, Length=240, Percent_Identity=36.25, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=36.6108786610879, Blast_Score=282, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI71994389, Length=428, Percent_Identity=37.6168224299065, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=245, Percent_Identity=37.9591836734694, Blast_Score=171, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=38.4615384615385, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6322012, Length=456, Percent_Identity=37.5, Blast_Score=313, Evalue=5e-86,
Organism=Saccharomyces cerevisiae, GI6323464, Length=456, Percent_Identity=39.4736842105263, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=36.9822485207101, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=113, Percent_Identity=42.4778761061947, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=39.7089397089397, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=39.7089397089397, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=39.6355353075171, Blast_Score=301, Evalue=5e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52556; Mature: 52556

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMA
CCCCCHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCEECCCCHHHHHHHHE
IAIARQGGIGVVHKNMSIEQQAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRI
EEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHEEE
SGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKENLVTAPVGTTLKQAEQILQK
CCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
HRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKL
HCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
IEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCEEEEE
GIGPGSICTTRVVAGVGVPQITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNA
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCCCE
VMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHGSKDRYFQADAKKLVPEGIEG
EEEEHHHCCCCCCCCCCHHHCCCCEEHHCCCCHHHHHHCCCCCCEEECCHHHHCCCCCCC
RVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEE
EAPNYSIS
CCCCCCCC
>Mature Secondary Structure
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMA
CCCCCHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCEECCCCHHHHHHHHE
IAIARQGGIGVVHKNMSIEQQAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRI
EEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHEEE
SGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKENLVTAPVGTTLKQAEQILQK
CCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
HRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKL
HCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHH
IEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKV
HHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHCCEEEEE
GIGPGSICTTRVVAGVGVPQITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNA
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCCCE
VMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHGSKDRYFQADAKKLVPEGIEG
EEEEHHHCCCCCCCCCCHHHCCCCEEHHCCCCHHHHHHCCCCCCEEECCHHHHCCCCCCC
RVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITK
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEE
EAPNYSIS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1979163; 7584024; 9384377; 9298659 [H]