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The map label for this gene is ydfD [H]

Identifier: 226224705

GI number: 226224705

Start: 2179394

End: 2180839

Strand: Reverse

Name: ydfD [H]

Synonym: Lm4b_02121

Alternate gene names: 226224705

Gene position: 2180839-2179394 (Counterclockwise)

Preceding gene: 226224708

Following gene: 226224704

Centisome position: 74.87

GC content: 42.05

Gene sequence:

>1446_bases
ATGTGGAAACTTGCTGGAAATTCTAATTTACCAATTTATTTACAAATTGTAGATTTAATAGAAACAAAAATTATCAACGG
AGAACTTTTGCCAGAAGAGAAGTTGCCTCCGGAAAGACAGTTGGCGGAAATGTTTGGGGTAAATCGTTCGACGGTTGTGC
GGGCGCTCGATGAACTTACAGCACGTGCGGTTATCATTCGCAAACAAGGTAGTGGAACGACAGTCAATGCGGAAAAATGG
GGGCTTTTTGCAGGGCAGTCAACCAATTGGCGCCATTATTTAACGCAAGGGGGCTTTACACCAGCAGTCCCTTATATTCG
GCAAGCGGGAGTAATGGAACGAGCTGATTCGGATCAAGTGATTGATGCAGCGAGCGGGGAATTGCCACTTGAAATGACGC
CAAAAATGGAAACACCGAGTCTTTCATGGCAGTCTTTTATTGCAGAAGAACAACAGGAGGATGAAGCGGGATACAAACCA
CTGCGTGAAACGATTCAAAAACAGATGAAGGAAGCTTATGGCTTACAAACACGACCCGAACAAATTTTCATTACATCGGG
TGCACAACAAGCGCTCTTTTTAATTACGCAATGTTTATTAAAACCGGGTGATGCTGTGGCAATTGAGTCGCCTTCCTACT
TTTATTCGCTATCGTTGTTTCAGTCAGCCGGTTTGCGGATTTTTGCGCTACCAATGGACGAGGATGGCGTGATTATTTCT
GAATTACGCGATTTATACCATAAACACCGTGTGAAAATGGTTTTTGTTAATCCAACCTTTCAAAATCCAACTGGACTTGT
AATGAGTTTGGAACGGCGCAAAGAACTCGTGAAAATTTGCGCTCATTTGCAAATACCGATAGTTGAAGATGATCCATTTT
CAGAACTAGCCGCACTAGACAGCCAAATTCCGGCACCACTGAAACAACTGGACACGGATAATGTGTTATACATTGGCTCG
CTCTCAAAAATTATGGGATCCACTACACGAATCGGTTGGCTTATTGGTCCGACAGCAGTAATTGAACGGCTCGCGCTCGC
CAGGCAAGAGATGGATTTTGGTTTAAGTATTTTTCCACAAGTATTGGCAAATAGTGTTTTGAATACGCCCGGTTACAAGG
TGCATTTACAGCAATTGCACCACGTATTAAAACAGCGCCGAGGTGATTTAATCGAAGCTTTCGAAGCCATTTTACCGAAT
GATGTAGTATTTATTAAGCCAAAAGGTGGTTTTCATTTATGGGTGAAATTACCAGTCGAAATTCGCTCGATTCGTGATTT
TGATATATTTTTAGCGAATGATTTACTTGTTATGCCAGGATTTTTATTTGGGGTAAAAGAAGCGGTTATCCGTGTAACTT
ATGCGCGGCTTGAGAAGACGGAAGCGAGACGTATAGCTGAAATAATAAAGCAAATATTAATAGAAAAAAAGTGCGAGGAA
GCTTGA

Upstream 100 bases:

>100_bases
ATTGAAAATACCTGATTATTATGATAAGCTAAAAGCCATTTCGTAAAAACAGCCAATTGGATGTTGTTTTCTCCATCCAA
TTATAAAAGAGGTGTAGTAG

Downstream 100 bases:

>100_bases
TTTAAAGCTATCTTGCACTTTTTTCATATTCCCCAAAAAATCCTTCTAATCTATAATAGAAAGTAACCCGCGATTTTAAC
TCATCACAATAAATCTTTCT

Product: transcriptional regulator, GntR family/aminotransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MWKLAGNSNLPIYLQIVDLIETKIINGELLPEEKLPPERQLAEMFGVNRSTVVRALDELTARAVIIRKQGSGTTVNAEKW
GLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERADSDQVIDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKP
LRETIQKQMKEAYGLQTRPEQIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVIIS
ELRDLYHKHRVKMVFVNPTFQNPTGLVMSLERRKELVKICAHLQIPIVEDDPFSELAALDSQIPAPLKQLDTDNVLYIGS
LSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQVLANSVLNTPGYKVHLQQLHHVLKQRRGDLIEAFEAILPN
DVVFIKPKGGFHLWVKLPVEIRSIRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKTEARRIAEIIKQILIEKKCEE
A

Sequences:

>Translated_481_residues
MWKLAGNSNLPIYLQIVDLIETKIINGELLPEEKLPPERQLAEMFGVNRSTVVRALDELTARAVIIRKQGSGTTVNAEKW
GLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERADSDQVIDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKP
LRETIQKQMKEAYGLQTRPEQIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVIIS
ELRDLYHKHRVKMVFVNPTFQNPTGLVMSLERRKELVKICAHLQIPIVEDDPFSELAALDSQIPAPLKQLDTDNVLYIGS
LSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQVLANSVLNTPGYKVHLQQLHHVLKQRRGDLIEAFEAILPN
DVVFIKPKGGFHLWVKLPVEIRSIRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKTEARRIAEIIKQILIEKKCEE
A
>Mature_481_residues
MWKLAGNSNLPIYLQIVDLIETKIINGELLPEEKLPPERQLAEMFGVNRSTVVRALDELTARAVIIRKQGSGTTVNAEKW
GLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERADSDQVIDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKP
LRETIQKQMKEAYGLQTRPEQIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVIIS
ELRDLYHKHRVKMVFVNPTFQNPTGLVMSLERRKELVKICAHLQIPIVEDDPFSELAALDSQIPAPLKQLDTDNVLYIGS
LSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQVLANSVLNTPGYKVHLQQLHHVLKQRRGDLIEAFEAILPN
DVVFIKPKGGFHLWVKLPVEIRSIRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKTEARRIAEIIKQILIEKKCEE
A

Specific function: Unknown

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=318, Percent_Identity=25.7861635220126, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33469970, Length=318, Percent_Identity=25.7861635220126, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1790797, Length=489, Percent_Identity=26.5848670756646, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787710, Length=452, Percent_Identity=25.6637168141593, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788722, Length=376, Percent_Identity=23.4042553191489, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321236, Length=283, Percent_Identity=25.7950530035336, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356535, Length=426, Percent_Identity=21.1267605633803, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 54136; Mature: 54136

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKLAGNSNLPIYLQIVDLIETKIINGELLPEEKLPPERQLAEMFGVNRSTVVRALDELT
CEEECCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
ARAVIIRKQGSGTTVNAEKWGLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERADSDQV
HEEEEEEECCCCCEECHHHCEEECCCCCCCHHHHHCCCCCCCCHHHHHCCHHHCCCCCCE
IDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKPLRETIQKQMKEAYGLQTRPE
EECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
QIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVIIS
EEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEHHHHHCCCEEEEEECCCCCCHHH
ELRDLYHKHRVKMVFVNPTFQNPTGLVMSLERRKELVKICAHLQIPIVEDDPFSELAALD
HHHHHHHHCCEEEEEECCCCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
SQIPAPLKQLDTDNVLYIGSLSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQ
CCCCCCHHHCCCCCEEEEECHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHH
VLANSVLNTPGYKVHLQQLHHVLKQRRGDLIEAFEAILPNDVVFIKPKGGFHLWVKLPVE
HHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCEEEEEECCEE
IRSIRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKTEARRIAEIIKQILIEKKCEE
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
A
C
>Mature Secondary Structure
MWKLAGNSNLPIYLQIVDLIETKIINGELLPEEKLPPERQLAEMFGVNRSTVVRALDELT
CEEECCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
ARAVIIRKQGSGTTVNAEKWGLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERADSDQV
HEEEEEEECCCCCEECHHHCEEECCCCCCCHHHHHCCCCCCCCHHHHHCCHHHCCCCCCE
IDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKPLRETIQKQMKEAYGLQTRPE
EECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
QIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVIIS
EEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEHHHHHCCCEEEEEECCCCCCHHH
ELRDLYHKHRVKMVFVNPTFQNPTGLVMSLERRKELVKICAHLQIPIVEDDPFSELAALD
HHHHHHHHCCEEEEEECCCCCCCCHHEEEHHHHHHHHHHHHHCCCEEECCCCHHHHHHHH
SQIPAPLKQLDTDNVLYIGSLSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQ
CCCCCCHHHCCCCCEEEEECHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHH
VLANSVLNTPGYKVHLQQLHHVLKQRRGDLIEAFEAILPNDVVFIKPKGGFHLWVKLPVE
HHHHHHHCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCEEEEEECCEE
IRSIRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKTEARRIAEIIKQILIEKKCEE
EECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]