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The map label for this gene is mepA [H]

Identifier: 226224693

GI number: 226224693

Start: 2165648

End: 2166979

Strand: Reverse

Name: mepA [H]

Synonym: Lm4b_02108

Alternate gene names: 226224693

Gene position: 2166979-2165648 (Counterclockwise)

Preceding gene: 226224694

Following gene: 226224692

Centisome position: 74.4

GC content: 37.54

Gene sequence:

>1332_bases
ATGGCAAAAAATATGGAAATTTTAGAAACAGATTCAGTTAAAAAGATTTACTTTAGATATTTAATTCCTTCCTTAGTGGG
AATGTTGTTAATGTCTTTAAATATTGTGATTGATGGAATTTTTGTTGGGCATAAGCTCGGCGGAGTGGCGCTGGCTGGCA
TAAATATAGCGGTGCCTGTATTTACGATTTTTACAGCGATTTCTATTTGGATTGGGATTGGTGCTGCGACTCAGTTTTCC
TTTGCGATTGGGGAGAAAAATGTCGCGAAAGCTCAAACGATTTTCACCAATGCGATTCTAGCTGTTGTTTCAATCACTGT
TATTATTGGAATTATAGCGTTTATTTTTAAAGTACCATTAGCTTATTTTTTAGGTGCGAATGATGATACGATTGGTTATG
TGCTCGAGTATATGAATATCCTGCTCGTATTTGGATTTGCGCTTACACTAGAAAATATTTTAAGTATTTTTGTACGTAAC
GATGGCGATCCTAATTTATCGATGATTGCGCTTATTGTAACAGCAATCAGTAATGTTATTTTGAACTATTTATTCTTATT
TGTATTCGAATGGGGCGTTACGGGTTCTGCGCTTGCTACGATGATTGCAATCATTATCGGTGTACTCATTTTAATTACCC
ATTTCTTCAAAAAATCAAGTCGTTTAAAATTTGTCAAAGTGGACTGGAACAAAGCGTTTTTCAAGAAAACTTTAGCAATT
GGCTTACCGAGCTTTTTAGCGGAAGTTGGGGTGTCTGTATTTACGCTAGGTTATAATATTTCGATTGCGGCTATTGCTGG
GACTGCTGGTGTGGCGGCGTTCTCGGTACTCAATTATACGCACAGTGTGATTTTGATGCTGTTCCTTGGAATGGGGTCCG
CGATTCAACCACTTATTAGTTATTATCGGGGCGCGAAAGCTAGACAAAAAGAAATAGAAACGTTGAAAATTGCGATTATG
GTAGCGTTCAGCACTGGAGTAGGCTTTTTGCTCGTTGGTCTCTTCGGTTCCAACTTGCTCGTTTCGATGTTCGGGAACTT
TAGCCCGGAAATTAAAGATTTAGCAAGTAACGGTATCAAATTATTCTATACAGCTTATCTGTTCATGGGCTTCAACTTTG
TTATGATGACCTATTTCCAAACATCGGACAAGGTAAAAATGGCTACATGGATAACGATATCGCGTGAGATTATTTTCATG
GTCATCTTCCTATTAGTGTTGCCACCAATCATTGGTATCCCGGGCGTTTGGCTAGCAATTCCAATTTCAGAAATGATTGT
AGCAGCATCCATCATATTCTATATGAAGAAAAAACATATTCTATTTAAATAA

Upstream 100 bases:

>100_bases
GTACGTGAACGACCCAGAAAGAACGGAAAAGAAAATTACAGCTTTATGGCAAATTTTCTGGAGAGGAATTACGCTAAAAG
CTTTGAATTAGAGGTGTAGT

Downstream 100 bases:

>100_bases
AAATGAGACAAAGATAGATGATATCTTCGTCTTTTTAGGAAATTAATACTAAATATGGACTTGAAAAAGGTGGAAGTAAG
ATGAATTTTCCTTTTTAGAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAKNMEILETDSVKKIYFRYLIPSLVGMLLMSLNIVIDGIFVGHKLGGVALAGINIAVPVFTIFTAISIWIGIGAATQFS
FAIGEKNVAKAQTIFTNAILAVVSITVIIGIIAFIFKVPLAYFLGANDDTIGYVLEYMNILLVFGFALTLENILSIFVRN
DGDPNLSMIALIVTAISNVILNYLFLFVFEWGVTGSALATMIAIIIGVLILITHFFKKSSRLKFVKVDWNKAFFKKTLAI
GLPSFLAEVGVSVFTLGYNISIAAIAGTAGVAAFSVLNYTHSVILMLFLGMGSAIQPLISYYRGAKARQKEIETLKIAIM
VAFSTGVGFLLVGLFGSNLLVSMFGNFSPEIKDLASNGIKLFYTAYLFMGFNFVMMTYFQTSDKVKMATWITISREIIFM
VIFLLVLPPIIGIPGVWLAIPISEMIVAASIIFYMKKKHILFK

Sequences:

>Translated_443_residues
MAKNMEILETDSVKKIYFRYLIPSLVGMLLMSLNIVIDGIFVGHKLGGVALAGINIAVPVFTIFTAISIWIGIGAATQFS
FAIGEKNVAKAQTIFTNAILAVVSITVIIGIIAFIFKVPLAYFLGANDDTIGYVLEYMNILLVFGFALTLENILSIFVRN
DGDPNLSMIALIVTAISNVILNYLFLFVFEWGVTGSALATMIAIIIGVLILITHFFKKSSRLKFVKVDWNKAFFKKTLAI
GLPSFLAEVGVSVFTLGYNISIAAIAGTAGVAAFSVLNYTHSVILMLFLGMGSAIQPLISYYRGAKARQKEIETLKIAIM
VAFSTGVGFLLVGLFGSNLLVSMFGNFSPEIKDLASNGIKLFYTAYLFMGFNFVMMTYFQTSDKVKMATWITISREIIFM
VIFLLVLPPIIGIPGVWLAIPISEMIVAASIIFYMKKKHILFK
>Mature_442_residues
AKNMEILETDSVKKIYFRYLIPSLVGMLLMSLNIVIDGIFVGHKLGGVALAGINIAVPVFTIFTAISIWIGIGAATQFSF
AIGEKNVAKAQTIFTNAILAVVSITVIIGIIAFIFKVPLAYFLGANDDTIGYVLEYMNILLVFGFALTLENILSIFVRND
GDPNLSMIALIVTAISNVILNYLFLFVFEWGVTGSALATMIAIIIGVLILITHFFKKSSRLKFVKVDWNKAFFKKTLAIG
LPSFLAEVGVSVFTLGYNISIAAIAGTAGVAAFSVLNYTHSVILMLFLGMGSAIQPLISYYRGAKARQKEIETLKIAIMV
AFSTGVGFLLVGLFGSNLLVSMFGNFSPEIKDLASNGIKLFYTAYLFMGFNFVMMTYFQTSDKVKMATWITISREIIFMV
IFLLVLPPIIGIPGVWLAIPISEMIVAASIIFYMKKKHILFK

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48534; Mature: 48403

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNMEILETDSVKKIYFRYLIPSLVGMLLMSLNIVIDGIFVGHKLGGVALAGINIAVPV
CCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHH
FTIFTAISIWIGIGAATQFSFAIGEKNVAKAQTIFTNAILAVVSITVIIGIIAFIFKVPL
HHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYFLGANDDTIGYVLEYMNILLVFGFALTLENILSIFVRNDGDPNLSMIALIVTAISNVI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LNYLFLFVFEWGVTGSALATMIAIIIGVLILITHFFKKSSRLKFVKVDWNKAFFKKTLAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHH
GLPSFLAEVGVSVFTLGYNISIAAIAGTAGVAAFSVLNYTHSVILMLFLGMGSAIQPLIS
CCHHHHHHCCHHHEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YYRGAKARQKEIETLKIAIMVAFSTGVGFLLVGLFGSNLLVSMFGNFSPEIKDLASNGIK
HHCCCCHHHHHHHHHEEEEEEEEHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHH
LFYTAYLFMGFNFVMMTYFQTSDKVKMATWITISREIIFMVIFLLVLPPIIGIPGVWLAI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
PISEMIVAASIIFYMKKKHILFK
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKNMEILETDSVKKIYFRYLIPSLVGMLLMSLNIVIDGIFVGHKLGGVALAGINIAVPV
CCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHH
FTIFTAISIWIGIGAATQFSFAIGEKNVAKAQTIFTNAILAVVSITVIIGIIAFIFKVPL
HHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYFLGANDDTIGYVLEYMNILLVFGFALTLENILSIFVRNDGDPNLSMIALIVTAISNVI
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
LNYLFLFVFEWGVTGSALATMIAIIIGVLILITHFFKKSSRLKFVKVDWNKAFFKKTLAI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHH
GLPSFLAEVGVSVFTLGYNISIAAIAGTAGVAAFSVLNYTHSVILMLFLGMGSAIQPLIS
CCHHHHHHCCHHHEEECCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
YYRGAKARQKEIETLKIAIMVAFSTGVGFLLVGLFGSNLLVSMFGNFSPEIKDLASNGIK
HHCCCCHHHHHHHHHEEEEEEEEHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCHH
LFYTAYLFMGFNFVMMTYFQTSDKVKMATWITISREIIFMVIFLLVLPPIIGIPGVWLAI
HHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
PISEMIVAASIIFYMKKKHILFK
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA