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The map label for this gene is yesM [H]

Identifier: 226224608

GI number: 226224608

Start: 2073758

End: 2075497

Strand: Reverse

Name: yesM [H]

Synonym: Lm4b_02023

Alternate gene names: 226224608

Gene position: 2075497-2073758 (Counterclockwise)

Preceding gene: 226224609

Following gene: 226224607

Centisome position: 71.26

GC content: 37.13

Gene sequence:

>1740_bases
ATGAGCATGACACAAGAATTACCACGCAAGCGCGTTTTCAAAAGGATGTTGTTAATTTTTTCTTTAACAAGTCTTTTTAC
GGTGAGCTTGTTACTTTTTTTCATTTATAAGTACTATACTAATATTCAGCTAGATACCAATCTCCAAAGAGCGGAAACCA
TTGCGAATAAACAGCTCGATGCACTTACGGAGAAGCAAAAGGCATTAATTAGTTTAACGCAAGATATTTACCGTAATAGC
GATTTGATGCAGGATGTTCAAATCGCGATGACAAATGATTACGGTAGCTACACAGAGCAAAATATCGATAACTATTTTAA
AAGTAAAAATTTCTATTCTGTAGATATGCAAACGTATTTACAGTCTTATTTTTCGTATGATGAAGATATTATCGCGCTGC
AGCTCATTTCGGATGATGGGAGTTACTCTTATACATTTCCGAGCCGTTACCGTGAATGGAAAGAAACGGTTGATACATAC
GGGGAGGCAAATATCGCCACCGAAGCATCAAAGCAAGGGACTTTTTATACAATCGAAAATAAAATAGTTGTGAAACAGCC
GATTAATGATCCAAGCACATTAAAACAAATGGGTTATCTGCTTCTTTACATTGATCCGACTTTTCTAAGCAAATGGATTA
CGAAAGATTATCAAAACTCGATTTTTCAAATACAAAACACGAAGGGAGTCGAGTTATATTCCAACCACCCAAAGAAACAA
ATCCAAACGCCTGAAAAACAAGGATGGCTTCATGCTGACAACAAAAAAGTATACTTTCAAAAAACGGAAGATGAAACAAG
TGGCTTGAAAAACAATACGTTTTTATATCGAGTAACAGATGACAGCGCGCCGCTCATCGAACTTACTTTATTTGGTATTG
GGCTGTTATTAGTTATTTTTTCTATTAGCATTAATTTTGTTATTAGTAGGCGTTATTCTAAGCGGATTTTAACGATTATT
GGCGGGATGAACCGGGTGGAAATGGGGACCCTTGATGCAAAGCTTCCGGTCGATAATAACGGGGATGAGCTGACGATGAT
TAGTGAGCGGTTTAACCATATGACAGAAAACCTCGATGCTTATGTGAAGAAGGTCTATAGCCTAGAAATGGAAGAACAAA
AAGCGCGGCTCAAGGCACTCCAAGGTCAAATGCAACCTCATTTTCTTTATAATTCACTAGAAGCAATTAGGATGAACGCA
CGCGTAGAAGGAGCCAAAGCGACAAGTGATATGATTTATCAACTTGCAACACTACTGCGCTACACAGCTAATCACCGTGA
AATCACCACTTTAGGTGAAGAAATCAATTACGTGAAACAATATGTCCGCTTTATGGAAATGCGCCACGAACAGCCAATTA
AGCTGGAAATCAATATTGAAAAACGTTTCAATCATACGCAGATTCCACGGTTTGCTCTGCAGCCGCTTATTGAAAACTTT
TTCAAATATGCTTTTAAAGAAAATCAAAATCCAATAGTCGTAATTACGGTCACTGCAGAAAATGACAATTTACAATTTAG
AATTGAAGACAATGGTTCGGGAATCGATGCAGAGAAATTAAAAGAAGTGCAAGCAACAATTGAAAGTAAAGATGAGACGA
GCCACATCGGTCTAGCTAATTTAAACAAACGATTGCAGCTTTTATATGGAGAAAATTATCGATTAACAATCAAGAGTAAA
GCAAATGAAGGTACCATCATTCTGTTTCAAGTACCTCAAAATACGGGAGGAGAAAAGTAA

Upstream 100 bases:

>100_bases
TGAAAATCAATTTACACCGCTTCAAGCAAATGGAGCCTAAGTAACCCCTTACATTATTGGTGATAGTATGCAATAATCAG
AAAAGAAGAGGGGGCAGTGA

Downstream 100 bases:

>100_bases
TGCTAAAAATTGTACTAGTAGACGACGAGCCCCTTATTCTCAAAGGTTTAGAAAGTATTATTCCAGAATTTGAGCAATCA
ATTGAAATTGTTGGAACGGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MSMTQELPRKRVFKRMLLIFSLTSLFTVSLLLFFIYKYYTNIQLDTNLQRAETIANKQLDALTEKQKALISLTQDIYRNS
DLMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYLQSYFSYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTY
GEANIATEASKQGTFYTIENKIVVKQPINDPSTLKQMGYLLLYIDPTFLSKWITKDYQNSIFQIQNTKGVELYSNHPKKQ
IQTPEKQGWLHADNKKVYFQKTEDETSGLKNNTFLYRVTDDSAPLIELTLFGIGLLLVIFSISINFVISRRYSKRILTII
GGMNRVEMGTLDAKLPVDNNGDELTMISERFNHMTENLDAYVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNA
RVEGAKATSDMIYQLATLLRYTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEINIEKRFNHTQIPRFALQPLIENF
FKYAFKENQNPIVVITVTAENDNLQFRIEDNGSGIDAEKLKEVQATIESKDETSHIGLANLNKRLQLLYGENYRLTIKSK
ANEGTIILFQVPQNTGGEK

Sequences:

>Translated_579_residues
MSMTQELPRKRVFKRMLLIFSLTSLFTVSLLLFFIYKYYTNIQLDTNLQRAETIANKQLDALTEKQKALISLTQDIYRNS
DLMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYLQSYFSYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTY
GEANIATEASKQGTFYTIENKIVVKQPINDPSTLKQMGYLLLYIDPTFLSKWITKDYQNSIFQIQNTKGVELYSNHPKKQ
IQTPEKQGWLHADNKKVYFQKTEDETSGLKNNTFLYRVTDDSAPLIELTLFGIGLLLVIFSISINFVISRRYSKRILTII
GGMNRVEMGTLDAKLPVDNNGDELTMISERFNHMTENLDAYVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNA
RVEGAKATSDMIYQLATLLRYTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEINIEKRFNHTQIPRFALQPLIENF
FKYAFKENQNPIVVITVTAENDNLQFRIEDNGSGIDAEKLKEVQATIESKDETSHIGLANLNKRLQLLYGENYRLTIKSK
ANEGTIILFQVPQNTGGEK
>Mature_578_residues
SMTQELPRKRVFKRMLLIFSLTSLFTVSLLLFFIYKYYTNIQLDTNLQRAETIANKQLDALTEKQKALISLTQDIYRNSD
LMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYLQSYFSYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTYG
EANIATEASKQGTFYTIENKIVVKQPINDPSTLKQMGYLLLYIDPTFLSKWITKDYQNSIFQIQNTKGVELYSNHPKKQI
QTPEKQGWLHADNKKVYFQKTEDETSGLKNNTFLYRVTDDSAPLIELTLFGIGLLLVIFSISINFVISRRYSKRILTIIG
GMNRVEMGTLDAKLPVDNNGDELTMISERFNHMTENLDAYVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNAR
VEGAKATSDMIYQLATLLRYTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEINIEKRFNHTQIPRFALQPLIENFF
KYAFKENQNPIVVITVTAENDNLQFRIEDNGSGIDAEKLKEVQATIESKDETSHIGLANLNKRLQLLYGENYRLTIKSKA
NEGTIILFQVPQNTGGEK

Specific function: Member of the two-component regulatory system yesM/yesN. Probably activates yesN by phosphorylation [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=214, Percent_Identity=29.9065420560748, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788446, Length=216, Percent_Identity=26.8518518518519, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR010559
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67330; Mature: 67198

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMTQELPRKRVFKRMLLIFSLTSLFTVSLLLFFIYKYYTNIQLDTNLQRAETIANKQLD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHH
ALTEKQKALISLTQDIYRNSDLMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYL
HHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHHHH
QSYFSYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTYGEANIATEASKQGTFYTIEN
HHHHCCCCCEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
KIVVKQPINDPSTLKQMGYLLLYIDPTFLSKWITKDYQNSIFQIQNTKGVELYSNHPKKQ
EEEEECCCCCHHHHHHHCEEEEEECHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHH
IQTPEKQGWLHADNKKVYFQKTEDETSGLKNNTFLYRVTDDSAPLIELTLFGIGLLLVIF
CCCCCCCCCEECCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHH
SISINFVISRRYSKRILTIIGGMNRVEMGTLDAKLPVDNNGDELTMISERFNHMTENLDA
HHHHHHEEECHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCEEEHHHHHHHHHHHHHH
YVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNARVEGAKATSDMIYQLATLLR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECCEECCCCHHHHHHHHHHHHHH
YTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEINIEKRFNHTQIPRFALQPLIENF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHH
FKYAFKENQNPIVVITVTAENDNLQFRIEDNGSGIDAEKLKEVQATIESKDETSHIGLAN
HHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
LNKRLQLLYGENYRLTIKSKANEGTIILFQVPQNTGGEK
HCCEEEEEECCCEEEEEEECCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SMTQELPRKRVFKRMLLIFSLTSLFTVSLLLFFIYKYYTNIQLDTNLQRAETIANKQLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHH
ALTEKQKALISLTQDIYRNSDLMQDVQIAMTNDYGSYTEQNIDNYFKSKNFYSVDMQTYL
HHHHHHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHHHH
QSYFSYDEDIIALQLISDDGSYSYTFPSRYREWKETVDTYGEANIATEASKQGTFYTIEN
HHHHCCCCCEEEEEEEECCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEC
KIVVKQPINDPSTLKQMGYLLLYIDPTFLSKWITKDYQNSIFQIQNTKGVELYSNHPKKQ
EEEEECCCCCHHHHHHHCEEEEEECHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHH
IQTPEKQGWLHADNKKVYFQKTEDETSGLKNNTFLYRVTDDSAPLIELTLFGIGLLLVIF
CCCCCCCCCEECCCCEEEEEECCCHHCCCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHH
SISINFVISRRYSKRILTIIGGMNRVEMGTLDAKLPVDNNGDELTMISERFNHMTENLDA
HHHHHHEEECHHHHHHHHHHCCCCEEEECCCCEECCCCCCCCCEEEHHHHHHHHHHHHHH
YVKKVYSLEMEEQKARLKALQGQMQPHFLYNSLEAIRMNARVEGAKATSDMIYQLATLLR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEECCEECCCCHHHHHHHHHHHHHH
YTANHREITTLGEEINYVKQYVRFMEMRHEQPIKLEINIEKRFNHTQIPRFALQPLIENF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHH
FKYAFKENQNPIVVITVTAENDNLQFRIEDNGSGIDAEKLKEVQATIESKDETSHIGLAN
HHHHHHCCCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHH
LNKRLQLLYGENYRLTIKSKANEGTIILFQVPQNTGGEK
HCCEEEEEECCCEEEEEEECCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]