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The map label for this gene is algC [H]

Identifier: 226224475

GI number: 226224475

Start: 1932768

End: 1934279

Strand: Reverse

Name: algC [H]

Synonym: Lm4b_01888

Alternate gene names: 226224475

Gene position: 1934279-1932768 (Counterclockwise)

Preceding gene: 226224476

Following gene: 226224474

Centisome position: 66.41

GC content: 40.54

Gene sequence:

>1512_bases
ATGAATCAATCAGAAACGAAAGCGTTAGAAGCACTGCAAAACGGATCAGACATACGTGGAATAGCTATTGCTACGGAAAA
ATATCAGATTACGCTAACAGACGAACGTGTAGAAAAGATTGCTTATGGCTTTGCGAAATGGCTAAAAGAGGAGAAAAAAG
TGGAAGGTCAAGCGAAAGTGGCAATTGGCCATGATAGCAGACTTTCAGCTGAACGTTTAAAAGCGGCACTTGTCAAAGGG
TTAACTTTTGCAGGAATCAATGTGGTGGATGTAGGGCTTGCAACTACGCCGGCCATGTTTATGGCAACTCAGTACGAAGA
CTATAACTGCGATGCCGGCATTATGATTACAGCGAGCCACTTACCTTTTATGTATAATGGACTAAAATTATTTACGAAAT
CTGGTGGAGCTGAACACGAAGATATTGATTATATCGTGGCTCACGCAGATAAATCATTCATAGAAAATGGACTAAATCTT
GGGAAGGTAACAAAACAAGATTTACTTTCTACATATGCAGCAGACTTAACGGATAAAATTAGAGCTGGAATCACAGATGC
AGCTGACAAAATGAAGCCACTTCTAGGAAGCCATATTATTGTCGATGCAGGGAACGGCGCTGGCGGCTTTTTTGCTGAGA
AAGTATTGGCAGAACTTGGCGCAGACATTTCTGGAAGCCAGTTTTTAGATCCGGATGGAAATTTTCCTAATCATATTCCG
AACCCTGACAATGAGGAAGCTATGGCTAGTTTGAAAAAAGCGGTCCTTGCTAGTGGAGCGGATTTAGGCGTGATTTTTGA
TACGGATGTAGACCGTGCTGCGATTATGGATAAAAATGGCGAAAGTTTAAACCGCAACCCATTAATTGCTGTTATCTCTA
GTATTATTTTAGAAGAAAAACCAGGAACAACTATCGTGACTGACTCCACAACATCTGGGCATTTGCAAACCTTTATCGAA
GCAAAAGGCGGGAAACAACACCGATTTAAACGTGGTTATCGTAATGTTATCAATGAAGCACTGCGCCTAAATGCAGACGG
AACACCATCAGAAATTGCTATCGAAGTAAGTGGTCATGCCGCATTAAAAGAAAATTATTTCTTGGATGATGGCGCTTATC
TCATTGCCAAAATTTTAATGACTTATGCCACTTTACGAAAAAATGGAAAAGATTTGCCAGATTTAATAGCCGATTTAAGA
GAACCGGCTGAAAGCGAAGAAATTCGTTTGAGTATTACCGCAACCGATTTTAAAGCTTATGGAAAAGAAGTTCTAGCTGA
TTTTCTGACTTTCGTAGAAGCTGATCCGGATATGGAATTAGAACCTGTGAACCAAGAAGGAATTCGTGTGAATACGAAAG
GTGCGCTTGGTGAAGGCTGGTTCTTACTACGAATGAGCTTACATGAACCGGTAATGCCGATGAATTTAGAAAGTGATGAA
GCTGGCGGCATCCGAAAAGTGAAAAATCGTTTAGCAGGATTTTTCGCGAGTAAAGCAGAATTAAAGATGTAA

Upstream 100 bases:

>100_bases
TTATTATCGCGAATAGAGCACATCTTTTGTAAAAGCTATGTGAAAATTTCGCAATTTAAGCTATAATGAAGGGGAAAAAT
ACAGAAGCTGGAGGAATGAC

Downstream 100 bases:

>100_bases
ACTACAAAGCAGCTGATATATTTTGGCTGCTTTTTAATATGCTTTGAGTTCTAAATAATGCTAGCTGCATAGTACAGTAT
GATTGTGAATATGTTATTAT

Product: phosphoglucomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MNQSETKALEALQNGSDIRGIAIATEKYQITLTDERVEKIAYGFAKWLKEEKKVEGQAKVAIGHDSRLSAERLKAALVKG
LTFAGINVVDVGLATTPAMFMATQYEDYNCDAGIMITASHLPFMYNGLKLFTKSGGAEHEDIDYIVAHADKSFIENGLNL
GKVTKQDLLSTYAADLTDKIRAGITDAADKMKPLLGSHIIVDAGNGAGGFFAEKVLAELGADISGSQFLDPDGNFPNHIP
NPDNEEAMASLKKAVLASGADLGVIFDTDVDRAAIMDKNGESLNRNPLIAVISSIILEEKPGTTIVTDSTTSGHLQTFIE
AKGGKQHRFKRGYRNVINEALRLNADGTPSEIAIEVSGHAALKENYFLDDGAYLIAKILMTYATLRKNGKDLPDLIADLR
EPAESEEIRLSITATDFKAYGKEVLADFLTFVEADPDMELEPVNQEGIRVNTKGALGEGWFLLRMSLHEPVMPMNLESDE
AGGIRKVKNRLAGFFASKAELKM

Sequences:

>Translated_503_residues
MNQSETKALEALQNGSDIRGIAIATEKYQITLTDERVEKIAYGFAKWLKEEKKVEGQAKVAIGHDSRLSAERLKAALVKG
LTFAGINVVDVGLATTPAMFMATQYEDYNCDAGIMITASHLPFMYNGLKLFTKSGGAEHEDIDYIVAHADKSFIENGLNL
GKVTKQDLLSTYAADLTDKIRAGITDAADKMKPLLGSHIIVDAGNGAGGFFAEKVLAELGADISGSQFLDPDGNFPNHIP
NPDNEEAMASLKKAVLASGADLGVIFDTDVDRAAIMDKNGESLNRNPLIAVISSIILEEKPGTTIVTDSTTSGHLQTFIE
AKGGKQHRFKRGYRNVINEALRLNADGTPSEIAIEVSGHAALKENYFLDDGAYLIAKILMTYATLRKNGKDLPDLIADLR
EPAESEEIRLSITATDFKAYGKEVLADFLTFVEADPDMELEPVNQEGIRVNTKGALGEGWFLLRMSLHEPVMPMNLESDE
AGGIRKVKNRLAGFFASKAELKM
>Mature_503_residues
MNQSETKALEALQNGSDIRGIAIATEKYQITLTDERVEKIAYGFAKWLKEEKKVEGQAKVAIGHDSRLSAERLKAALVKG
LTFAGINVVDVGLATTPAMFMATQYEDYNCDAGIMITASHLPFMYNGLKLFTKSGGAEHEDIDYIVAHADKSFIENGLNL
GKVTKQDLLSTYAADLTDKIRAGITDAADKMKPLLGSHIIVDAGNGAGGFFAEKVLAELGADISGSQFLDPDGNFPNHIP
NPDNEEAMASLKKAVLASGADLGVIFDTDVDRAAIMDKNGESLNRNPLIAVISSIILEEKPGTTIVTDSTTSGHLQTFIE
AKGGKQHRFKRGYRNVINEALRLNADGTPSEIAIEVSGHAALKENYFLDDGAYLIAKILMTYATLRKNGKDLPDLIADLR
EPAESEEIRLSITATDFKAYGKEVLADFLTFVEADPDMELEPVNQEGIRVNTKGALGEGWFLLRMSLHEPVMPMNLESDE
AGGIRKVKNRLAGFFASKAELKM

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=478, Percent_Identity=29.0794979079498, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789566, Length=467, Percent_Identity=26.9807280513919, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54605; Mature: 54605

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSETKALEALQNGSDIRGIAIATEKYQITLTDERVEKIAYGFAKWLKEEKKVEGQAKV
CCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEE
AIGHDSRLSAERLKAALVKGLTFAGINVVDVGLATTPAMFMATQYEDYNCDAGIMITASH
EECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEEEECCCCCCCCCEEEEECC
LPFMYNGLKLFTKSGGAEHEDIDYIVAHADKSFIENGLNLGKVTKQDLLSTYAADLTDKI
CCHHHCCEEEEECCCCCCCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RAGITDAADKMKPLLGSHIIVDAGNGAGGFFAEKVLAELGADISGSQFLDPDGNFPNHIP
HCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
NPDNEEAMASLKKAVLASGADLGVIFDTDVDRAAIMDKNGESLNRNPLIAVISSIILEEK
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHEECCCCCCCCCCHHHHHHHHHHHCCC
PGTTIVTDSTTSGHLQTFIEAKGGKQHRFKRGYRNVINEALRLNADGTPSEIAIEVSGHA
CCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCE
ALKENYFLDDGAYLIAKILMTYATLRKNGKDLPDLIADLREPAESEEIRLSITATDFKAY
ECCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEECHHHHH
GKEVLADFLTFVEADPDMELEPVNQEGIRVNTKGALGEGWFLLRMSLHEPVMPMNLESDE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCC
AGGIRKVKNRLAGFFASKAELKM
CCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNQSETKALEALQNGSDIRGIAIATEKYQITLTDERVEKIAYGFAKWLKEEKKVEGQAKV
CCCHHHHHHHHHHCCCCCEEEEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEE
AIGHDSRLSAERLKAALVKGLTFAGINVVDVGLATTPAMFMATQYEDYNCDAGIMITASH
EECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHEEEECCCCCCCCCEEEEECC
LPFMYNGLKLFTKSGGAEHEDIDYIVAHADKSFIENGLNLGKVTKQDLLSTYAADLTDKI
CCHHHCCEEEEECCCCCCCCCCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
RAGITDAADKMKPLLGSHIIVDAGNGAGGFFAEKVLAELGADISGSQFLDPDGNFPNHIP
HCCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCC
NPDNEEAMASLKKAVLASGADLGVIFDTDVDRAAIMDKNGESLNRNPLIAVISSIILEEK
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHEECCCCCCCCCCHHHHHHHHHHHCCC
PGTTIVTDSTTSGHLQTFIEAKGGKQHRFKRGYRNVINEALRLNADGTPSEIAIEVSGHA
CCCEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCE
ALKENYFLDDGAYLIAKILMTYATLRKNGKDLPDLIADLREPAESEEIRLSITATDFKAY
ECCCCEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEEECHHHHH
GKEVLADFLTFVEADPDMELEPVNQEGIRVNTKGALGEGWFLLRMSLHEPVMPMNLESDE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCC
AGGIRKVKNRLAGFFASKAELKM
CCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]