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The map label for this gene is pyrP

Identifier: 226224442

GI number: 226224442

Start: 1902422

End: 1903708

Strand: Reverse

Name: pyrP

Synonym: Lm4b_01855

Alternate gene names: 226224442

Gene position: 1903708-1902422 (Counterclockwise)

Preceding gene: 226224443

Following gene: 226224441

Centisome position: 65.36

GC content: 42.81

Gene sequence:

>1287_bases
ATGGCAGAAACGACAGAAACAGTGACAAAACCAGTACTAGATATACACGAAAGACCAAGCTTCAATAAATGGATTATTCT
TAGCATCCAGCACCTTTTCACCATGTTTGGCTCTACTATCTTTGTGCCAAGTGTGACAGGGTTAAGTCCGGGAGTGGCGC
TTGTATCTAGCGGACTCGGGACACTTGCTTATCTAGGAATTACTCGCGGGAAAATCCCCGCATATCTAGGTTCTTCCTTT
ACCTTTATTGCACCAATTACTGCACTACTTGCAGCCAAATCTGGCGGAGGTCCGGGCGCAGTTATGGTCGGAACGTTCTC
CGTCGGTGTAGTATATGCGATTGTTTCTCTAATTGTTTACTACGCTGGTGTTGACTGGATTCAAAAGGTTTTACCACCAA
TTGTTGTTGGGCCAGTAATCATGGTTATCGGTTTGTCGCTTGCTCCAAGTGCAGCAGCGATGGCGATGGGAACAAACAAT
GGTAAATACAGTTTAGAAACTTTGGCAGTAGCAGTAATTACGCTCCTTGCAACCATAATCGCAATGATGTTTTTCAAAGG
ATTTATGGGCTTGATTCCAATTTTGTTCGGCTTCACAGTCGGTTACTTAACAAGTATGGCTTTTGGGATGGTAGATTACA
CGTTAATCAAAAATGCCTCTTTCTTCCAAATTCCAGATTTCAGCATTCCATTTGTAAATATCGACCCAGTAATTACCGTG
ACGGTCATTCTAAGTATGGCGCCACTTGCGTTTGTCACAATGGCGGAACATATGGGGCATCAATTACTACTTAATCGAAT
TACGAATAAAAACTTCTTTAAAGACCCAGGACTTCATCGTTCCTTACTTGCAGATGGTACGGCTTCGATTATCGCATCGT
TCATCGGCGGACCACCTGTAACGACTTACGGTGAAAACATTGGCGTTCTTGCAATTACAAAAGTATATAGCGTGTTTGTT
ATCGGAGGAGCGGCAGTTTTCGCAATCCTCTTCGGATTTATCGGTTACATCAATGCAGTTATCACCTCGGTTCCTACAGC
AGTTCTAGGCGGCATTTCCCTGTTACTCTTTGGGGTTATTGCAACGAGTGGACTTCGAATGATGATTGAAAATAAAATTG
ATTTAAGTGTTAATCGTAATATGATTATTGCTTCGGTTGTACTAGTAGTCGGAATTGGCGGCTTATTCATTAAAGCTGGA
ACGTTCGAGCTATCTGGTATGGCGCTCGCGGCAGTTATTGGGATTATCTTAAACTTAGTATTACCAGCCGAGCACAGATC
AGCATAA

Upstream 100 bases:

>100_bases
TGTGAGGCTGACAAAGAGTGATTAATTTCTATAGGGGATTATTCTATACTCTTTGTCGACACAGACAAGGGGTATTTTTT
ATGAAGAAAGAGGGAAGAAA

Downstream 100 bases:

>100_bases
CACATGACAAAAAAACCTCTGCAGACAAAAAATTTACAGAGGTTTTTCTATAAAATGAAGTAGAAAAGGTGGCGCTTTAA
ATGAAAAATTTGTTGTCAAT

Product: uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MAETTETVTKPVLDIHERPSFNKWIILSIQHLFTMFGSTIFVPSVTGLSPGVALVSSGLGTLAYLGITRGKIPAYLGSSF
TFIAPITALLAAKSGGGPGAVMVGTFSVGVVYAIVSLIVYYAGVDWIQKVLPPIVVGPVIMVIGLSLAPSAAAMAMGTNN
GKYSLETLAVAVITLLATIIAMMFFKGFMGLIPILFGFTVGYLTSMAFGMVDYTLIKNASFFQIPDFSIPFVNIDPVITV
TVILSMAPLAFVTMAEHMGHQLLLNRITNKNFFKDPGLHRSLLADGTASIIASFIGGPPVTTYGENIGVLAITKVYSVFV
IGGAAVFAILFGFIGYINAVITSVPTAVLGGISLLLFGVIATSGLRMMIENKIDLSVNRNMIIASVVLVVGIGGLFIKAG
TFELSGMALAAVIGIILNLVLPAEHRSA

Sequences:

>Translated_428_residues
MAETTETVTKPVLDIHERPSFNKWIILSIQHLFTMFGSTIFVPSVTGLSPGVALVSSGLGTLAYLGITRGKIPAYLGSSF
TFIAPITALLAAKSGGGPGAVMVGTFSVGVVYAIVSLIVYYAGVDWIQKVLPPIVVGPVIMVIGLSLAPSAAAMAMGTNN
GKYSLETLAVAVITLLATIIAMMFFKGFMGLIPILFGFTVGYLTSMAFGMVDYTLIKNASFFQIPDFSIPFVNIDPVITV
TVILSMAPLAFVTMAEHMGHQLLLNRITNKNFFKDPGLHRSLLADGTASIIASFIGGPPVTTYGENIGVLAITKVYSVFV
IGGAAVFAILFGFIGYINAVITSVPTAVLGGISLLLFGVIATSGLRMMIENKIDLSVNRNMIIASVVLVVGIGGLFIKAG
TFELSGMALAAVIGIILNLVLPAEHRSA
>Mature_427_residues
AETTETVTKPVLDIHERPSFNKWIILSIQHLFTMFGSTIFVPSVTGLSPGVALVSSGLGTLAYLGITRGKIPAYLGSSFT
FIAPITALLAAKSGGGPGAVMVGTFSVGVVYAIVSLIVYYAGVDWIQKVLPPIVVGPVIMVIGLSLAPSAAAMAMGTNNG
KYSLETLAVAVITLLATIIAMMFFKGFMGLIPILFGFTVGYLTSMAFGMVDYTLIKNASFFQIPDFSIPFVNIDPVITVT
VILSMAPLAFVTMAEHMGHQLLLNRITNKNFFKDPGLHRSLLADGTASIIASFIGGPPVTTYGENIGVLAITKVYSVFVI
GGAAVFAILFGFIGYINAVITSVPTAVLGGISLLLFGVIATSGLRMMIENKIDLSVNRNMIIASVVLVVGIGGLFIKAGT
FELSGMALAAVIGIILNLVLPAEHRSA

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=447, Percent_Identity=23.7136465324385, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI44680143, Length=451, Percent_Identity=23.5033259423503, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI44680148, Length=446, Percent_Identity=23.9910313901345, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI40316845, Length=446, Percent_Identity=23.9910313901345, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1788843, Length=415, Percent_Identity=44.0963855421687, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87081818, Length=422, Percent_Identity=36.0189573459716, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87082181, Length=404, Percent_Identity=26.7326732673267, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082178, Length=469, Percent_Identity=26.6524520255864, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790087, Length=450, Percent_Identity=23.1111111111111, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17542262, Length=182, Percent_Identity=29.1208791208791, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17541904, Length=179, Percent_Identity=25.6983240223464, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=443, Percent_Identity=22.5733634311512, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=184, Percent_Identity=25.5434782608696, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71993493, Length=184, Percent_Identity=25.5434782608696, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21356175, Length=449, Percent_Identity=23.162583518931, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44880; Mature: 44749

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETTETVTKPVLDIHERPSFNKWIILSIQHLFTMFGSTIFVPSVTGLSPGVALVSSGLG
CCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHCCHH
TLAYLGITRGKIPAYLGSSFTFIAPITALLAAKSGGGPGAVMVGTFSVGVVYAIVSLIVY
HHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
YAGVDWIQKVLPPIVVGPVIMVIGLSLAPSAAAMAMGTNNGKYSLETLAVAVITLLATII
HHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
AMMFFKGFMGLIPILFGFTVGYLTSMAFGMVDYTLIKNASFFQIPDFSIPFVNIDPVITV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEECCCHHHHH
TVILSMAPLAFVTMAEHMGHQLLLNRITNKNFFKDPGLHRSLLADGTASIIASFIGGPPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCC
TTYGENIGVLAITKVYSVFVIGGAAVFAILFGFIGYINAVITSVPTAVLGGISLLLFGVI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSGLRMMIENKIDLSVNRNMIIASVVLVVGIGGLFIKAGTFELSGMALAAVIGIILNLV
HHCCHHEECCCCCCEEECCCHHHHHHHHHHHCCHHEEEECCEEECHHHHHHHHHHHHHHH
LPAEHRSA
CCCCCCCC
>Mature Secondary Structure 
AETTETVTKPVLDIHERPSFNKWIILSIQHLFTMFGSTIFVPSVTGLSPGVALVSSGLG
CCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHCCHH
TLAYLGITRGKIPAYLGSSFTFIAPITALLAAKSGGGPGAVMVGTFSVGVVYAIVSLIVY
HHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
YAGVDWIQKVLPPIVVGPVIMVIGLSLAPSAAAMAMGTNNGKYSLETLAVAVITLLATII
HHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHH
AMMFFKGFMGLIPILFGFTVGYLTSMAFGMVDYTLIKNASFFQIPDFSIPFVNIDPVITV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEECCCHHHHH
TVILSMAPLAFVTMAEHMGHQLLLNRITNKNFFKDPGLHRSLLADGTASIIASFIGGPPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCCC
TTYGENIGVLAITKVYSVFVIGGAAVFAILFGFIGYINAVITSVPTAVLGGISLLLFGVI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATSGLRMMIENKIDLSVNRNMIIASVVLVVGIGGLFIKAGTFELSGMALAAVIGIILNLV
HHCCHHEECCCCCCEEECCCHHHHHHHHHHHCCHHEEEECCEEECHHHHHHHHHHHHHHH
LPAEHRSA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]