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The map label for this gene is purE

Identifier: 226224378

GI number: 226224378

Start: 1833908

End: 1834396

Strand: Reverse

Name: purE

Synonym: Lm4b_01789

Alternate gene names: 226224378

Gene position: 1834396-1833908 (Counterclockwise)

Preceding gene: 226224379

Following gene: 226224377

Centisome position: 62.98

GC content: 41.31

Gene sequence:

>489_bases
ATGCCTGCTGTAATTGGTGTCATTATGGGGAGTACCTCAGATTGGGATACAATGAAAAAAGCATGTGATGTATTAGATGA
ATTAGAAATAGCTTATGAGAAAAAAGTGGTTTCTGCTCATCGTACACCAGATTTAATGTTTCAATATGCAGAACAAGCGC
GGGAACGTGGTTTGAAAATTATTATTGCCGGTGCTGGGGGCGCGGCGCATTTGCCAGGTATGATTGCGGCAAAGACGACT
TTGCCTGTTATTGGTGTGCCAATTAAATCAAAAGCGTTGAATGGAATGGATTCGTTACTTTCTATTGTACAGATGCCTGG
AGGTGTTCCGGTAGCGACAGTTGCTATTGGAGAAAGTGGTGCTGTAAATGCTGGCCTTCTAGCGGCGCAAATTTTATCCA
TAACGGACGATGCAATTACTAACAGATTACAAAAAAGACGTGCTACACTAGAAGAAACAGTTCTAGAAAGTAGTGATTAT
CTTGGATAA

Upstream 100 bases:

>100_bases
AAAATGTAACAATTAAATGTTCGATTTTTCGTTGACATTTATCGTGCCTATTGTTAGAATGAAGGAGTCGAAAAGAGATT
ATTAAGGAGTTGATCACGTA

Downstream 100 bases:

>100_bases
AAAATTTTTACTGACAAATAGTACTATTGGTATTATTGGTGGCGGACAACTTGGACGTATGCTTGCTCTTGCGGCGAAAG
CGATGGGGTATCGTATTATT

Product: hosphoribosylaminoimidazole carboxylase I

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MPAVIGVIMGSTSDWDTMKKACDVLDELEIAYEKKVVSAHRTPDLMFQYAEQARERGLKIIIAGAGGAAHLPGMIAAKTT
LPVIGVPIKSKALNGMDSLLSIVQMPGGVPVATVAIGESGAVNAGLLAAQILSITDDAITNRLQKRRATLEETVLESSDY
LG

Sequences:

>Translated_162_residues
MPAVIGVIMGSTSDWDTMKKACDVLDELEIAYEKKVVSAHRTPDLMFQYAEQARERGLKIIIAGAGGAAHLPGMIAAKTT
LPVIGVPIKSKALNGMDSLLSIVQMPGGVPVATVAIGESGAVNAGLLAAQILSITDDAITNRLQKRRATLEETVLESSDY
LG
>Mature_161_residues
PAVIGVIMGSTSDWDTMKKACDVLDELEIAYEKKVVSAHRTPDLMFQYAEQARERGLKIIIAGAGGAAHLPGMIAAKTTL
PVIGVPIKSKALNGMDSLLSIVQMPGGVPVATVAIGESGAVNAGLLAAQILSITDDAITNRLQKRRATLEETVLESSDYL
G

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=161, Percent_Identity=56.5217391304348, Blast_Score=157, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=55.921052631579, Blast_Score=161, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17002; Mature: 16871

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAVIGVIMGSTSDWDTMKKACDVLDELEIAYEKKVVSAHRTPDLMFQYAEQARERGLKI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMIAAKTTLPVIGVPIKSKALNGMDSLLSIVQMPGGVPVATVAIGESG
EEECCCCCHHCCCHHHHHCCCCEECCCCHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
AVNAGLLAAQILSITDDAITNRLQKRRATLEETVLESSDYLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PAVIGVIMGSTSDWDTMKKACDVLDELEIAYEKKVVSAHRTPDLMFQYAEQARERGLKI
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMIAAKTTLPVIGVPIKSKALNGMDSLLSIVQMPGGVPVATVAIGESG
EEECCCCCHHCCCHHHHHCCCCEECCCCHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
AVNAGLLAAQILSITDDAITNRLQKRRATLEETVLESSDYLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]