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The map label for this gene is mutS2 [H]

Identifier: 226223832

GI number: 226223832

Start: 1237770

End: 1240127

Strand: Direct

Name: mutS2 [H]

Synonym: Lm4b_01237

Alternate gene names: 226223832

Gene position: 1237770-1240127 (Clockwise)

Preceding gene: 226223831

Following gene: 226223833

Centisome position: 42.5

GC content: 41.05

Gene sequence:

>2358_bases
ATGGAAAAAAAAGTAGAAGCCATTTTAGAATTTGATAAAATAAAAAAACAACTCACCGAATTTGCTTCTTCGTCACTGGG
GGAGCAAGCGATTTTGGAACTCGCTCCAGCAACTGATTTTCAAGTAGTTCAAAAAACGCAACTTGAAACAGAAGAAGGAG
CCAAGATTATTCGTTTACGGGGAAGTGCGCCAATTACTGGTCTAACAGATGTTTTTGCACATTTGAAACGTTTAGAGATT
GGTGGCGATTTAAACGGGCTAGAAATTTACCAAATAGGTAGTAACTTGCGCGTTAGCCGTCAAATGAAGAATTTTATGAA
CGATTTACTGGAAATCGGTGTCGAATTGCCTTTACTCGGCGCCCTTTCGGATGAACTTTTAGTACTAAAAGAAGTAGAAG
AGGATATTGCGATTTCAGTAGATGAAAGCGGGAAAGTGTTAGATACTGCGAGTGAAGCGCTTAGTACGATTCGCCGAACA
CTCCGCCGTACCGAAGACCGCGTACGTGAAAAACTAGAATCTTATTTGCGCGATCGTAATGCCTCTAAAATGTTAAGCGA
TGCGGTTATTACGATTCGAAATGATCGTTATGTTATCCCAGTTAAACAAGAATACAAAGGTCATTATGGTGGTATCGTTC
ATGACCAGTCTGCTTCCGGTCAAACGCTTTTCATCGAGCCACAAAGTGTAGTGGATTTAAACAACGAACGAAAAGCACTT
CAAGCAAAGGAAAAACAAGAAATAGAACGCATTCTTGCTGAAATTTCTGCTTCACTAGCTGCTTGGATTAATGAAATTCA
TCATAATACTTTCATCCTCGGGCGCTTTGATTTTATTTTCGCCAAAGCACGTTTCGGAAAAGCGATGAAAGCTGTAACAC
CGCATTTGAGTGATGCTGGTGTCGTCCATTTAATCGCCGCACGCCACCCGCTTTTAGACGCTGCGAAAGTTGTAGCGAAT
GATATTTATTTAGGCGAAGATTTCACTACCATCGTTATCACCGGTCCAAATACAGGTGGTAAAACAATTACCCTGAAAAC
ATTGGGATTACTAACACTCATGGCACAATCTGGACTTCAAATTCCCGCGCAAGAAGATTCTACTATCGCTGTTTTTGAGC
ATGTATTTGCCGATATTGGTGACGAACAATCCATCGAACAAAGTTTAAGTACGTTCTCATCTCACATGACGAATATTGTT
TCCATTTTGGGAAATGTTAATCAGAAATCGCTTATTTTGTACGATGAACTCGGAGCGGGAACAGACCCACAAGAAGGTGC
GGCTTTAGCAATCGCCATTCTTGATGCAAGCCATGCAAAAGGTGCAAGTGTTGTTGCGACGACCCATTATCCGGAACTAA
AAGCATATGGATATAATCGCGTTCACGCAACCAATGCATCTGTTGAGTTCAATGTCGAAACACTTAGCCCAACTTATAAA
TTATTAATCGGTGTACCCGGTCGAAGTAATGCTTTTGATATTTCACGCCGCTTAGGATTAAGCGAAAATATTATCACTGA
AGCAAGAAGCCTTGTCGATACCGAAAGTGCCGATTTAAATGATATGATTTCCAGCCTAGAAGAGAAACGGAACTTAGCGG
AAACCGAGTATGAGGAAGCACGTGAATTAGCTCGCGGGGCTGATAACCTTTTAAAAGATTTACAAAAAGAAATCAGCAAC
TACTATCAACAAAAAGATAAATTAATCGAACAAGCGAGTGAAAAAGCAGCAACTATTGTGGAAAAAGCCGAAGCCGAGGC
CGAAGAAATCATCCACGAATTGCGCACCATGCAATTAAACGGAGCAGCAGGAATCAAAGAACATGAACTTATCGATGCCA
AAACAAGACTTGGGAATGCTAAACCAAAAACAATAAACAAAACCATCCCACAAGCGCCAAAACAAAAACCACATGTATTC
CAAGAAGGCGACAATGTTCGTGTCCTCTCCCTTGGCCAAAAAGGCACACTTTTAAATAAAATTAGCGATAAAGAATGGAA
CGTCCAAATCGGCATCATCAAAATGAAAATCAAAACTACTGACTTAGAATACATTCAACCAGAAAAACCAAAAAAACAAC
GTATCATTACATCCGTTCATAGTAGTGGTTCTCCAGCTAAAAGCGAACTCGATTTACGCGGCGAACGATATGAAGACGCG
CTACAAAAAGTCGACAAATATCTAGATGAAGCACTACTCGCAGGATATCCTCAAGTTGCCATTATACACGGTAAAGGAAC
TGGTGCCCTTAGAACCGGGGTCACAGAATATCTGAAAAACCACCGCATGGTCAAATCAATCCGTTTCGGCGCAGCAGCAG
AAGGCGGAAATGGTGTAACGATTGTTGAGTTCAAGTAA

Upstream 100 bases:

>100_bases
AAAGCCTGGCTCGACAAATCGGCCATTCTAAATACGAAAACAGCAGCTGAATTTAAACATTTTTTACAGAATAAATAACT
TTTAAAAAGAAGGATGACTA

Downstream 100 bases:

>100_bases
ACAACTGAGCAAAAACATGGCTCCAAATAGGTCTAGGTGCTATACTGTGTGTACGAAAGTCATAAGGAGTGAATTAAATC
ATGGTAAAAGAAATTACAGA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLGALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAGVVHLIAARHPLLDAAKVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILGNVNQKSLILYDELGAGTDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADNLLKDLQKEISN
YYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVF
QEGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK

Sequences:

>Translated_785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLGALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAGVVHLIAARHPLLDAAKVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILGNVNQKSLILYDELGAGTDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADNLLKDLQKEISN
YYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVF
QEGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK
>Mature_785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLGALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAGVVHLIAARHPLLDAAKVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILGNVNQKSLILYDELGAGTDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADNLLKDLQKEISN
YYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVF
QEGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=262, Percent_Identity=31.6793893129771, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI284813531, Length=237, Percent_Identity=30.8016877637131, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI4557761, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4504191, Length=226, Percent_Identity=28.7610619469027, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI26638666, Length=174, Percent_Identity=35.0574712643678, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4505253, Length=174, Percent_Identity=35.0574712643678, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI26638664, Length=175, Percent_Identity=34.8571428571429, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI262231786, Length=175, Percent_Identity=34.8571428571429, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1789089, Length=330, Percent_Identity=26.969696969697, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534743, Length=280, Percent_Identity=25.3571428571429, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=361, Percent_Identity=24.0997229916898, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508447, Length=303, Percent_Identity=23.7623762376238, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539736, Length=172, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=386, Percent_Identity=28.2383419689119, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324482, Length=311, Percent_Identity=27.9742765273312, Blast_Score=107, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6321912, Length=323, Percent_Identity=23.8390092879257, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=246, Percent_Identity=28.0487804878049, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=150, Percent_Identity=31.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320047, Length=232, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664545, Length=278, Percent_Identity=26.6187050359712, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24584320, Length=244, Percent_Identity=27.0491803278689, Blast_Score=90, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86570; Mature: 86570

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCHHCCCEEEEEE
GSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLG
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
ALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRTLRRTEDRVREKLESYLRDRN
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
HHHHHHCCEEEEECCEEEEECHHHCCCCCCCEEECCCCCCCEEEECCHHHCCCCCHHHHH
QAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCC
VVHLIAARHPLLDAAKVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQ
CEEEEHHCCCHHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
IPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILGNVNQKSLILYDELGAG
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
TDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
CCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHCCCCEEEECCCEEEEEEEECCCCEE
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEA
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RELARGADNLLKDLQKEISNYYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVFQEGDNVRVLSLGQKGTLLNK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
ISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDA
CCCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHH
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVT
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEE
IVEFK
EEEEC
>Mature Secondary Structure
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATDFQVVQKTQLETEEGAKIIRLR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCHHCCCEEEEEE
GSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMNDLLEIGVELPLLG
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
ALSDELLVLKEVEEDIAISVDESGKVLDTASEALSTIRRTLRRTEDRVREKLESYLRDRN
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
HHHHHHCCEEEEECCEEEEECHHHCCCCCCCEEECCCCCCCEEEECCHHHCCCCCHHHHH
QAKEKQEIERILAEISASLAAWINEIHHNTFILGRFDFIFAKARFGKAMKAVTPHLSDAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCC
VVHLIAARHPLLDAAKVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQ
CEEEEHHCCCHHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
IPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILGNVNQKSLILYDELGAG
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
TDPQEGAALAIAILDASHAKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
CCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHCCCCEEEECCCEEEEEEEECCCCEE
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEA
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RELARGADNLLKDLQKEISNYYQQKDKLIEQASEKAATIVEKAEAEAEEIIHELRTMQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GAAGIKEHELIDAKTRLGNAKPKTINKTIPQAPKQKPHVFQEGDNVRVLSLGQKGTLLNK
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCHHHH
ISDKEWNVQIGIIKMKIKTTDLEYIQPEKPKKQRIITSVHSSGSPAKSELDLRGERYEDA
CCCCCCEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHH
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVT
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEE
IVEFK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]